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        <title>Frontiers in Surgery | Neurosurgery section | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/surgery/sections/neurosurgery</link>
        <description>RSS Feed for Neurosurgery section in the Frontiers in Surgery journal | New and Recent Articles</description>
        <language>en-us</language>
        <generator>Frontiers Feed Generator,version:1</generator>
        <pubDate>2026-05-13T11:29:37.02+00:00</pubDate>
        <ttl>60</ttl>
        <item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1759497</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1759497</link>
        <title><![CDATA[Endoscopic-Assisted evacuation vs. burr-hole drainage for chronic subdural hematoma: a retrospective comparative study]]></title>
        <pubdate>2026-05-12T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Yang Mi</author><author>Chunhong Wang</author><author>Xiaohui Yao</author><author>Chunlei Ju</author><author>Kai Yang</author><author>Xulei Hu</author><author>Hao Li</author><author>Haiyang Su</author><author>Hongming Ji</author>
        <description><![CDATA[ObjectiveThis study aimed to compare the perioperative outcomes of endoscopic-assisted evacuation vs. burr-hole drainage methods in the chronic subdural hematoma (CSDH).MethodsThis retrospective cohort study included consecutive surgical cases of CSDH treated at Shanxi Provincial People's Hospital. After eligibility screening, 40 patients who underwent endoscopic-assisted evacuation and 158 who underwent burr-hole drainage were included in the analysis. Postoperative outcomes were systematically evaluated across intraoperative parameters, clinical and laboratory measures, procedural costs, and length of hospital stay.ResultsPatients who underwent endoscopic-assisted evacuation had significantly lower residual hematoma rates compared to those who underwent burr-hole drainage (35.00% vs. 54.78%, p = 0.0255). In the multiple regression analysis, the endoscopic group demonstrated improved neurological outcomes compared to the burr-hole group, with an odds ratio of 0.30 (95% CI: 0.12–0.63; p = 0.0021) for achieving a good functional outcome (lower mRS). However, endoscopic-assisted evacuation was associated with longer operative time, averaging 40.12 min longer (p < 0.0001) and higher hospitalization costs, averaging ¥9,600 more (p < 0.0001). Occurrence of postoperative complications such as intracranial pneumocephalus and hematoma recurrence were not significantly different between the two groups. Hemoglobin count was lower in the endoscopy group than in the burr-hole group (127.90 ± 14.93 vs. 133.00 ± 14.35 g/L, p = 0.0514) although no anemia-related complications occurred in the endoscopic group.ConclusionEndoscope-assisted evacuation enables more thorough clearance of hematoma and leads to better recovery for patients, without increasing procedural trauma or postoperative complications, though its higher cost may limit accessibility. These findings may help inform surgical decision-making and resource allocation.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1817241</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1817241</link>
        <title><![CDATA[Combined presigmoid retrolabyrinthine and retrosigmoid approach for large vestibular schwannoma: a case report]]></title>
        <pubdate>2026-05-11T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Mitsuru Kojima</author><author>Ryota Tamura</author><author>Konosuke Ishikawa</author><author>Taichi Sayanagi</author><author>Kosuke Karatsu</author><author>Ryo Ueda</author><author>Masahiro Toda</author>
        <description><![CDATA[BackgroundThe retrosigmoid approach is widely used for vestibular schwannoma resection. If the tumor is large, significant cerebellar retraction may be required, which can cause cerebellar edema. The presigmoid retrolabyrinthine route preserves the labyrinth and reduces cerebellar retraction and manipulation but provides only a narrow surgical corridor. We report the use of a combined approach to safely resect a large vestibular schwannoma with brainstem compression while avoiding complete postoperative deafness.MethodsA 24-year-old man presented with a large right vestibular schwannoma causing considerable brainstem compression. A combined temporal–suboccipital craniotomy with near-total mastoidectomy was performed to expose the sigmoid sinus while preserving the labyrinth. Microsurgical dissection was performed via the retrosigmoid corridor, while a rigid endoscope inserted through the presigmoid route provided direct visualization of the brainstem side.ResultsThis dual-corridor, dual-visualization technique enabled safe subperineural tumor removal and identification of the facial nerve. Gross total resection was achieved, and the postoperative course was uneventful. At approximately 6 months postoperatively, facial nerve function remained normal (House–Brackmann grade I). Formal postoperative pure-tone audiometry demonstrated residual hearing on the operated side, predominantly in the low-frequency range. Although serviceable hearing was not preserved, complete postoperative deafness was avoided.ConclusionIn large vestibular schwannomas with vertical brainstem extension, retrosigmoid resection alone may require excessive cerebellar retraction. Adding a presigmoid retrolabyrinthine corridor improves brainstem access, minimizes cerebellar retraction and manipulation, and facilitates safe tumor removal. This combined approach is a practical strategy for patients with significant brainstem compression.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1832695</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1832695</link>
        <title><![CDATA[Comparison of feasibility and efficacy of microsurgery and interventional techniques in the management of unruptured middle cerebral artery aneurysms with a history of transient ischemic attack]]></title>
        <pubdate>2026-05-11T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Te Li</author><author>Zhong Lin Li</author><author>Yin Ren</author><author>Manyi Xie</author>
        <description><![CDATA[ObjectiveTo compare the feasibility and efficacy of microsurgery and interventional techniques in the treatment of unruptured middle cerebral artery aneurysms (MCAA) with a history of transient ischemic attack (TIA).MethodsA prospective cohort comparative study was conducted using 100 patients with unruptured MCAA and a history of TIA who were admitted to our hospital from January 2023 to October 2024. The patients were divided into an interventional group and a microsurgical group, with 50 patients in each group. The interventional group underwent endovascular embolization, while the microsurgical group received microsurgical treatment. Various surgical outcomes were compared between the two groups, including procedure time, blood loss, postoperative hospital stay, and treatment costs. Rates of complete and incomplete aneurysm occlusion, treatment-related serious adverse events within 30 days after surgery, functional outcomes at 6 months after surgery as measured by the modified Rankin Scale (mRS), levels of miR-27a and miR-143, and recurrence rates at 1 year after surgery were also analyzed. Additionally, the cure rates for aneurysms in terms of shape and location were compared between the two groups.ResultsIn the interventional group, the operation time, blood loss, and postoperative hospital stay were lower than those in the microsurgical group. However, the treatment cost was higher in the interventional group (P < 0.05). The complete occlusion rate in the interventional group was 88.00%, which was lower than 100.00% in the microsurgical group (P < 0.05). The incidence of treatment-related SAEs within 30 days after surgery was 4.00% in the interventional group, compared to 16.00% in the microsurgical group (P < 0.05). At 6 months postoperatively, the rate of good functional outcomes was 92.00% in the interventional group, similar to 98.00% in the microsurgical group, with no statistically significant difference between the two groups (P > 0.05). Compared to preoperative levels, both groups showed significantly increased miR-27a and miR-143 levels at 3 days postoperatively (P < 0.05). However, the levels of miR-27a and miR-143 were lower in the interventional group at 3 days postoperatively than in the microsurgical group (P < 0.05). The recurrence rate at 1 year was 12.00% in the interventional group, compared to 0% in the microsurgical group (P < 0.05). For aneurysms with complex anatomies (wide neck, apex-neck ratio < 1.5, involvement of branches, or irregular shape), the complete occlusion rate after interventional treatment was significantly lower, and the 1-year recurrence rate was significantly higher (P < 0.05).ConclusionBoth microsurgery and interventional techniques are feasible therapeutic strategies for patients with unruptured MCAA and a history of TIA. Interventional techniques have the advantages of shorter operation time, less blood loss, faster postoperative recovery and higher perioperative safety, whereas microsurgery yields a higher complete occlusion rate and lower recurrence risk.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1717024</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1717024</link>
        <title><![CDATA[Case Report: Beyond two years: a neurosurgical review of prolonged survival and late recurrence in IDH-wildtype GBM]]></title>
        <pubdate>2026-05-11T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Hasan Ali Aydın</author><author>Emrah Keskin</author><author>Murat Kalaycı</author>
        <description><![CDATA[IDH-wildtype glioblastoma multiforme (GBM), the most lethal primary brain tumor in adults, has a median survival of 12–15 months despite maximal multimodal therapy, including resection, radiotherapy, and chemotherapy. However, a rare subset of patients, ranging from 1% to 5%, exhibits a prognosis that defies this expectation, demonstrating prolonged survival beyond two years or late recurrence after a recurrence-free interval exceeding two years. These exceptional outcomes are shaped by tumor biology and the extent of surgical resection, underscoring the pivotal role of neurosurgery in altering GBM's relentless course. This review synthesizes current evidence on the neurosurgical strategies driving such rare successes, illuminated by a striking case of a 67-year-old female who survived 42 months with methylated O6-methylguanine-DNA methyltransferase (MGMT) and telomerase reverse transcriptase (TERT) mutation positivity following gross total resection (GTR) without neuronavigation. Enhanced by intraoperative photographs and serial MRIs, we explore the technical nuances of resection, the impact of vascular complications such as an MCA infarct, and the diagnostic challenges posed by late recurrence, including pseudoprogression. By integrating insights from literature with clinical realities, this work advocates for refined surgical approaches, including optimized resection techniques and intraoperative imaging, to improve outcomes in IDH-wildtype GBM. This approach offers neurosurgeons actionable perspectives to confront this formidable disease.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1845552</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1845552</link>
        <title><![CDATA[Case Report: “Damage control” in obstetric neurosurgery: staged management of ruptured arteriovenous malformation with herniation]]></title>
        <pubdate>2026-05-08T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Qunlong Jiang</author><author>Xiaoli Liu</author><author>Zhiwei Zhang</author><author>Xiaokui Kang</author>
        <description><![CDATA[AimCatastrophic arteriovenous malformation (AVM) rupture during the second trimester presents a formidable clinical dilemma, necessitating a delicate balance between maternal resuscitation and fetal preservation. This challenge is acute when uncal herniation precludes extensive diagnostic workup.Material and methodsWe report a staged “damage control” strategy in a 27-year-old gravida (26 weeks) who presented with acute neurologic collapse, anisocoria, and coma. In advance of definitive angiographic characterization, we proceeded directly to emergency decompressive craniectomy to reverse impending herniation. Postpartum angiography revealed a small, eloquent Spetzler–Martin Grade II AVM. Definitive embolization (Onyx-18) was deferred until two months postpartum to ensure hemodynamic stability.ResultsThe emergency decompression successfully stabilized the patient. Following 12 weeks of supportive care, the pregnancy culminated in a successful term delivery. The patient achieved a full neurological recovery (modified Rankin Scale (mRS) score of 0), and the infant remained healthy.ConclusionThis case substantiates that in the context of pregnancy complicated by herniation, neurosurgical intervention must decouple acute decompression from vascular treatment. A staged approach may facilitate maternal neurological recovery while preserving fetal viability.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1816506</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1816506</link>
        <title><![CDATA[Targeting transthyretin deposition in lumbar spinal stenosis: a mechanistic rationale for tafamidis]]></title>
        <pubdate>2026-05-07T00:00:00Z</pubdate>
        <category>Opinion</category>
        <author>Iván Z. González</author><author>Giovanni Ureña</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1737542</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1737542</link>
        <title><![CDATA[Clinical importance of the persistent primitive hypoglossal artery in vascular lesions and endovascular treatment: a narrative review]]></title>
        <pubdate>2026-05-07T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Wei Li</author><author>Jinlu Yu</author>
        <description><![CDATA[The persistent primitive hypoglossal artery (PPHA) is a rare and anatomically complex cerebrovascular variant. Although typically asymptomatic, its presence is associated with various cerebrovascular pathologies, including intracranial aneurysms, carotid artery stenosis, acute large vessel occlusion, moyamoya disease, brain arteriovenous malformations, and other vascular anomalies. When such lesions involve the PPHA, therapeutic intervention may be necessitated. Surgical management is particularly challenging due to the artery's deep anatomical location and intricate surrounding vasculature. Consequently, endovascular therapy (EVT) has emerged as a preferable alternative to open surgery, offering a favorable safety profile and reduced technical complexity. Despite this, a substantial need remains in the literature regarding systematic evaluations of the PPHA's clinical significance in vascular pathology and the efficacy of EVT. This review aims to address this need through a comprehensive narrative synthesis of available literature and clinical experience in managing these complex cases. This review found that when EVT is required, the PPHA can serve as an access route. However, given that it often provides the sole blood supply to the posterior circulation—particularly in the context of bilateral hypoplastic vertebral arteries—the vessel must be meticulously preserved during interventions for associated conditions.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1720182</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1720182</link>
        <title><![CDATA[Bilateral approach selection in neuroendoscopic surgery for pituitary adenomas and health economic evaluation]]></title>
        <pubdate>2026-04-29T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Mingjian Li</author><author>Jiahui Liu</author><author>Lianshu Ding</author><author>Jing Xu</author><author>Yanxia Deng</author><author>Pengcheng Wang</author>
        <description><![CDATA[ObjectiveTo investigate the impact of bilateral approach selection in neuroendoscopic transsphenoidal surgery for pituitary adenomas on patient prognosis and to analyze the medical burden on patients from a health economic perspective.MethodsA retrospective analysis was conducted on the data of 197 patients who underwent pituitary adenoma surgery. The patients were divided into two groups based on the surgical approach: the transseptal approach group (n = 108) and the bilateral nostril expanded transsphenoidal approach group (n = 89). The medical burden, clinical efficacy, surgical indicators, hormone levels, and complications were compared between the two groups.ResultsCompared with the bilateral nostril expanded transsphenoidal approach, the transseptal approach was associated with significantly less intraoperative blood loss and shorter operative time (P < 0.05). No significant differences were observed in total medical costs, psychological burden, hormone profiles, or complication rates. Postoperative nasal packing was associated with reduced rates of diabetes insipidus and thyroid-stimulating hormone abnormalities (P < 0.05) and a marginally significant reduction in cerebrospinal fluid rhinorrhea (P = 0.05).ConclusionThe transseptal approach in pituitary adenoma surgery has the advantages of less intraoperative bleeding and shorter surgical duration, which can reduce postoperative anxiety and depression in patients. Postoperative nasal packing may reduce complications, but larger multicenter studies are warranted. Pituitary adenoma patients bear substantial economic and psychological burdens; multidisciplinary collaboration and pharmacoeconomic optimization are needed to reduce overall costs and improve outcomes.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1767159</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1767159</link>
        <title><![CDATA[A case report and reconsideration of pathogenesis: C5 palsy after corrective surgery for severe congenital cervicothoracic scoliosis]]></title>
        <pubdate>2026-04-22T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Bo Zhou</author><author>Qihui Duan</author><author>Wenjin Li</author><author>Li Zhang</author><author>Tao Li</author><author>Zhi Zhao</author><author>Yingsong Wang</author>
        <description><![CDATA[ObjectiveThis case report presents a rare case of C5 nerve root palsy following corrective surgery for severe congenital cervicothoracic scoliosis in a child, and explores its distinctive pathogenesis and treatment strategy.MethodsThis study was approved by the Medical Ethics Committee of the Second Affiliated Hospital of Kunming Medical University (PJ-2021-100), and informed consent was obtained from the patient's guardian. The clinical data of a 9-year-old boy with congenital cervicothoracic scoliosis (Cobb angle of 99°) who underwent posterior corrective instrumentation and fusion were retrospectively analyzed. Typical C5 palsy developed on postoperative day 7. Imaging studies and the clinical course were used to identify the responsible mechanism.ResultsPostoperatively, left deltoid strength decreased to grade II/III. CT excluded direct implant impingement, and no laminectomy had been performed, thus excluding the classic “posterior cord drift” hypothesis. Comparative imaging revealed a significant reduction in the vertical diameter of the C4–C5 foramen. We concluded that reduction maneuvers had transmitted excessive traction through the C5 pedicle screw, producing dynamic foraminal stenosis and nerve root stretching. Conservative management (with cervical traction and hyperbaric oxygen) was instituted, and complete neurological recovery was documented at 3 months.ConclusionIn cervical deformity surgeries performed without decompression, iatrogenic alteration of the foramina’s geometry, produced by corrective forces, is an important and frequently overlooked mechanism of postoperative C5 palsy. Surgeons should avoid overtightening a single screw during rod reduction; once the complication occurs, systematic conservative treatment usually yields a favorable outcome.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1759994</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1759994</link>
        <title><![CDATA[Adult intracranial pial arteriovenous fistulas: a case report and literature review]]></title>
        <pubdate>2026-04-20T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Hong Chen</author><author>Ying Xu</author><author>Zhongyue Liu</author><author>Yugang Jiang</author><author>Ming Wang</author>
        <description><![CDATA[Intracranial pial arteriovenous fistula (PAVF) is a rare high-flow cerebrovascular lesion defined by a direct shunt between pial/cortical arteries and a single draining vein or venous pouch without a nidus, adult cases are particularly uncommon. A 56-year-old woman presented with sudden severe headache after yoga. CT/MRI revealed a right frontal intracerebral hemorrhage associated with a giant venous pouch, and angiography demonstrated a single-channel PAVF fed by an MCA M2 branch with venous drainage to the superior sagittal and sphenoparietal sinuses. The patient underwent craniotomy for hematoma evacuation, microsurgical fistula disconnection, and venous pouch resection under indocyanine green angiography and FLOW800 guidance. Postoperative CT confirmed complete hematoma removal, and follow-up DSA on day 4 showed total obliteration of the fistula with no residual abnormal drainage. Pathology revealed a vascular malformation with focal calcification. She was discharged neurologically intact and remained symptom-free without recurrence on CTA at 3 months. Adult PAVF is extremely rare but carries a high risk of hemorrhage; early angiographic diagnosis and definitive flow disconnection yield excellent outcomes.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1800991</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1800991</link>
        <title><![CDATA[Outcome evaluation of the zero-profile device comprising two integrated variable angle screws used for single-level cervical degenerative disc disease: comparison with the plate-cage construct]]></title>
        <pubdate>2026-04-15T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Can Cao</author><author>Yun-Sheng Wang</author><author>You-bin Yang</author><author>Xian-Da Gao</author><author>Xing-Zhu Xu</author><author>Qing-Tao Liu</author><author>Lin-Feng Wang</author>
        <description><![CDATA[BackgroundZero-P VA device is a unique zero-profile device comprising only two integrated variable-angle screws which may provide inferior mechanical stability compared with other types of devices. There is a lack of comprehensive clinical and radiological evidence comparing the plate-cage construct (PCC) and the Zero-P VA device in single-level anterior cervical discectomy and fusion (ACDF).MethodsWe retrospectively reviewed consecutive patients who underwent single-level ACDF using either the Zero-P VA device (50 cases) or the PCC (51 cases). Clinical outcomes were evaluated using the Visual Analogue Scale (VAS) and Japanese Orthopaedic Association (JOA) scores. Radiological outcomes were assessed using standard lateral cervical x-ray films. Data were recorded preoperatively, immediately postoperatively, and at 3- and 12-month follow-up visits.ResultsVAS and JOA scores, cervical alignment, segmental angle, and surgical segment height were all significantly improved postoperatively in both groups. However, in the Zero-P VA group, the segmental angle and anterior height of the surgical segment at 3 and 12 months decreased significantly compared with immediate postoperative values and were significantly lower than those observed in the PCC group. The rate of segmental kyphosis was significantly higher in the Zero-P VA group at the 12-month follow-up (12% vs. 0%, p < 0.05), while fusion rates were comparable.ConclusionThe Zero-P VA device provides short-term clinical outcomes comparable to those of the PCC for single-level ACDF. However, it is associated with inferior radiological outcomes, specifically greater loss of segmental lordosis and anterior surgical segment height. The surgeon's choice of implant therefore involves a clinical trade-off between the established surgical advantages of a zero-profile system and the superior radiological stability offered by the PCC.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1726314</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1726314</link>
        <title><![CDATA[A refined radiological classification of anterior clinoid process pneumatization]]></title>
        <pubdate>2026-04-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Wilairat Kankuan Kaewborisutsakul</author><author>Anukoon Kaewborisutsakul</author><author>Chin Taweesomboonyat</author><author>Nuttha Sanghan</author>
        <description><![CDATA[IntroductionThe anterior clinoid process (ACP) is a critical anatomical landmark during skull base surgery. However, ACP pneumatization poses several risks during anterior clinoidectomy, including cerebrospinal fluid (CSF) leakage and optic nerve injury. Existing classification systems inadequately address clinically significant variations such as those involving the optic strut or planum sphenoidale. Therefore, this study aimed to determine the prevalence and morphological patterns of ACP pneumatization in a Thai population and propose a refined radiological classification system based on the route and extent of pneumatization.MethodsA retrospective computed tomography (CT)-based study was conducted on 400 ACPs from 200 patients aged ≥10 years. Pneumatization patterns were categorized into eight subtypes based on the pneumatization route (optic strut, planum sphenoidale, or both) and the degree of ACP involvement (≤50% or >50%). ACP morphometric data and associated bone variations were also assessed.ResultsACP pneumatization was observed in 30.8% of ACPs, with bilateral involvement in 5% of cases. The most frequent subtype was isolated optic strut pneumatization (subtype 1, 16%), followed by limited ACP involvement via the optic strut (subtype 2a, 6%). Planum-based and combined subtypes (3a and 4b) were uncommon (<4%). Male patients demonstrated significantly greater ACP base width (9.09 ± 1.61 mm vs. 8.54 ± 1.39 mm; p = 0.015) and length (13.23 ± 1.72 mm vs. 12.61 ± 1.64 mm; p = 0.010) than females. Middle clinoid processes and interclinoid calcifications were present in 5.8% and 8.8% of patients, respectively.ConclusionACP pneumatization, particularly via the optic strut, is a common anatomical variation. The proposed eight-subtype classification provides a nuanced framework for preoperative imaging description and communication. Although prior classifications were largely discussed in the context of transcranial approaches, the observed pneumatization patterns may also be relevant to endoscopic endonasal anatomy, particularly regarding optic canal exposure and potential sinonasal communication. Prospective surgical correlation studies are warranted to determine concordance with intraoperative findings and to clarify clinical relevance.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1788679</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1788679</link>
        <title><![CDATA[Staphylococcus aureus surgical site infection following unilateral biportal endoscopic spine surgery: a two-case report]]></title>
        <pubdate>2026-04-13T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Chunlin Hong</author><author>Lingfeng Chen</author><author>Huinuan Chen</author><author>Yahui Lin</author><author>Hong Lin</author><author>Zhirong Huang</author><author>Xuena Liu</author><author>Shiming Lin</author>
        <description><![CDATA[BackgroundSurgical site infection (SSI) is a serious complication of spinal surgery, including minimally invasive unilateral biportal endoscopic (UBE) procedures. Staphylococcus aureus (S. aureus) is a leading cause of such infections. This report analyses two cases of S. aureus SSI following UBE surgery.Case presentationTwo patients (one male and one female) aged 56 underwent elective UBE surgery. Both patients had inadequate preoperative skin preparation. The cases were complicated by intraoperative fluid leakage, which led to soaked surgical drapes. The second case also involved prolonged operative time and failure of postoperative wound care, with the patient performing unsterile dressing changes at home. Both patients developed deep SSIs caused by S. aureus, as confirmed by culture. This required readmission, endoscopic debridement and targeted antibiotic therapy.DiscussionThe differences in the antibiotic susceptibility profiles of the two cases suggest that the SSIs were likely caused by the patients’ own colonising flora. Key risk factors identified include inadequate skin preparation, intraoperative fluid leakage, prolonged surgery and breaches in postoperative care. These factors likely facilitated bacterial ingress and infection. In response, the institution implemented three key measures: direct nurse-led preoperative skin cleansing; increased surgical draping layers to prevent fluid saturation; and exclusive physician-performed postoperative dressings. Following these interventions, no new SSI cases were observed for over a year.ConclusionSSI after UBE surgery is multifactorial. A comprehensive strategy that addresses preoperative, intraoperative and postoperative protocols is crucial for prevention. The simple, targeted interventions described here effectively mitigated the risk of infection in our subsequent practice.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1720261</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1720261</link>
        <title><![CDATA[Case Report: Unilateral biportal endoscopic removal of migrated posterior lumbar interbody cages: a technical note]]></title>
        <pubdate>2026-04-10T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Wei Cheng</author><author>Dongmei Liu</author><author>Hailin Liang</author><author>Jiaming Liang</author><author>Chengyue Zhu</author><author>Rongxue Shao</author><author>Dong Wang</author><author>Hao Pan</author><author>Wei Zhang</author>
        <description><![CDATA[ObjectiveRevision surgery for the removal of a migrated interbody fusion cage is challenging due to scar tissue formation in the surgical area. This study introduces a unilateral biportal endoscopic (UBE) technique for the removal of a migrated fusion cage and reports the patient's clinical outcomes.MethodsA unilateral lumbar interbody fusion (ULIF) was performed via a trans-facet approach to extract the posterior lumbar interbody cage, thereby bypassing scar tissue from prior surgeries.ResultsThe patient's clinical symptoms improved significantly postoperatively, with no complications such as nerve injury or cerebrospinal fluid leakage. At the six-month postoperative follow-up, the patient's lumbar and leg VAS scores showed significant improvement, with no obvious signs of cage loosening observed.ConclusionUBE revision surgery may represent a safe and effective alternative for the removal of migrated posterior lumbar interbody cages.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1806822</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1806822</link>
        <title><![CDATA[Effect of dominant cement distribution zone on pain relief after unipedicular percutaneous vertebroplasty]]></title>
        <pubdate>2026-04-08T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Murat Özcan Yay</author><author>Melih Çetiner</author>
        <description><![CDATA[BackgroundCement location within the vertebral body may influence pain relief after unipedicular vertebroplasty. We tested a simple four-zone classification of dominant intravertebral cement distribution in osteoporotic vertebral compression fractures.MethodsWe retrospectively analyzed 425 patients treated from 2021 to 2024. On postoperative imaging, the vertebral body was divided into four equal zones (Zones 1–4) and the zone with the greatest cement accumulation was recorded. Pain was measured with the visual analog scale (VAS) before and after the procedure; change in VAS was the primary endpoint. Multivariable linear regression modeled change in VAS. Logistic regression modeled clinical response (change in VAS > 4).ResultsMean VAS decreased from 7.63 ± 0.84 to 3.31 ± 1.06 (p < 0.001), with mean change in VAS of 4.32 ± 1.38. Change in VAS differed across zones (p < 0.001), highest in Zone 4 and lowest in Zone 1. Complications occurred in 45.4% (primarily cement leakage) without permanent neurological deficit. In linear regression, dominant zone independently predicted change in VAS (B = 0.852; standardized β = 0.546; p < 0.001) and overall fit was strong (R² = 0.724; adjusted R² = 0.717). In logistic regression (n = 387), Omnibus χ² = 280.646 (df = 13, p < 0.001) and Nagelkerke R² = 0.729; zone, preoperative VAS, and cement volume were independent predictors. Calibration was acceptable (Hosmer–Lemeshow p = 0.941). Compared with Zone 4, Zones 1–3 showed lower odds of response; higher baseline VAS increased the odds.ConclusionsDominant cement zone strongly predicts pain improvement after unipedicular vertebroplasty and may serve as a practical procedural quality marker.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1734352</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1734352</link>
        <title><![CDATA[The value of intraoperative neuromonitoring combined with high-definition endoscopy in the operation of brachial plexus schwannoma]]></title>
        <pubdate>2026-04-08T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Yuxuan Xing</author><author>Junguo Wang</author><author>Xiaohui Shen</author><author>Dengbin Ma</author><author>Jiayi Li</author><author>Xiao Wu</author><author>Handong Wang</author><author>Yajun Gu</author><author>Xiaoyun Qian</author>
        <description><![CDATA[BackgroundTo investigate the value of intraoperative neuromonitoring (IONM) combined with high-definition endoscopy in surgical treatment of brachial plexus schwannoma.MethodsA retrospective analysis was conducted on twenty patients diagnosed with brachial plexus schwannoma from January 2020 to December 2024. All cases were treated surgically with IONM combined with high-definition endoscopy. Intraoperative and postoperative nerve function were assessed to evaluate the value of this combined approach during surgery.ResultsAll twenty patients underwent complete intracapsular tumor resection. Two patients developed numbness in the fingers, and one patient developed numbness in the shoulder. Postoperative motor function was unaffected in all patients. No tumor recurrence was observed during a follow-up period from one to four years.ConclusionIONM combined with high-definition endoscopy helps to better identify nerve trajectories, plan tumor envelope incision pathways, detect early nerve injuries and assess the prognosis of nerve conduction function. This procedure also contributes to improving patient's quality of life.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1709333</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1709333</link>
        <title><![CDATA[Case Report: Unclassifiable cerebellar high-grade neuroepithelial tumor with a CCDC6::RET fusion manifesting explosive recurrence]]></title>
        <pubdate>2026-04-08T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Moksada Regmi</author><author>Shikun Liu</author><author>Ying Xiong</author><author>Junyi Liu</author><author>Zihan Zhao</author><author>Xu Zhang</author><author>Chenlong Yang</author><author>Sino-Uzbek Regenerative Therapy Consortium (SURE) </author>
        <description><![CDATA[A 20-year-old woman presented with a 1-month history of positional vertigo, occipital headaches, and progressive gait ataxia. Neuroimaging demonstrated a 3.7 × 4.2 × 3.3 cm heterogeneously enhancing mass in the left cerebellar hemisphere with fourth-ventricle compression, approximately 8 mm tonsillar herniation, and obstructive hydrocephalus. Urgent resection was performed through a midline suboccipital approach with neuronavigation and fluorescein guidance, achieving gross total removal. Histopathology showed an undifferentiated high-grade neuroepithelial malignancy with brisk mitotic activity and necrosis. The Ki-67 labeling index exceeded 80% in hotspot regions. Immunophenotyping showed partial glial marker expression and neuroendocrine marker expression; INI1 was retained and other markers did not support more common defined entities. Hybrid-capture DNA and RNA next-generation sequencing identified TP53 c.524G > A (p.R175H), amplification of CDK4 and AURKA, and an in-frame CCDC6 (exon 1)::RET (exon 12) fusion. Based on the integrated histologic, immunophenotypic, and molecular findings available, the tumor could not be assigned to a specific WHO-defined CNS tumor entity. Despite gross total resection and postoperative oncologic management, the tumor recurred rapidly with leptomeningeal dissemination and progressed to multifocal posterior fossa and brainstem disease. The patient died five months after diagnosis. This case illustrates the diagnostic and therapeutic challenges posed by rare, highly aggressive CNS neoplasms that do not map to a WHO-defined entity on available testing and highlights the potential clinical relevance of identifying actionable RET fusions in high-grade neuroepithelial tumors.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1776885</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1776885</link>
        <title><![CDATA[Elbow flexion recovery after intercostal nerve transfer in elderly patients: a clinical experience report]]></title>
        <pubdate>2026-04-08T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Evelina Llorian</author><author>Gabriela Magalhães</author><author>Ingrid Espíndola</author><author>Fernando Guedes</author>
        <description><![CDATA[IntroductionRestoration of elbow flexion is a primary goal in the surgical management of complete traumatic brachial plexus injuries (BPIs). When proximal donor nerves are unavailable, intercostal nerve (ICN) transfer to the musculocutaneous nerve (MCN) represents a well-established reconstructive option. However, elderly patients are markedly underrepresented in published series, and outcomes in this population remain poorly defined. The objective of this study was to evaluate clinical outcomes of ICN-to-MCN transfer in elderly patients and to identify perioperative factors associated with meaningful functional recovery.MethodsA retrospective case series was conducted. Over a 30-year period, four consecutive patients aged over 60 years who underwent ICN-to-MCN transfer for complete traumatic brachial plexus avulsion were identified. Demographic characteristics, surgical timing, coaptation strategy, and functional outcomes were analyzed.ResultsElderly patients accounted for less than 1.6% of more than 250 ICN-to-MCN transfers performed during the study period. All patients were male and sustained complete brachial plexus injuries following motorcycle accidents. One patient who underwent early reconstruction within 2 months of trauma, allowing direct neurorrhaphy without grafting, achieved useful elbow flexion (M4). This patient demonstrated preserved muscle bulk, normal testosterone levels, and strong adherence to postoperative motor rehabilitation. In contrast, delayed surgery beyond 5 months, particularly when nerve grafts were required, resulted in limited or absent recovery (M0–M2).ConclusionsICN-to-MCN transfer remains a viable reconstructive option in carefully selected elderly patients. Favorable outcomes are influenced by modifiable factors, particularly earlier reconstruction, feasibility of tension-free coaptation, preserved muscle quality, and structures postoperative rehabilitation. While chronological age alone should not be considered a contraindication, the therapeutic window for successful nerve transfer is substantially narrower in older individuals.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1792515</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1792515</link>
        <title><![CDATA[Intraoperative application of FFR pressure wire and FLOW800 imaging as predictors of postoperative cerebral perfusion abnormalities in Moyamoya disease]]></title>
        <pubdate>2026-04-01T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Huan Li</author><author>Shubin Tan</author><author>Mohamed Helmy</author><author>Donglei Song</author><author>Bin Xu</author><author>Wei Wang</author>
        <description><![CDATA[ObjectiveTo evaluate whether intraoperative fractional flow reserve (FFR) pressure wire measurements combined with FLOW800 imaging analysis effectively predict postoperative cerebral perfusion abnormalities following superficial temporal artery to middle cerebral artery (STA–MCA) bypass surgery in patients with Moyamoya disease (MMD).MethodsA retrospective analysis was conducted on 26 patients diagnosed with MMD who underwent STA–MCA bypass at our institution between November 2023 and January 2025. Intraoperative graft pressures were assessed using FFR pressure wires. Concurrently, FLOW800 imaging provided quantitative microcirculatory parameters, including delay time (DT), flow velocity, rise time (RT), and fluorescence intensity. Postoperative cerebral perfusion-related complications were documented. ROC analyses were reported with 95% confidence intervals to evaluate the predictive value of intraoperative parameters.ResultsPostoperative cerebral perfusion abnormalities occurred in 9 out of 26 patients (34.6%). Among them, 3 patients (11.5%) had diffusion-weighted MRI (DWI)-confirmed acute ischemic lesions (major complications), whereas the remaining 6 patients experienced transient neurological symptoms that completely resolved within 2 weeks to 1 month without radiographic infarction. A higher pressure gradient across the bypass graft (ΔP) and prolonged rise time (RT) in the proximal recipient artery significantly correlated with postoperative perfusion abnormalities (p < 0.05). A ΔP cutoff >32 mmHg showed a sensitivity of 77.8% and a specificity of 64.7%. The combined predictive capability of ΔP and RT yielded an area under the receiver operating characteristic (ROC) curve (AUC) of 0.82 (95% CI, 0.61–0.99), surpassing the predictive value of either parameter alone (AUC 0.79 for ΔP and 0.79 for RT).ConclusionsIntraoperative monitoring with FFR pressure wire combined with FLOW800 imaging may help identify MMD patients at increased risk of early postoperative cerebral perfusion abnormalities after STA–MCA bypass. The integration of ΔP and RT appears to improve predictive accuracy and may support perioperative risk stratification, although larger prospective studies are required before routine decision-making can be recommended.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fsurg.2026.1782293</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fsurg.2026.1782293</link>
        <title><![CDATA[Comparative effectiveness of neuroendoscopic surgery and stereotactic aspiration for brain hemorrhage]]></title>
        <pubdate>2026-04-01T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Hazrat Jalal</author><author>Huikai Zhang</author><author>Long Zhou</author><author>Zhiyang Li</author><author>Jiajun Wei</author><author>Shenqi Zhang</author><author>Qiang Cai</author>
        <description><![CDATA[BackgroundIntraparenchymal hemorrhage (IPH) involving the cerebrum, cerebellum, and brainstem is a critical condition with high mortality. While minimally invasive surgical techniques are widely utilized, the comparative effectiveness of neuroendoscopic surgery (NS) vs. stereotactic aspiration (SA) across different anatomical locations remains underexplored. This study aims to retrospectively compare the effectiveness and safety of NS and SA in a cohort encompassing different IPH locations.MethodsA single-center retrospective analysis was conducted on 199 patients with IPH (NS: n = 97; SA: n = 102) treated between 2019 and 2023. The primary outcome was the median hematoma reduction rate (%) and included acute neurological improvement [change in Glasgow Coma Scale (GCS) at 24 h postoperatively]. Secondary outcome: functional independence [modified Rankin Scale (mRS) 0–3] at discharge. Multivariate logistic regression adjusted for baseline imbalances in age and hypertension. Radiologic evacuation and neurological change were evaluated as early surrogate endpoints and do not directly measure long-term functional recovery.ResultsOverall, NS demonstrated a significantly higher median hematoma reduction rate compared to SA (92.90% vs. 22.20%, p < 0.001) and greater acute neurological improvement (median ΔGCS 4.0 vs. 0.5 points, p < 0.001). These trends were consistently observed across deep-seated, lobar, cerebellar, and brainstem subgroups (all p < 0.05). Functional independence at discharge was achieved by 27.8% in the NS group vs. 15.7% in the SA group (p = 0.040). Furthermore, NS was associated with significantly lower symptomatic rebleeding (7.2% vs. 24.5%, p < 0.001) and 30-day mortality (9.3% vs. 22.5%, p = 0.012).ConclusionThis retrospective analysis suggests that NS is associated with higher evacuation efficiency and more pronounced early neurological recovery across various IPH locations compared to SA. While prospective validation is required to confirm long-term functional trajectories, these findings highlight the potential advantages of direct visualization and active hemostasis in managing IPH across different anatomical locations.]]></description>
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