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ORIGINAL RESEARCH article

Front. Surg.
Sec. Neurosurgery
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1409298
This article is part of the Research Topic Rising Stars in Neurosurgery 2024 View all articles

The nomogram for predicting nasal bleeding after endoscopic transsphenoidal resection of pituitary adenomas: A retrospective study

Provisionally accepted
Ying Wang Ying Wang 1,2Wei Wang Wei Wang 1,2Qinghua Huang Qinghua Huang 1,2Wei Yan Wei Yan 2Meijuan Lan Meijuan Lan 1*
  • 1 Nursing Department, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China, Hangzhou, China
  • 2 Neurosurgery Department, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China, Hangzhou, China

The final, formatted version of the article will be published soon.

    Objective: This study aimed to develop and validate a dynamic nomogram to assess the risk of nasal bleeding after endoscopic transnasal transsphenoidal pituitary tumor resection.: A retrospective analysis was conducted on patients who underwent endoscopic transnasal transsphenoidal pituitary tumor resection from June 2019 to June 2021. Univariate and multivariate logistic regression analyses were used to screen for independent risk factors for nasal bleeding from the training set. A multivariate logistic regression model was established, a nomogram was plotted, and it was validated in an internal validation set. The performance of the nomogram was evaluated based on the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). Results: The nomogram indicators included anticoagulant use, sphenoid sinus artery injury, nasal irrigation, platelet count (PLT), and constipation. The predictive model had an area under the ROC curve of 0.932 (95%CI: 0.873 -0.990) and 0.969 (95%CI: 0.940-0.997) for the training and validation sets, respectively, indicating good discrimination. The calibration curve showed good consistency between the actual and predicted incidence of nasal bleeding (p>0.05). DCA indicated that the nomogram had good clinical net benefit in predicting postoperative nasal bleeding in patients. Conclusion: In summary, this study explored the incidence and influencing factors of nasal bleeding after endoscopic transnasal transsphenoidal pituitary tumor resection and established a predictive model to assist clinical decision-making.

    Keywords: Ying Wang: conceptualization, methodology. Wei Wang: data curation and writing.Qinghua Huang: data curation and writing. Wei Yan: visualization and writing-reviewing. Meijuan Lan: conceptualization and supervision neuro-oncology, pituitary adenomas, endoscopic transsphenoidal resectionin, Nasal bleeding, nomogram

    Received: 29 Mar 2024; Accepted: 18 Jun 2024.

    Copyright: © 2024 Wang, Wang, Huang, Yan and Lan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Meijuan Lan, Nursing Department, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.