AUTHOR=Aldajani Ahmad , Alroqi Ahmad , Alramyan Rana , Alhejin Nujud , Alswayyed Mohammed , Alrajban Waleed A. , Alromaih Saud , Aloulah Mohammad O. , Alrasheed Abdulaziz S. , Aldousary Surayie , Alsaleh Saad 

TITLE=Prevalence of type 2 inflammation in patients with chronic rhinosinusitis with nasal polyps in Saudi Arabia

JOURNAL=Frontiers in Surgery

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2024.1421140

DOI=10.3389/fsurg.2024.1421140

ISSN=2296-875X

ABSTRACT=Background: Chronic Rhinosinusitis (CRS) is a common condition causing a significant worldwide burden, affecting 5-12% of the general population. CRS is classified into type 2 and non-type 2 disease based on endotype dominance. Type 2 inflammation is distinguished by the presence of IL-4, IL-5, and IL-13 cytokines, along with eosinophil and mast cell activation and recruitment. Evidence of type 2 inflammation is ascertained by tissue eosinophil count >10/high-power field (HPF) or serum eosinophil >250 cells/mcL or total immunoglobulin E (IgE) >100 IU/mL.