AUTHOR=Zarei Mohammad , Parto Dezfouli Mohsen , Jahed Mehran , Daliri Mohammad Reza 

TITLE=Adaptation Modulates Spike-Phase Coupling Tuning Curve in the Rat Primary Auditory Cortex

JOURNAL=Frontiers in Systems Neuroscience

VOLUME=Volume 14 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2020.00055

DOI=10.3389/fnsys.2020.00055

ISSN=1662-5137

ABSTRACT=Adaptation is a well-known mechanism to reduce neural response both in spiking activity and local field potential (LFP). We previously showed this reduction effect in the tuning curve of primary auditory cortex. Moreover, we revealed that a repeated stimulus reduces the neural response in terms of spike-phase coupling (SPC). In the current study, we investigated the effect of adaptation on the SPC tuning curve. To this end, we used the phase locking value (PLV) method to estimate the spike-LFP coupling of the data which was obtained by simultaneous recording of four single-electrodes in the primary auditory cortex of 15 rats. We first investigated whether the neural system may use spike-LFP phase coupling in the primary auditory cortex to encode sensory information. Secondly, we examined the effect of adaptation on this potential SPC tuning. Our data showed that the coupling between spikes’ times and the LFP phase of beta oscillations represents sensory information (different stimulus frequencies), with an inverted bell-shaped tuning curve. Furthermore, we showed that adaptation to a specific frequency modulates SPC tuning curve of the adapter and its neighboring frequencies. These findings could be useful for interpretation of feature representation in terms of SPC and the underlying neural mechanism of adaptation.