Frontiers in Toxicology | Developmental and Reproductive Toxicology

Original Research

Published on 11 Feb 2026

Evaluating chemotherapy-driven placental alterations and their impact on fetal development

in Developmental and Reproductive Toxicology

Katrien De Clercq
Carolina Velazquez
Eleonora Persoons
Vera Wolters
Marieke Van de Ven
Frédéric Amant

Frontiers in Toxicology

doi 10.3389/ftox.2025.1688641

464 views

Mini Review

Published on 09 Feb 2026

From prioritization to implementation: updating the PARC WP5 project portfolio through the second prioritization round

in Developmental and Reproductive Toxicology

Celia Garcia Arenas
Kiara Aiello Holden
Terje Svingen
Dries Knapen
Saadia Kerdine-Römer
Birgitte Lindeman
Nicola M. Smith
Ludovic Le Hegarat
Tamara Vanhaecke
Gilles Rivière

Frontiers in Toxicology

doi 10.3389/ftox.2026.1746437

527 views

Review

Published on 03 Feb 2026

New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption – a PARC project

in Developmental and Reproductive Toxicology

Jacob Ardenkjær-Skinnerup
Yoni Baert
Lola Bajard
Jonathan Blum
François Brion
Lucia Coppola
Jean-Baptiste Fini
Ellen Fritsche
Henrik Holbech
Selma Hurem

Frontiers in Toxicology

doi 10.3389/ftox.2026.1736963

1,097 views

Original Research

Published on 15 Jan 2026

Testicular mitochondrial redox imbalance and impaired oxidative phosphorylation underlie microplastic-induced testicular dysfunction in Wistar rats

in Developmental and Reproductive Toxicology

Samuel Abiodun Kehinde
Tolulope Peter Fatokun
Sarva Mangala Praveena
Abosede Temitope Olajide
Chau Ling Tham
Mariana Teles Pereira
Sasitorn Chusri

Frontiers in Toxicology

doi 10.3389/ftox.2026.1699288

878 views

Review

Published on 12 Jan 2026

The zebrafish in toxicology: a bibliometric analysis reveals current trends and future avenues for predictive safety assessment

in Developmental and Reproductive Toxicology

Carla Lima
Darlan Gusso
Geonildo Rodrigo Disner
Felipe Justiniano Pinto
Maria Alice Pimentel Falcão
João Gabriel Santos Rosa
Mônica Lopes-Ferreira

Frontiers in Toxicology

doi 10.3389/ftox.2025.1700031

1,243 views

Original Research

Published on 08 Jan 2026

Short-chain PFAS exposure during gestation and breastfeeding alters learning and memory in adulthood: possible mechanisms related to brain development

in Developmental and Reproductive Toxicology

Luca Lorenzini
Marzia Moretti
Claudia Zanardello
Federica Gallocchio
Vito A. Baldassarro
Alessandra Moressa
Lorenzo Zanella
Michele Sannia
Greta Foiani
Corinne Quadalti

Frontiers in Toxicology

doi 10.3389/ftox.2025.1702330

1,092 views

Review

Published on 05 Jan 2026

Effects of atrazine on the HPG and HPA axes and steroidogenic pathways in females: relevance to reproductive function and breast, ovarian and uterine cancer

in Developmental and Reproductive Toxicology

Ralph L. Cooper
James W. Simpkins
Charles Breckenridge

Frontiers in Toxicology

doi 10.3389/ftox.2025.1686703

1,057 views
1 citation

Original Research

Published on 22 Dec 2025

Astragaloside IV ameliorates atrazine-induced male reproductive toxicity: an in vivo and in silico analysis

in Developmental and Reproductive Toxicology

Srinivasa Rao Sirasanagandla
Mohamed Al Mushaiqri
Firas Al-Majrafi
Nadia Al-Abri
Selvaraj Jayaraman
Isehaq Saif Al Huseini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1692518

1,157 views

Original Research

Published on 27 Nov 2025

Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project

in Developmental and Reproductive Toxicology

Hubert Dirven
Aleksandra Bogusz
Hans Bouwmeester
Mathias Busch
Guillaume Duflos
Gunnar S. Eriksen
Margarida Fardilha
Daniela Flores-Gomez
Nina Franko
Laurent Gaté

Frontiers in Toxicology

doi 10.3389/ftox.2025.1719035

2,385 views

Systematic Review

Published on 24 Nov 2025

Endocrine disruption rewards: bisphenol-A-induced reproductive toxicity and the precision ameliorative potential of flavonoids in preclinical studies. A systematic review and meta-analysis

in Developmental and Reproductive Toxicology

Michael Ben Okon
Ilemobayo Victor Fasongbon
Dominic Swase
Reuben Samson Dangana
Wusa Makena
Vivian Onyinye Ojiakor
Ekom Monday Etukudo
Joan Chebet
Angela Mumbua Musyoka
Sandra Etumah Ifie

Frontiers in Toxicology

doi 10.3389/ftox.2025.1687862

1,763 views

Original Research

Published on 24 Nov 2025

Cadmium and glyphosate jointly compromise sperm function, fertilization, and early development in Prochilodus magdalenae

in Developmental and Reproductive Toxicology

Jose Espinosa-Araujo
Lucellys Sierra-Marquez
Victor Atencio-Garcia
Jesus Olivero-Verbel

Frontiers in Toxicology

doi 10.3389/ftox.2025.1698489

1,083 views

Systematic Review

Published on 19 Nov 2025

Systematic literature review and meta-analysis on the reproductive effects of micro- pollutants in humans and animals

in Developmental and Reproductive Toxicology

Luca Coppeta
Cristiana Ferrari
Lorenzo Ippoliti
Luisa Campagnolo
Andrea Magrini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1671098

1,549 views

Review

Published on 03 Oct 2025

Pesticides, an urgent challenge to global environmental health and planetary boundaries

in Developmental and Reproductive Toxicology

Laura N. Vandenberg
Elise J. Pierce
Rachel M. Arsenault

Frontiers in Toxicology

doi 10.3389/ftox.2025.1656297

4,056 views
2 citations

Original Research

Published on 29 Sep 2025

In Vitro analysis of the effect of mono-(2-ethylhexyl) phthalate (MEHP) exposure on macrophage inflammatory responses in relationship to Leydig cell steroid production

in Developmental and Reproductive Toxicology

Akhil Adla
Allison Lunney
Barry Zirkin
Kassim Traore

Frontiers in Toxicology

doi 10.3389/ftox.2025.1636395

1,798 views

Original Research

Published on 25 Sep 2025

Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment

in Developmental and Reproductive Toxicology

José M. Horcas-Nieto
Sabine Hartvelt
Luke Flatt
Jing Fang
Esther Lam
Gaonan Zhang
Romy Van Vliet
Marleen Feliksik
Tom Zwetsloot
Connor Philippo

Frontiers in Toxicology

doi 10.3389/ftox.2025.1645842

2,964 views

Hypothesis and Theory

Published on 21 Aug 2025

Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study

in Developmental and Reproductive Toxicology

Melissa Badding
Noor Aly
Kevin Sondenheimer

Frontiers in Toxicology

doi 10.3389/ftox.2025.1639737

1,975 views

Original Research

Published on 30 Jun 2025

An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox

in Developmental and Reproductive Toxicology

Iris Mueller
Ashraf Abdelkhaliq
Paul Carmichael
Matthew Dent
Marleen Feliksik
Luke Flatt
Jade Houghton
José M. Horcas Nieto
Amer Jamalpoor
Predrag Kukic

Frontiers in Toxicology

doi 10.3389/ftox.2025.1602065

6,187 views
1 citation

Original Research

Published on 21 May 2025

Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina

in Developmental and Reproductive Toxicology

Florencia Doná
Virginia Lorenz
Georgina Stegmayer
Tamara Ricardo
Stefanía D’Iorio
Fernando Ponzo
María Rosa Repetti
Luisina Delma Demonte
María Mercedes Milesi
Jorgelina Varayoud

Frontiers in Toxicology

doi 10.3389/ftox.2025.1579952

3,763 views
1 citation

Original Research

Published on 08 May 2025

Rat embryonic stem cell-based in vitro testing platform for mammalian embryo toxicology at pre- and post-implantation stages

in Developmental and Reproductive Toxicology

Corinne Quadalti
Marzia Moretti
Fabio Ferrazzi
Laura Calzà
Luciana Giardino
Vito Antonio Baldassarro

Frontiers in Toxicology

doi 10.3389/ftox.2025.1561386

2,810 views

Perspective

Published on 13 Mar 2025

Pesticides and public health: discussing risks in Brazilian agro-industrial growth

in Developmental and Reproductive Toxicology

Juliana E. Perobelli

Frontiers in Toxicology

doi 10.3389/ftox.2025.1442801

9,653 views
6 citations

Review

Published on 26 Feb 2025

Comprehensive overview of the toxicities of small-molecule cryoprotectants for carnivorous spermatozoa: foundation for computational cryobiotechnology

in Developmental and Reproductive Toxicology

Isaac Karimi
Layth Jasim Mohammad
A. Suvitha
Zohreh Haidari
Helgi B. Schiöth

Frontiers in Toxicology

doi 10.3389/ftox.2025.1477822

3,551 views
3 citations

Systematic Review

Published on 17 Oct 2024

A systematic review and meta-analysis of the impact of triclosan exposure on human semen quality

in Developmental and Reproductive Toxicology

Cecilia Adedeji Adegbola
Tunmise Maryanne Akhigbe
Adetomiwa Ezekiel Adeogun
Eva Tvrdá
Alica Pizent
Roland Eghoghosoa Akhigbe

Frontiers in Toxicology

doi 10.3389/ftox.2024.1469340

3,504 views
9 citations

Perspective

Published on 11 Oct 2024

Reproductive toxicology: keeping up with our changing world

in Developmental and Reproductive Toxicology

Laura B. Miller
Morgan B. Feuz
Ralph G. Meyer
Mirella L. Meyer-Ficca

Frontiers in Toxicology

doi 10.3389/ftox.2024.1456687

7,125 views
1 citation

Original Research

Published on 01 Oct 2024

Assessment of the effects of cannabidiol and a CBD-rich hemp extract in Caenorhabditis elegans

in Developmental and Reproductive Toxicology

Jessica A. Camacho
Bonnie Welch
Martine Ferguson
Estatira Sepehr
Cory Vaught
Yang Zhao
Suzanne Fitzpatrick
Jeffrey Yourick
Robert L. Sprando
Piper Reid Hunt

Frontiers in Toxicology

doi 10.3389/ftox.2024.1469341

14,782 views
1 citation

90 articles

articles

Evaluating chemotherapy-driven placental alterations and their impact on fetal development

From prioritization to implementation: updating the PARC WP5 project portfolio through the second prioritization round

New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption – a PARC project

Testicular mitochondrial redox imbalance and impaired oxidative phosphorylation underlie microplastic-induced testicular dysfunction in Wistar rats

The zebrafish in toxicology: a bibliometric analysis reveals current trends and future avenues for predictive safety assessment

Short-chain PFAS exposure during gestation and breastfeeding alters learning and memory in adulthood: possible mechanisms related to brain development

Effects of atrazine on the HPG and HPA axes and steroidogenic pathways in females: relevance to reproductive function and breast, ovarian and uterine cancer

Astragaloside IV ameliorates atrazine-induced male reproductive toxicity: an in vivo and in silico analysis

Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project

Endocrine disruption rewards: bisphenol-A-induced reproductive toxicity and the precision ameliorative potential of flavonoids in preclinical studies. A systematic review and meta-analysis

Cadmium and glyphosate jointly compromise sperm function, fertilization, and early development in Prochilodus magdalenae

Systematic literature review and meta-analysis on the reproductive effects of micro- pollutants in humans and animals

Pesticides, an urgent challenge to global environmental health and planetary boundaries

In Vitro analysis of the effect of mono-(2-ethylhexyl) phthalate (MEHP) exposure on macrophage inflammatory responses in relationship to Leydig cell steroid production

Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment

Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study

An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox

Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina

Rat embryonic stem cell-based in vitro testing platform for mammalian embryo toxicology at pre- and post-implantation stages

Pesticides and public health: discussing risks in Brazilian agro-industrial growth

Comprehensive overview of the toxicities of small-molecule cryoprotectants for carnivorous spermatozoa: foundation for computational cryobiotechnology

A systematic review and meta-analysis of the impact of triclosan exposure on human semen quality

Reproductive toxicology: keeping up with our changing world

Assessment of the effects of cannabidiol and a CBD-rich hemp extract in Caenorhabditis elegans