Frontiers in Toxicology | In Vitro Toxicology

Original Research

Accepted on 08 Jul 2025

Cadmium Decreases Human Gingival Fibroblast Viability and Induces Pro-Inflammatory Response Associated with Akt and MAPK Pathway Activation

in In Vitro Toxicology

Tipparat Parakaw
Sirada Srihirun
Nathawut Sibmooh
Nisarat Ruangsawasdi
Phisit Khemawoot
Pornpun Vivithanaporn

Frontiers in Toxicology

doi 10.3389/ftox.2025.1583865

113 views

Original Research

Published on 01 Jul 2025

Toxicity of glyphosate accelerates neurodegeneration in Caenorhabditis elegans model of Alzheimer’s disease

in In Vitro Toxicology

Nisha Rani
Mohammad Mumtaz Alam
Suhel Parvez

Frontiers in Toxicology

doi 10.3389/ftox.2025.1578230

605 views

Review

Published on 30 Jun 2025

An adverse outcome pathway for cigarette smoke-mediated oxidative stress in plaque formation

in In Vitro Toxicology

Patrudu Makena
Linsey E. Haswell
Michael McEwan
Brian M. Keyser
David E. Smart
Robert Leverette
Kristen Jordan
Damien Breheny
Sarah Baxter-Wright

Frontiers in Toxicology

doi 10.3389/ftox.2025.1554747

757 views

Systematic Review

Published on 27 Jun 2025

Towards the standardization of human platelet lysate production and its comparison to fetal bovine serum for human hematopoietic cell culture: a scoping review

in In Vitro Toxicology

Shamili Immalaraju
Srishti Goyal
Rukmini Jonnalagadda

Frontiers in Toxicology

doi 10.3389/ftox.2025.1496231

546 views

Original Research

Published on 23 Jun 2025

An injectable 2.5% cross-linked polyacrylamide hydrogel (2.5 iPAAG) demonstrates no neurotoxicity in human induced pluripotent stem cells-derived iCell® GlutaNeurons

in In Vitro Toxicology

Peter S. Walmod
Philip Kusk
Nina Jøhnk
Ieva Ankorina-Stark
Anthony Essex

Frontiers in Toxicology

doi 10.3389/ftox.2025.1585430

884 views

Review

Accepted on 12 Jun 2025

Fetal bovine serum: How to leave it behind in the pursuit of more reliable science

in In Vitro Toxicology

Tilo Weber
Atena Malakpour Permlid
Aline Chary
Vito D'Alessandro
Leah Haut
Sebastian Seufert
Esther Veronika Wenzel
James Hickman
Karen Bieback
Joachim Wiest

Frontiers in Toxicology

doi 10.3389/ftox.2025.1612903

507 views

Original Research

Published on 12 Jun 2025

Bioengineering of novel organotypic 3D human liver tissue model for drug-induced liver injury and toxicity studies

in In Vitro Toxicology

Camden Holm
Joseph Finelli
Mateo Frare
Alex Armento
Seyoum Ayehunie

Frontiers in Toxicology

doi 10.3389/ftox.2025.1574387

1,279 views

Original Research

Published on 15 May 2025

Quantitative adverse outcome pathway modeling for cigarette-smoke-induced airway mucus hypersecretion. Part 1: adverse-outcome-pathway-based in vitro assessment with repeated exposure to whole cigarette smoke

in In Vitro Toxicology

Sakuya Ichikawa
Shugo Muratani
Keigo Sano
Kazuo Erami
Akina Mori
Risa Matsumoto
Shigeaki Ito

Frontiers in Toxicology

doi 10.3389/ftox.2025.1564857

1,092 views

Original Research

Published on 26 Mar 2025

Advancing humanized 3D tumor modeling using an open access xeno-free medium

in In Vitro Toxicology

Atena Malakpour-Permlid
Manuel Marcos Rodriguez
Kinga Zór
Anja Boisen
Stina Oredsson

Frontiers in Toxicology

doi 10.3389/ftox.2025.1529360

1,714 views

Original Research

Published on 21 Feb 2025

Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety

in In Vitro Toxicology

Renato Ivan de Ávila
Iris Müller
Hugh Barlow
Alistair Mark Middleton
Mathura Theiventhran
Danilo Basili
Anthony M. Bowden
Ouarda Saib
Patrik Engi
Tymoteusz Pietrenko

Frontiers in Toxicology

doi 10.3389/ftox.2025.1426132

3,533 views

Original Research

Published on 21 Feb 2025

Evaluation of estrogenic and anti-estrogenic activity of endocrine disruptors using breast cancer spheroids: a comparative study of T47D and MCF7 cell lines in 2D and 3D models

in In Vitro Toxicology

Katia Barbaro
Elisa Innocenzi
Valentina Monteleone
Daniele Marcoccia
Annalisa Altigeri
Alessia Zepparoni
Daniela Caciolo
Cristian Alimonti
Marta Mollari
Paola Ghisellini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1547640

1,668 views

Original Research

Published on 12 Feb 2025

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening

in In Vitro Toxicology

Tasnia Sharin
Doug Crump
Jason M. O’Brien

Frontiers in Toxicology

doi 10.3389/ftox.2025.1482865

875 views

Editorial

Published on 12 Feb 2025

Editorial: Leveraging artificial intelligence and open science for toxicological risk assessment

in In Vitro Toxicology

Marc Teunis
Thomas Luechtefeld
Thomas Hartung

Frontiers in Toxicology

doi 10.3389/ftox.2025.1568453

1,552 views
1 citation

Original Research

Published on 28 Nov 2024

In vitro toxicological evaluation of pouched portioned oral nicotine products

in In Vitro Toxicology

Brian M. Keyser
Robert Leverette
Reagan McRae
John Wertman
Tom Shutsky
Ken Szeliga
Patrudu Makena
Kristen G. Jordan

Frontiers in Toxicology

doi 10.3389/ftox.2024.1452274

2,613 views
1 citation

Review

Published on 26 Nov 2024

AI and ML-based risk assessment of chemicals: predicting carcinogenic risk from chemical-induced genomic instability

in In Vitro Toxicology

Ajay Vikram Singh
Preeti Bhardwaj
Peter Laux
Prachi Pradeep
Madleen Busse
Andreas Luch
Akihiko Hirose
Christopher J. Osgood
Michael W. Stacey

Frontiers in Toxicology

doi 10.3389/ftox.2024.1461587

5,474 views
19 citations

Original Research

Published on 22 Nov 2024

Increasing sustainability and reproducibility of in vitro toxicology applications: serum-free cultivation of HepG2 cells

in In Vitro Toxicology

Luisa Marie Pfeifer
Janike Sensbach
Frederic Pipp
Daniela Werkmann
Philip Hewitt

Frontiers in Toxicology

doi 10.3389/ftox.2024.1439031

2,747 views
1 citation