AUTHOR=Verma Meghna , Gall Louis , Biasetti Jacopo , Di Veroli Giovanni Y. , Pichardo-Almarza Cesar , Gibbs Megan A. , Kimko Holly 

TITLE=Quantitative systems modeling approaches towards model-informed drug development: Perspective through case studies

JOURNAL=Frontiers in Systems Biology

VOLUME=Volume 2 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2022.1063308

DOI=10.3389/fsysb.2022.1063308

ISSN=2674-0702

ABSTRACT=Quantitative systems pharmacology modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions. In this paper, we present examples of QSP modeling applications to highlight the notable contributions and opportunities that these approaches are to offer during the drug development process. We also consider the barriers to successful applications; outline the factors required to support the success of these modeling approaches; and provide insights for a strategy to enhance acceptance by the regulatory agencies.