The Integrative Genetics and Genomics section of Frontiers in Systems Biology publishes high-quality fundamental, applied, and interdisciplinary research across the field of systems genetics, a topical and growing subdiscipline of genetics that uses systems biology to gain insights into the genome.Read More
The Integrative Genetics and Genomics section of Frontiers in Systems Biology publishes high-quality fundamental, applied, and interdisciplinary research across the field of systems genetics, a topical and growing subdiscipline of genetics that uses systems biology to gain insights into the genome. Systems genetics has been stimulated and driven by the development of high-throughput techniques and it has become very influential and popular across molecular, cellular, biomedical, pharmacological, agricultural, and social sciences. Different from traditional reductionist-based genetic approaches that focus on the characterization of individual genetic factors for complex traits and diseases, systems genetics strives to chart a systematic atlas of how multiple factors work together to mediate trait phenotypes. The Integrative Genetics and Genomics section solicits significant advances in areas including, but not limited to:
Genome-wide association studies aimed to disentangle the genetic complexity of phenotypic traits and diseases
Pairwise and high-order genetic interactions that better interpret phenotypic variation
Missing heritability detection by a combined pool of genetic and epigenetic variants
Genotype-phenotype mapping through intermediate phenotypes, such as transcripts, proteins or metabolites
Network modeling and applications to understand the flow of biological information that underlies complex traits
Modeling the multilocus control of genotype-environment interactions
Multidisciplinary integration of diverse concepts into a more effective genetic, genomic, and bioinformatics tool
Statistical and computational methodologies of unlocking high-dimensional genetic data
Experimental discoveries of genetic inheritance and causes for complex traits or diseases from various species
This section publishes papers that understand genetic complexity from a holistic, systems-oriented perspective. Studies that use a reductionist approach for genetic and genomic research do not fall within the scope of this section and should be submitted to more specialized journals. This section will publish both theoretical and experimental research into systems genetics, but will operate in close collaboration with our sister journals, Frontiers in Genetics, Frontiers in Plant Science, and Frontiers in Ecology & Evolution, to consider practical applications of systems tools to genetic mapping, plant genetics, and evolutionary genetics.
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Integrative Genetics and Genomics welcomes submissions of the following article types: Brief Research Report, Case Report, Clinical Trial, Community Case Study, Data Report, Editorial, Field Grand Challenge, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Policy and Practice Reviews, Policy Brief, Protocols, Review, Specialty Grand Challenge, Systematic Review and Technology and Code.
All manuscripts must be submitted directly to the section Integrative Genetics and Genomics, where they are peer-reviewed by the Associate and Review Editors of the specialty section.
Avenue du Tribunal Fédéral 34
CH – 1005 Lausanne
Tel +41(0)21 510 17 40
Fax +41 (0)21 510 17 01
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