AUTHOR=Liu Xiao , Chang Catie , Duyn Jeff H.

TITLE=Decomposition of Spontaneous Brain Activity into Distinct fMRI Co-activation Patterns

JOURNAL=Frontiers in Systems Neuroscience

VOLUME=Volume 7 - 2013

YEAR=2013

URL=https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2013.00101

DOI=10.3389/fnsys.2013.00101

ISSN=1662-5137

ABSTRACT=Recent fMRI studies have shown that analysis of the human brain’s spontaneous activity may provide a powerful approach to reveal its functional organization. Dedicated methods have been proposed to investigate co-variation of signals from different brain regions, with the goal of revealing neuronal networks that may serve specialized functions. However, these analysis methods generally do not take into account a potential non-stationary (variable) interaction between brain regions, and as a result have limited effectiveness. To address this, we propose a novel analysis method that uses clustering analysis to sort and selectively average fMRI activity time frames to produce a set of co-activation patterns. Compared to the established networks extracted with conventional analysis methods, these co-activation patterns demonstrate novel network features with apparent relevance to the brain’s functional organization.