AUTHOR=Di Gianfrancesco Luca , Crestani Alessandro , Amodeo Antonio , Corsi Paolo , De Marchi Davide , Miglioranza Eugenio , Lista Giuliana , Vitelli Ferdinando Daniele , Simonetti Francesca , Busetto Gian Maria , Falagario Ugo Giovanni , Maggi Martina , Marino Filippo , Genovese Giannicola , Falabella Roberto , Porreca Angelo 

TITLE=Lights and shadows on local recurrence after renal surgery: when, why and how to manage

JOURNAL=Frontiers in Urology

VOLUME=Volume 4 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/urology/articles/10.3389/fruro.2024.1419418

DOI=10.3389/fruro.2024.1419418

ISSN=2673-9828

ABSTRACT=IntroductionThis review aims to analyze the existing literature on local recurrence (LR) in patients undergoing partial nephrectomy (PN) for renal cell carcinoma, identifying relative risk factors, and exploring optimal clinical management strategies.MethodsA comprehensive literature search was conducted across bibliographic databases, primarily focusing on LR rates. Secondary outcomes included evaluation of positive surgical margins (PSM), nephrometry scores, pathological stage (T and grading), perioperative outcomes, time-to-LR, overall survival, and cancer-specific survival.ResultsDue to the heterogeneity, a narrative synthesis was performed. LR rates after PN varied in the literature; with PSM emerging as a significant risk factor. Other LR risk factors included pathological stage, nephrometry scores, and histological variants. However, evidence regarding optimal LR management in the absence of precise indications was lacking.ConclusionLR represents a significant clinical challenge; requiring multidisciplinary assessment and shared decision-making with patients. Given well-established risk factors, clinicians must tailor management strategies to optimize patient outcomes.