AUTHOR=Liu Quanrui TITLE=Case Report: Beware of arteria lusoria: a potential risk factor in esophagectomy surgery JOURNAL=Frontiers in Surgery VOLUME=Volume 12 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2025.1548041 DOI=10.3389/fsurg.2025.1548041 ISSN=2296-875X ABSTRACT=The aberrant right subclavian artery (ARSA), also known as lusoria artery, is a relatively rare vascular malformation influencing 0.6% to 1.4% of the population, and this figure elevates exponentially to 26%–34% among Down-syndrome individuals. However, few cases are available on esophageal cancer associated with ARSA. Here, we report a 30-year-old male esophageal cancer patient with arteria lusoria, which elevated surgical risks in esophagectomy. We reviewed the key points of anatomy and further complications to understand this vascular anomaly in esophagectomy. This report aims to raise awareness among thoracic surgeons and radiologists about the importance of thorough preoperative assessment and the unique challenges posed by ARSA in esophageal cancer surgery.