AUTHOR=Anderson Douglas J. , Locke Jayme E. 

TITLE=Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate models

JOURNAL=Frontiers in Transplantation

VOLUME=Volume 4 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2025.1576549

DOI=10.3389/frtra.2025.1576549

ISSN=2813-2440

ABSTRACT=Non-human primates and decedent humans have emerged as the two principal translational models in xenotransplantation. Each model has differing advantages and drawbacks. In this manuscript, we will compare and contrast the relative strengths of each model, focusing on the physiologic function of the xenograft in a human decedent or non-human primate. Additionally, we will discuss the pharmacologic agents typically employed in each model, highlighting both the ability of the decedent model to test clinically-relevant medication strategies that may be impossible in non-human primates due to species-specificity.