Frontiers in Toxicology | New and Recent Articles https://www.frontiersin.org/journals/toxicology RSS Feed for Frontiers in Toxicology | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-13T06:58:08.313+00:00 60 https://www.frontiersin.org/articles/10.3389/ftox.2026.1639389 https://www.frontiersin.org/articles/10.3389/ftox.2026.1639389 <![CDATA[Next-generation full-thickness human skin models produced using 3D electrospun scaffolds and animal-component-free culture media]]> 2026-05-13T00:00:00Z Original Research Patrick J. HaydenJayashree ChakravartyRayan K. HodrojSar R. LindnerLisa M. FitzgeraldJacob T. Le DoHsin Tzu KengVivek PatelHolger P. BehrsingMatthew D. Phaneuf https://www.frontiersin.org/articles/10.3389/ftox.2026.1800157 https://www.frontiersin.org/articles/10.3389/ftox.2026.1800157 <![CDATA[Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays]]> 2026-05-12T00:00:00Z Review Julia Vanessa SpänleLisa Maria HaiberBettina Seeger https://www.frontiersin.org/articles/10.3389/ftox.2026.1823460 https://www.frontiersin.org/articles/10.3389/ftox.2026.1823460 <![CDATA[Botulinum toxin type E alleviates trigeminal neuropathic pain via modulation of the HIF-1α–NLRP3 pathway]]> 2026-05-12T00:00:00Z Original Research JoYoung SonYuMi KimJinSook JuJaeYoung KimJeongSun NamYoonKyoung ChaDongKuk Ahn https://www.frontiersin.org/articles/10.3389/ftox.2026.1774625 https://www.frontiersin.org/articles/10.3389/ftox.2026.1774625 <![CDATA[PFOA/PFOS induce ferroptosis in bladder epithelial cells through inhibition of ACSL4 ubiquitination]]> 2026-05-11T00:00:00Z Original Research Hao XuZhihua YeJuan LiuMengwei LiuQinghua HuYi LiuQiankun ZhangJian OuXin ShenXiaogang Chen https://www.frontiersin.org/articles/10.3389/ftox.2026.1771011 https://www.frontiersin.org/articles/10.3389/ftox.2026.1771011 <![CDATA[Machine learning-integrated network toxicology uncovers glioma targets of DEHP]]> 2026-05-08T00:00:00Z Original Research Ren LiChaomin RenLu HeShule WangGeng Guo https://www.frontiersin.org/articles/10.3389/ftox.2026.1829326 https://www.frontiersin.org/articles/10.3389/ftox.2026.1829326 <![CDATA[Bridging gaps between scientific research and regulatory decision-making in Europe: roles of academia, risk assessors, and policymakers]]> 2026-05-04T00:00:00Z Policy and Practice Reviews Ana Fernandez-AgudoHannah LesterJose V. TarazonaFernando Rivero-Pino https://www.frontiersin.org/articles/10.3389/ftox.2026.1753174 https://www.frontiersin.org/articles/10.3389/ftox.2026.1753174 <![CDATA[Visual–acoustic thigmotaxis in zebrafish larvae: a high throughput NAM for neurotoxicity assessment]]> 2026-05-04T00:00:00Z Original Research Monica Torres-RuizMaria Muñoz-PalenciaAntonio De la ViejaAna I. Cañas-Portilla https://www.frontiersin.org/articles/10.3389/ftox.2026.1790669 https://www.frontiersin.org/articles/10.3389/ftox.2026.1790669 <![CDATA[Next generation validation for next generation risk assessment]]> 2026-05-01T00:00:00Z Review Karolina KopańskaThomas Hartung https://www.frontiersin.org/articles/10.3389/ftox.2026.1818582 https://www.frontiersin.org/articles/10.3389/ftox.2026.1818582 <![CDATA[Toxic or non-toxic: a critical assessment of the contradictory results for selected graphene family materials]]> 2026-04-29T00:00:00Z Review Charlene AndraosVictor WepenerMary Gulumian https://www.frontiersin.org/articles/10.3389/ftox.2026.1784229 https://www.frontiersin.org/articles/10.3389/ftox.2026.1784229 <![CDATA[A new in vitro rat liver platform capturing biological diversity for drug-induced liver injury assessment and reduction of animal use in drug discovery and development]]> 2026-04-28T00:00:00Z Original Research Pralhad WangikarSara CherradiPradhnya ChoudhariAditi WangikarVaibhav MadiwalSalomé RouxNisha BanerjeePranav PanzadePallavi GangardeNithish KannanHong Tuan Duong https://www.frontiersin.org/articles/10.3389/ftox.2026.1653106 https://www.frontiersin.org/articles/10.3389/ftox.2026.1653106 <![CDATA[On the background of plastics nanoparticles in our research]]> 2026-04-23T00:00:00Z Brief Research Report Martin LundqvistJing HuaMikael T. EkvallTommy Cedervall https://www.frontiersin.org/articles/10.3389/ftox.2026.1782869 https://www.frontiersin.org/articles/10.3389/ftox.2026.1782869 <![CDATA[Assessing drinking water treatment efficiency using passive sampling and cell-based bioassays]]> 2026-04-23T00:00:00Z Original Research Martin EzechiášMichaela Hegrová HelusováGabriela HorákováEva CséfalvayJaroslav SemerádIvana KopeckáTomáš Cajthaml https://www.frontiersin.org/articles/10.3389/ftox.2026.1727831 https://www.frontiersin.org/articles/10.3389/ftox.2026.1727831 <![CDATA[Acute anti-proliferative and anti-migratory effects of cannabidiol on C6 rat glioma, SH-SY5Y human neuroblastoma, and HT22 mouse hippocampal neuronal cell cultures]]> 2026-04-21T00:00:00Z Original Research Kittikun ViwatpinyoSujira MukdaAktsar Roskiana AhmadSakan Warinhomhoun https://www.frontiersin.org/articles/10.3389/ftox.2026.1796387 https://www.frontiersin.org/articles/10.3389/ftox.2026.1796387 <![CDATA[Examining in vivo effects of silychristin, a potent in vitro inhibitor of thyroid hormone transporter MCT8]]> 2026-04-21T00:00:00Z Original Research Kostja RenkoRyne ThomasMaryAnn HawksJermaine FordJosef KöhrleMarta AxelstadMary E. Gilbert https://www.frontiersin.org/articles/10.3389/ftox.2026.1735718 https://www.frontiersin.org/articles/10.3389/ftox.2026.1735718 <![CDATA[Protein quality and allergenicity assessment of chia seeds (Salvia hispanica): a molecular perspective on novel food safety]]> 2026-04-20T00:00:00Z Original Research Luisa CalcinaiSara CutroneoIlaria PuxedduSimon DirrÖzlem Özmutlu KarsliogluTullia Tedeschi https://www.frontiersin.org/articles/10.3389/ftox.2026.1812922 https://www.frontiersin.org/articles/10.3389/ftox.2026.1812922 <![CDATA[Transcriptomic and functional profiling of endothelial dysfunction induced by polystyrene nanoplastics]]> 2026-04-17T00:00:00Z Original Research Joan Martín-PérezAliro VillacortaJavier Gutiérrez-GarcíaRaquel EgeaMichelle Morataya-ReyesMireia Cassú-CasadevallIrene BarguillaRicard MarcosAlba HernándezAlba García-Rodríguez https://www.frontiersin.org/articles/10.3389/ftox.2026.1740390 https://www.frontiersin.org/articles/10.3389/ftox.2026.1740390 <![CDATA[New approach methodologies (NAMs) to support regulatory assessment of developmental immunotoxicity – a new PARC project]]> 2026-04-17T00:00:00Z Review Nicola M. SmithVéronique M. P. de BruijnRob J. VandebrielRita HargitaiKatalin LumniczkyAafke W. F. JanssenKarsten BeekmannBirol UstaJulia TiggesChristiane SpruckSelma HuremMartina IuliniEmanuela CorsiniAnne Bado-NillesRémy BeaudouinIoanna KatsiadakiIrene CanoMarion SebireHumblenoble Stembridge AyukVioleta StojanovskaAna C. ZenclussenEtienne B. BlancSaadia Kerdine-RömerRafaela LacerdaLuísa RomãoPablo Monfort-LanzasJohanna M. GostnerArchibold MposhiJonathan D. TurnerGiorgia Del FaveroBirgitte Lindeman https://www.frontiersin.org/articles/10.3389/ftox.2026.1758512 https://www.frontiersin.org/articles/10.3389/ftox.2026.1758512 <![CDATA[From beauty to burden: mapping the health and psychosocial impacts of fragrances and cosmetic products use in the UAE]]> 2026-04-15T00:00:00Z Original Research Sharifa AlBlooshiMariam Al AliDana N. AbdelrahimSuheir Awadalla https://www.frontiersin.org/articles/10.3389/ftox.2026.1808944 https://www.frontiersin.org/articles/10.3389/ftox.2026.1808944 <![CDATA[Comparative evaluation of enzymatic, acidic, and alkaline digestion protocols for organic matrix removal from lyophilized and frozen mussel samples (Mytilus galloprovincialis)]]> 2026-04-15T00:00:00Z Original Research S. TurmanovaY. HristovD. KiryakovaE. IvanovaP. AtanasovaG. KolchakovaA. IlievaE. MollovaA. DimitrovN. TodorovG. Grigorova 96%). Acidic digestion provided rapid and stable removal of organic matter within 20 min, whereas enzymatic digestion required longer incubation times (2–24 h) but exerted the least impact on polymer integrity. Frozen samples consistently showed slightly higher digestion efficiencies compared to lyophilized ones, likely due to preserved tissue hydration facilitating reagent penetration. Microscopic and spectroscopic analyses revealed that HDPE and PET maintained their structural and chemical integrity under all treatments, whereas PA and PVC exhibited surface alterations after acidic digestion. Enzymatic and alkaline protocols did not produce visible or spectral changes in any polymer type. Based on these findings, the enzymatic protocol was selected for recovery experiments. Mass-corrected recovery values ranged from 92.87% to 95.36% for PA, PET, and PVC, and 75.69% for HDPE, indicating that the method allows effective isolation of most polymers while preserving their integrity. The results demonstrate that although all digestion methods are efficient in removing organic matter, enzymatic digestion provides the most reliable approach for microplastic analysis in Mytilus galloprovincialis, ensuring both high digestion efficiency and preservation of polymer characteristics.]]> https://www.frontiersin.org/articles/10.3389/ftox.2026.1773891 https://www.frontiersin.org/articles/10.3389/ftox.2026.1773891 <![CDATA[Organ-specific bioaccumulation and deterministic health risk assessment of selected heavy metal(loid)s in commercial fish from a southern harbor region (Nagapattinam)]]> 2026-04-10T00:00:00Z Original Research Suryapratap RayRahul Vashishth