Frontiers in Systems Biology | Translational Systems Biology and In Silico Trials

Original Research

Published on 15 Sep 2025

Digital patient modeling identifies predictive biomarkers of regorafenib response in elderly metastatic colorectal cancer

in Translational Systems Biology and In Silico Trials

Juan Manuel García-Illarramendi
Pedro Matos-Filipe
Jose Manuel Mas
Judith Farrés
Xavier Daura

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1648559

601 views

Original Research

Published on 14 Aug 2025

A model-based design strategy to engineer miRNA-regulated detection systems

in Translational Systems Biology and In Silico Trials

Renske J. Verkuijlen
Robert W. Smith

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1601854

1,032 views

Review

Published on 07 Jan 2025

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions

in Translational Systems Biology and In Silico Trials

Jun Sun
Masanori Aikawa
Hassan Ashktorab
Noam D. Beckmann
Michael L. Enger
Joaquin M. Espinosa
Xiaowu Gai
Benjamin D. Horne
Paul Keim
Jessica Lasky-Su

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1422384

5,035 views
1 citation

Methods

Published on 12 Sep 2024

Building virtual patients using simulation-based inference

in Translational Systems Biology and In Silico Trials

Nathalie Paul
Venetia Karamitsou
Clemens Giegerich
Afshin Sadeghi
Moritz Lücke
Britta Wagenhuber
Alexander Kister
Markus Rehberg

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1444912

3,042 views

Perspective

Published on 12 Jul 2024

Coupling quantitative systems pharmacology modelling to machine learning and artificial intelligence for drug development: its pAIns and gAIns

in Translational Systems Biology and In Silico Trials

Núria Folguera-Blasco
Florencia A. T. Boshier
Aydar Uatay
Cesar Pichardo-Almarza
Massimo Lai
Jacopo Biasetti
Richard Dearden
Megan Gibbs
Holly Kimko

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1380685

4,544 views
2 citations

Original Research

Published on 04 Jul 2024

Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease

in Translational Systems Biology and In Silico Trials

John S. Clemmer
W. Andrew Pruett
Robert L. Hester

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1327357

2,083 views
1 citation

Technology and Code

Published on 17 Jun 2024

PdPANA: phagemid display as peptide array for neutralizing antibodies, an engineered in silico vaccine candidate against COVID-19

in Translational Systems Biology and In Silico Trials

Javier Uzcátegui
Khaleel Mullah
Daniel Buvat de Virgini
Andrés Mendoza
Rafael Urdaneta
Alejandra Naranjo

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1309891

2,243 views

Original Research

Published on 03 Apr 2024

Intein-mediated thyroid hormone biosensors: towards controlled delivery of hormone therapy

in Translational Systems Biology and In Silico Trials

Quim Martí-Baena
Andreu Pascuet-Fontanet
Tomas Berjaga-Buisan
Miriam Caravaca-Rodríguez
Jaume Puig-Costa-Jussà
Avencia Sanchez-Mejias
Dimitrije Ivančić
Sira Mogas-Díez
Marc Güell
Javier Macia

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1270071

3,060 views

Original Research

Published on 25 Mar 2024

Mathematical modeling of temperature-induced circadian rhythms

in Translational Systems Biology and In Silico Trials

Lingjun Lu
Yannuo Li
Rene Schloss
Ioannis P. Androulakis

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1256398

2,497 views
1 citation

Original Research

Published on 08 Mar 2024

Uncertainty quantified discovery of chemical reaction systems via Bayesian scientific machine learning

in Translational Systems Biology and In Silico Trials

Emily Nieves
Raj Dandekar
Chris Rackauckas

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1338518

5,880 views
5 citations

Perspective

Published on 08 Mar 2024

Advancing precision medicine therapeutics for Parkinson’s utilizing a shared quantitative systems pharmacology model and framework

in Translational Systems Biology and In Silico Trials

Christopher Denaro
Diane Stephenson
Martijn L. T. M. Müller
Benedetto Piccoli
Karim Azer

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1351555

3,635 views
5 citations

Original Research

Published on 01 Mar 2024

Pareto task inference analysis reveals cellular trade-offs in diffuse large B-Cell lymphoma transcriptomic data

in Translational Systems Biology and In Silico Trials

Jonatan Blais
Julie Jeukens

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1346076

1,837 views

Original Research

Published on 22 Jan 2024

A framework for multi-scale intervention modeling: virtual cohorts, virtual clinical trials, and model-to-model comparisons

in Translational Systems Biology and In Silico Trials

Christian T. Michael
Sayed Ahmad Almohri
Jennifer J. Linderman
Denise E. Kirschner

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1283341

3,124 views
12 citations

Original Research

Published on 08 Jan 2024

Metabolic perturbation studies using a Nash Equilibrium model of liver machine perfusion: modeling oxidative stress and effect of glutathione supplementation

in Translational Systems Biology and In Silico Trials

Angelo Lucia
Korkut Uygun

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1260315

1,104 views

Editorial

Published on 29 Sep 2023

Editorial: Virtual patients and digital twins in the systems analysis of drug discovery and development

in Translational Systems Biology and In Silico Trials

Chen Zhao
Hua He
Huilin Ma

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1293076

1,916 views
1 citation

Editorial

Published on 29 Sep 2023

Editorial: Systems biology, women in science 2021/22: translational systems biology and in silico trials

in Translational Systems Biology and In Silico Trials

Jane A. Leopold
Madhavi K. Ganapathiraju
Naveena Yanamala

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1293298

1,107 views