Frontiers in Toxicology | Regulatory Toxicology

Original Research

Published on 05 Nov 2025

Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds

in Regulatory Toxicology

R. R. Sillito
J. Sutherland
A. Milne
C. Giuliano
C. Sigfridsson
M. Rolf
A. K. Cherian
M. McClafferty
E. I. Rossman
G. Teuns

Frontiers in Toxicology

doi 10.3389/ftox.2025.1655330

689 views

Original Research

Published on 08 Oct 2025

Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework

in Regulatory Toxicology

Jessica Ryman
Richard A. Becker

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657708

1,324 views

Original Research

Published on 15 Sep 2025

Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology

in Regulatory Toxicology

A. Rasim Barutcu
Nimisha Bhattarai
Raymond Samuel
Jamie Scaglione
Leslie Recio

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657189

1,262 views

Original Research

Published on 11 Aug 2025

Assessment of heated herbal products’ tobacco harm reduction potential: pre‐clinical and clinical studies

in Regulatory Toxicology

Alvaro-Flavio Marinas-Lacasta
Ian M. Fearon
Matthew Stevenson
Tasnim Abusalem
Fiona Chapman
Edgar Trelles Sticken
Roman Wieczorek
Sarah Jean Pour
Ole Dethloff
Ourania Komini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1589480

3,204 views

Original Research

Published on 04 Aug 2025

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies

in Regulatory Toxicology

Annick D. van den Brand
Julia J. Meerman
Christina H. J. Veltman
Mirjam Luijten

Frontiers in Toxicology

doi 10.3389/ftox.2025.1616817

1,365 views

Perspective

Published on 17 Jul 2025

Stress convulsions in rodents: within a weight-of-evidence framework for human seizure risk

in Regulatory Toxicology

Joseph J. DeGeorge
Monica R. Metea

Frontiers in Toxicology

doi 10.3389/ftox.2025.1600816

1,210 views

Original Research

Published on 04 Jun 2025

Characterization of medical device constituents and development of duration-based non-cancer threshold of toxicological concern values

in Regulatory Toxicology

Taylor Builee
Todd A. Kennedy
Valériane Levelut
Megan A. Hahn
Stephen Bond
Michael K. Peterson
Frances K. Hsia
Alessia Stornetta
Kristin J. Erickson
Kimberly D. Ehman

Frontiers in Toxicology

doi 10.3389/ftox.2025.1600127

5,672 views

Mini Review

Published on 14 May 2025

Optimizing Wnt activation in fetal calf serum (FCS)-free organoid expansion media

in Regulatory Toxicology

Esther J. M. Liefting
Jeffrey J. Bajramovic

Frontiers in Toxicology

doi 10.3389/ftox.2025.1504469

2,086 views
1 citation

Original Research

Published on 14 Mar 2025

Selection of the critical effect size alters hazard characterization – a retrospective analysis of key studies used for risk assessments of PFAS

in Regulatory Toxicology

L. Brunken
A. Vieira Silva
M. Öberg

Frontiers in Toxicology

doi 10.3389/ftox.2025.1525089

2,097 views

Perspective

Published on 15 Jan 2025

Young TPI: empowering animal-free science among the next- generation of scientists

in Regulatory Toxicology

Marta G. Valverde
Fatima Zohra Abarkan
Rebecca Van Eijden
Julia M. L. Menon
Nikolas Gaio
Aarti Ramchandran
Victoria C. De Leeuw

Frontiers in Toxicology

doi 10.3389/ftox.2024.1521317

8,432 views

Editorial

Published on 10 Jan 2025

Editorial: Emerging topics on chemical safety assessment

in Regulatory Toxicology

Maricel V. Maffini
Laura N. Vandenberg

Frontiers in Toxicology

doi 10.3389/ftox.2024.1542469

2,097 views
1 citation

Editorial

Published on 18 Dec 2024

Editorial: Reducing animal use in carcinogenicity testing

in Regulatory Toxicology

Jan Willem Van der Laan
Joseph Manuppello

Frontiers in Toxicology

doi 10.3389/ftox.2024.1538905

1,171 views

Perspective

Published on 06 Dec 2024

Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip

in Regulatory Toxicology

Huub J. Weener
Heleen H. T. Middelkamp
Andries D. Van der Meer

Frontiers in Toxicology

doi 10.3389/ftox.2024.1513002

2,310 views
1 citation

Original Research

Published on 01 Nov 2024

Identifying non-essential uses to phase out substances of very high concern under REACH

in Regulatory Toxicology

Flora Borchert
Romain Figuière
Ian T. Cousins
Christina Rudén
Marlene Ågerstrand

Frontiers in Toxicology

doi 10.3389/ftox.2024.1488336

3,874 views

Original Research

Published on 03 Oct 2024

Fulfilling the criteria for CLP classification: the implications for substances under the EU chemicals legislation

in Regulatory Toxicology

Diana Kättström
Anna Beronius
Urban Boije af Gennäs
Christina Rudén
Marlene Ågerstrand

Frontiers in Toxicology

doi 10.3389/ftox.2024.1452065

3,447 views
1 citation

Brief Research Report

Published on 02 Oct 2024

Neonicotinoid pesticides: evidence of developmental neurotoxicity from regulatory rodent studies

in Regulatory Toxicology

Jennifer Beth Sass
Nathan Donley
William Freese

Frontiers in Toxicology

doi 10.3389/ftox.2024.1438890

10,390 views
5 citations