AUTHOR=Sadighara Parisa , Rostami Shahrbano , Shafaroodi Hamed , Sarshogi Ali , Mazaheri Yeghaneh , Sadighara Melina 

TITLE=The effect of residual antibiotics in food on intestinal microbiota: a systematic review

JOURNAL=Frontiers in Sustainable Food Systems

VOLUME=Volume 7 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/sustainable-food-systems/articles/10.3389/fsufs.2023.1163885

DOI=10.3389/fsufs.2023.1163885

ISSN=2571-581X

ABSTRACT=The gut microbiota may be altered following changes in diet or exposure to drugs. Humans can be exposed to antibiotic residue in food. People may be exposed to these compounds for years. But in determining the maximum residue level (MRL), the effects of antibiotic residue on the intestinal microbiota are not investigated. Evidence suggests that antibiotics in small amounts also lead to changes in the microbial population residing in the intestines. For this purpose, a search was made in the databases with keywords antibiotic, veterinary antibiotic, food, residue, microbiome, and microbiota. The main criterion of this research was to investigate the effects of antibiotics at low doses. The investigated doses of each of the antibiotics in the studies were compared with their MRL in food. The most significant change in the structure and function of the microbiota was made by tetracycline, sulfamethoxazole, cefquinome, florfenicol and tylosin. The lowest observed effect was related to the antibiotics fosfomycin and amoxicillin. Therefore, it is necessary to inform the breeders and competent authorities in order to comply with the principles of treatment.