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        <title>Frontiers in Transplantation | Bioengineering section | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/transplantation/sections/bioengineering</link>
        <description>RSS Feed for Bioengineering section in the Frontiers in Transplantation journal | New and Recent Articles</description>
        <language>en-us</language>
        <generator>Frontiers Feed Generator,version:1</generator>
        <pubDate>2026-05-12T08:16:03.366+00:00</pubDate>
        <ttl>60</ttl>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frtra.2025.1676566</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frtra.2025.1676566</link>
        <title><![CDATA[Case Report: Lessons learned from large animal implantation of an all-natural tissue engineered vascular graft]]></title>
        <pubdate>2025-10-07T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Alexandru I. Dumitru</author><author>Bryan T. Wonski</author><author>Renée A. Cole</author><author>Mitchell R. Weaver</author><author>Kelsey C. Carpenter</author><author>Loay S. Kabbani</author><author>Mai T. Lam</author>
        <description><![CDATA[Cardiovascular disease continues to be the number one cause of morbidity and mortality across the world. Coronary artery bypass graft (CABG) procedures are the most commonly performed major surgery in the U.S. Grafts are difficult to source as patients do not have many sites from which to harvest donor tissues as autografts. Plastic grafts have issues of infection and are only used as a last resort. Tissue engineered vascular grafts have potential to solve the need for all-natural vascular grafts in the clinic. In this study, we evaluate the feasibility of a completely biological engineered vascular graft for implantation in a large animal model of a rabbit. An all-biological tissue engineered graft was grown in our laboratory, composed of a tunica adventitia derived from human dermal fibroblasts and a tunica media made from human aortic smooth muscle cells. The all-biological engineered graft exhibited the “look and feel” of a natural vessel. The engineered graft was implanted into the abdominal aorta of a New Zealand rabbit. The graft easily anastomosed to the native abdominal aorta and showed no leakages. Once reperfused, the graft was able to withstand blood flow briefly, prior to exhibiting dissection between the media and adventitia. Color doppler ultrasound showed flow through the abdominal aorta, however, not through the graft region due to the dissected layers creating a blockage. These results support a shift from the traditional paradigm of designing vascular grafts to mimic the multi-layered native structure. The two-layer engineered graft tested here exhibited dissection between the layers, a phenomenon that has yet to be reported in the field to our knowledge. Based on these findings, we recommend a single layer engineered graft to best prevent dissection.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frtra.2025.1528548</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frtra.2025.1528548</link>
        <title><![CDATA[Research on the evaluation system of prosthesis structure type implanted with porous structure]]></title>
        <pubdate>2025-05-22T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Ye Zhu</author><author>Yong Jiang</author><author>Lei Lei</author><author>Hongchi Liu</author><author>Tianmin Guan</author>
        <description><![CDATA[The porous structure can effectively reduce the stress shielding effect in the process of implanting prostheses in the treatment of bone defects, but the performance of different types of porous structures directly affects the treatment effect, so it is necessary to evaluate a variety of different porous structures and select the most suitable structure type for implantation to improve the treatment effect. Based on the three-dimensional model of porous structure, this paper uses numerical analysis to evaluate the mechanical properties of porous structure and completes the primary selection of porous structure; secondly, the indexes and weights affecting the performance of porous structure are clarified, the calculation method of evaluation value is determined, and the evaluation system of implanted prosthesis with porous structure is constructed; then, through mechanical experiments and animal experiments, the machinability index and bone ingrowth index of the primary structure and commonly used clinical structure are studied; finally, according to the evaluation system, the most suitable type of porous structure for implantation is selected. The results of this study found that the tetrahedral body-centered structure [diamond structure] is the optimal structure type for the preparation of implanted prostheses with porous structures. The implantation of tetrahedral body-heart structure is of great significance for the treatment of segmental bone defects and can improve the quality of life of patients.]]></description>
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