AUTHOR=Dash Suryadeep , Nazari Sina Alipour , Yan Xiaogang , Wang Hongying , Crawford J. Douglas TITLE=Superior Colliculus Responses to Attended, Unattended, and Remembered Saccade Targets during Smooth Pursuit Eye Movements JOURNAL=Frontiers in Systems Neuroscience VOLUME=Volume 10 - 2016 YEAR=2016 URL=https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2016.00034 DOI=10.3389/fnsys.2016.00034 ISSN=1662-5137 ABSTRACT=

In realistic environments, keeping track of multiple visual targets during eye movements likely involves an interaction between vision, top-down spatial attention, memory, and self-motion information. Recently we found that the superior colliculus (SC) visual memory response is attention-sensitive and continuously updated relative to gaze direction. In that study, animals were trained to remember the location of a saccade target across an intervening smooth pursuit (SP) eye movement (Dash et al., 2015). Here, we modified this paradigm to directly compare the properties of visual and memory updating responses to attended and unattended targets. Our analysis shows that during SP, active SC visual vs. memory updating responses share similar gaze-centered spatio-temporal profiles (suggesting a common mechanism), but updating was weaker by ~25%, delayed by ~55 ms, and far more dependent on attention. Further, during SP the sum of passive visual responses (to distracter stimuli) and memory updating responses (to saccade targets) closely resembled the responses for active attentional tracking of visible saccade targets. These results suggest that SP updating signals provide a damped, delayed estimate of attended location that contributes to the gaze-centered tracking of both remembered and visible saccade targets.