Frontiers in Systems Biology | Integrative Genetics and Genomics

Original Research

Published on 30 Jul 2025

A Pseudomonas fluorescens AND-gate biosensor for protein expression at plant root proximity

in Integrative Genetics and Genomics

Nico van Donk
Antoine Raynal
Enrique Asin-Garcia

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1620608

745 views

Methods

Published on 18 Nov 2024

An exploration of testing genetic associations using goodness-of-fit statistics based on deep ReLU neural networks

in Integrative Genetics and Genomics

Xiaoxi Shen
Xiaoming Wang

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1460369

807 views
1 citation

Mini Review

Published on 13 Nov 2024

Interplay of circular RNAs in gastric cancer - a systematic review

in Integrative Genetics and Genomics

Dipanjan Guha
Jit Mondal
Anirban Nandy
Sima Biswas
Angshuman Bagchi

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1497510

816 views
1 citation

Mini Review

Published on 03 Jun 2024

De novo prediction of functional effects of genetic variants from DNA sequences based on context-specific molecular information

in Integrative Genetics and Genomics

Jiaxin Yang
Sikta Das Adhikari
Hao Wang
Binbin Huang
Wenjie Qi
Yuehua Cui
Jianrong Wang

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1402664

2,402 views
1 citation

Original Research

Published on 25 Apr 2024

Elucidating a genomic signature associated with behavioral and executive function after moderate to severe pediatric TBI: a systems biology informed approach

in Integrative Genetics and Genomics

Brad G. Kurowski
Amery Treble-Barna
Valentina Pilipenko
Lisa J. Martin
Anil G. Jegga
Aimee E. Miley
Nanhua Zhang
Anthony Fabio
Ranjit S. Chima
Anna-Lynne R. Adlam

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1293265

1,593 views

Methods

Published on 21 Mar 2024

A robust ensemble feature selection approach to prioritize genes associated with survival outcome in high-dimensional gene expression data

in Integrative Genetics and Genomics

Phi Le
Xingyue Gong
Leah Ung
Hai Yang
Bridget P. Keenan
Li Zhang
Tao He

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1355595

1,931 views
3 citations

Original Research

Published on 08 Aug 2023

A microbiota-epigenetic circuit controls systematic circadian programs in the gut epithelium

in Integrative Genetics and Genomics

Junjie Ma
Jianglin Zhang
Zheng Kuang

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1175306

2,509 views
3 citations

Mini Review

Published on 21 Apr 2023

Single-cell technologies for multimodal omics measurements

in Integrative Genetics and Genomics

Dongsheng Bai
Chenxu Zhu

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1155990

4,179 views

Original Research

Published on 11 Jan 2023

scMODD: A model-driven algorithm for doublet identification in single-cell RNA-sequencing data

in Integrative Genetics and Genomics

Xinye Zhao
Alexander Du
Peng Qiu

Frontiers in Systems Biology

doi 10.3389/fsysb.2022.1082309

2,798 views
1 citation

Mini Review

Published on 14 Dec 2022

A brief account on enzyme mining using metagenomic approach

in Integrative Genetics and Genomics

Tithi Patel
Hiral G. Chaudhari
Vimalkumar Prajapati
Swati Patel
Vaibhavkumar Mehta
Niti Soni

Frontiers in Systems Biology

doi 10.3389/fsysb.2022.1046230

9,182 views
18 citations

Mini Review

Published on 12 Dec 2022

Genome-wide association studies of viral infections—A short guide to a successful experimental and statistical analysis

in Integrative Genetics and Genomics

Anamarija Butković
Santiago F. Elena

Frontiers in Systems Biology

doi 10.3389/fsysb.2022.1005758

7,248 views
1 citation

Original Research

Published on 24 Oct 2022

Comparison of cell type annotation algorithms for revealing immune response of COVID-19

in Integrative Genetics and Genomics

Congmin Xu
Huyun Lu
Peng Qiu

Frontiers in Systems Biology

doi 10.3389/fsysb.2022.1026686

4,167 views
3 citations

Mini Review

Published on 18 Oct 2022

Distal and proximal control of rhythmic gene transcription

in Integrative Genetics and Genomics

Abraham Román-Figueroa
Luis Tenorio-Hernández
Mayra Furlan-Magaril

Frontiers in Systems Biology

doi 10.3389/fsysb.2022.1026424

3,802 views

Review

Published on 22 Jul 2022

A complete guide to human microbiomes: Body niches, transmission, development, dysbiosis, and restoration

in Integrative Genetics and Genomics

Jelissa Reynoso-García
Angel E. Miranda-Santiago
Natalie M. Meléndez-Vázquez
Kimil Acosta-Pagán
Mitchell Sánchez-Rosado
Jennifer Díaz-Rivera
Angélica M. Rosado-Quiñones
Luis Acevedo-Márquez
Lorna Cruz-Roldán
Eduardo L. Tosado-Rodríguez

Frontiers in Systems Biology

doi 10.3389/fsysb.2022.951403

33,699 views
52 citations

Opinion

Published on 04 Jul 2022

Old Circular RNAs, New Habits: Repurposing Noncoding RNAs in Parasitic Amebozoa

in Integrative Genetics and Genomics

Gretter González-Blanco
José Manuel Jáuregui-Wade
Tea Anastasia Ruiz-Luis
Yumiko Saito-Nakano
Jesús Valdés

Frontiers in Systems Biology

doi 10.3389/fsysb.2022.951295

1,151 views

Original Research

Published on 02 Jun 2022

Robust Behrens–Fisher Statistic Based on Trimmed Means and Its Usefulness in Analyzing High-Throughput Data

in Integrative Genetics and Genomics

Guolian Kang
Sedigheh S. Mirzaei
Hui Zhang
Liang Zhu
Shesh N. Rai
Deo Kumar Srivastava

Frontiers in Systems Biology

doi 10.3389/fsysb.2022.877601

1,219 views