AUTHOR=Piette Charlotte , Gervasi Nicolas , Venance Laurent 

TITLE=Synaptic plasticity through a naturalistic lens

JOURNAL=Frontiers in Synaptic Neuroscience

VOLUME=Volume 15 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/synaptic-neuroscience/articles/10.3389/fnsyn.2023.1250753

DOI=10.3389/fnsyn.2023.1250753

ISSN=1663-3563

ABSTRACT=From the myriad of studies on neuronal plasticity, investigating its underlying molecular mechanisms up to its behavioural relevance, a very complex landscape has emerged. Recent efforts have been achieved towards more naturalistic investigations as an attempt to better capture the synaptic plasticity underpinning of learning and memory, which has been fostered by the development of in vivo electrophysiological and imaging tools. In this review, we examine these naturalistic investigations, by devoting a first part on synaptic plasticity rules issued from naturalistic or in vivo-like activity patterns. We next give an overview of the novel tools, which enable an increased spatio-temporal specificity for detecting and manipulating plasticity expressed at individual spines up to neuronal circuit level during behaviour. Finally, we put particular emphasis on works considering brain-body communication loops, such as macroscale contributors to synaptic plasticity, body internal states and brain energy metabolism.