Frontiers in Toxicology | In Vitro Toxicology

Original Research

Accepted on 28 Mar 2025

Quantitative adverse outcome pathway modeling for cigarette smoke-inducible airway mucus hypersecretion. Part 1: AOP-based in vitro assessment with repeated exposure to whole cigarette smoke Authors

in In Vitro Toxicology

Sakuya Ichikawa
Shugo Muratani
Keigo Sano
Kazuo Erami
Akina Mori
Risa Matsumoto
Shigeaki Ito

Frontiers in Toxicology

doi 10.3389/ftox.2025.1564857

165 views

Original Research

Published on 26 Mar 2025

Advancing humanized 3D tumor modeling using an open access xeno-free medium

in In Vitro Toxicology

Atena Malakpour-Permlid
Manuel Marcos Rodriguez
Kinga Zór
Anja Boisen
Stina Oredsson

Frontiers in Toxicology

doi 10.3389/ftox.2025.1529360

1,043 views

Original Research

Published on 21 Feb 2025

Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety

in In Vitro Toxicology

Renato Ivan de Ávila
Iris Müller
Hugh Barlow
Alistair Mark Middleton
Mathura Theiventhran
Danilo Basili
Anthony M. Bowden
Ouarda Saib
Patrik Engi
Tymoteusz Pietrenko

Frontiers in Toxicology

doi 10.3389/ftox.2025.1426132

2,755 views

Original Research

Published on 21 Feb 2025

Evaluation of estrogenic and anti-estrogenic activity of endocrine disruptors using breast cancer spheroids: a comparative study of T47D and MCF7 cell lines in 2D and 3D models

in In Vitro Toxicology

Katia Barbaro
Elisa Innocenzi
Valentina Monteleone
Daniele Marcoccia
Annalisa Altigeri
Alessia Zepparoni
Daniela Caciolo
Cristian Alimonti
Marta Mollari
Paola Ghisellini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1547640

942 views

Editorial

Published on 12 Feb 2025

Editorial: Leveraging artificial intelligence and open science for toxicological risk assessment

in In Vitro Toxicology

Marc Teunis
Thomas Luechtefeld
Thomas Hartung

Frontiers in Toxicology

doi 10.3389/ftox.2025.1568453

1,035 views

Original Research

Published on 12 Feb 2025

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening

in In Vitro Toxicology

Tasnia Sharin
Doug Crump
Jason M. O’Brien

Frontiers in Toxicology

doi 10.3389/ftox.2025.1482865

588 views

Original Research

Published on 28 Nov 2024

In vitro toxicological evaluation of pouched portioned oral nicotine products

in In Vitro Toxicology

Brian M. Keyser
Robert Leverette
Reagan McRae
John Wertman
Tom Shutsky
Ken Szeliga
Patrudu Makena
Kristen G. Jordan

Frontiers in Toxicology

doi 10.3389/ftox.2024.1452274

1,810 views
1 citation

Review

Published on 26 Nov 2024

AI and ML-based risk assessment of chemicals: predicting carcinogenic risk from chemical-induced genomic instability

in In Vitro Toxicology

Ajay Vikram Singh
Preeti Bhardwaj
Peter Laux
Prachi Pradeep
Madleen Busse
Andreas Luch
Akihiko Hirose
Christopher J. Osgood
Michael W. Stacey

Frontiers in Toxicology

doi 10.3389/ftox.2024.1461587

3,884 views
13 citations

Original Research

Published on 22 Nov 2024

Increasing sustainability and reproducibility of in vitro toxicology applications: serum-free cultivation of HepG2 cells

in In Vitro Toxicology

Luisa Marie Pfeifer
Janike Sensbach
Frederic Pipp
Daniela Werkmann
Philip Hewitt

Frontiers in Toxicology

doi 10.3389/ftox.2024.1439031

1,948 views

Original Research

Published on 06 Nov 2024

A multimodal in vitro approach to assess the safety of oral care products using 2D and 3D cellular models

in In Vitro Toxicology

S. Marceli Leano
Wanderson De Souza
Rodrigo De Vecchi
Amanda Lopes
Tatiana Deliberador
Jose M. Granjeiro

Frontiers in Toxicology

doi 10.3389/ftox.2024.1474583

1,477 views

Original Research

Published on 05 Nov 2024

Use of serum-free media for peripheral blood mononuclear cell culture and the impact on T and B cell readouts

in In Vitro Toxicology

Stella Cochrane
Ouarda Saib
David Sheffield

Frontiers in Toxicology

doi 10.3389/ftox.2024.1462688

2,745 views

Original Research

Published on 24 Oct 2024

Assessment of pulmonary fibrosis using weighted gene co-expression network analysis

in In Vitro Toxicology

Christina Drake
Walter Zobl
Sylvia E. Escher

Frontiers in Toxicology

doi 10.3389/ftox.2024.1465704

816 views

Review

Published on 08 Oct 2024

New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report

in In Vitro Toxicology

Lynne T. Haber
Mark A. Bradley
Amanda N. Buerger
Holger Behrsing
Sabina Burla
Phillip W. Clapp
Scott Dotson
Casey Fisher
Keith R. Genco
Francis H. Kruszewski

Frontiers in Toxicology

doi 10.3389/ftox.2024.1431790

3,761 views

Original Research

Published on 05 Sep 2024

Inhibitory effects of NaF on mitochondrial energy generation in human platelets in vitro

in In Vitro Toxicology

Tetsuhiro Tsujino
Tomoni Kasahara
Hideo Kawabata
Taisuke Watanabe
Koji Nishiyama
Yutaka Kitamura
Takao Watanabe
Hajime Okudera
Tomoharu Mochizuki
Takashi Ushiki

Frontiers in Toxicology

doi 10.3389/ftox.2024.1421184

1,611 views
1 citation

Original Research

Published on 25 Jul 2024

Diesel exhaust particles alter mitochondrial bioenergetics and cAMP producing capacity in human bronchial epithelial cells

in In Vitro Toxicology

Isabella Cattani-Cavalieri
Marina Trombetta-Lima
Hong Yan
Ana L. Manzano-Covarrubias
Hoeke A. Baarsma
Asmaa Oun
Melissa Mol van der Veen
Emily Oosterhout
Amalia M. Dolga
Rennolds S. Ostrom

Frontiers in Toxicology

doi 10.3389/ftox.2024.1412864

2,177 views
4 citations

Original Research

Published on 23 Jul 2024

An insight into carcinogenic activity and molecular mechanisms of Bis(2-ethylhexyl) phthalate

in In Vitro Toxicology

Gelsomina Pillo
Federico Aldrovandi
Ada Mescoli
Giangabriele Maffei
Maria Grazia Mascolo
Monica Vaccari
Annamaria Colacci

Frontiers in Toxicology

doi 10.3389/ftox.2024.1389160

3,117 views