AUTHOR=Sobrino Odón J. , Alba Claudio , Arroyo Rebeca , Pérez Inés , Sariego Lydia , Delgado Susana , Fernández Leónides , de María Julián , Fumanal Pilar , Fumanal Antonio , Rodríguez Juan M. 

TITLE=Replacement of Metaphylactic Antimicrobial Therapy by Oral Administration of Ligilactobacillus salivarius MP100 in a Pig Farm

JOURNAL=Frontiers in Veterinary Science

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2021.666887

DOI=10.3389/fvets.2021.666887

ISSN=2297-1769

ABSTRACT=Antibiotic use in swine production contributes to the emergence and spread of resistant bacteria, which poses a threat on human health. Therefore, alternative approaches must be developed. The objective of this work was the characterization of the probiotic properties of a Ligilactobacillus salivarius strain isolated from sow’s milk and its application as an inoculated fermented feed to pregnant sows and piglets. The study was carried in a farm in which metaphylactic use of antimicrobials (including zinc oxide) was eliminated at the time of starting the probiotic intervention, which lasted for 2 years. Feces from 8-week-old piglets were collected before and after the treatment and microbiological and biochemical analyses were performed. The procedure led to an increase in the concentrations of clostridia and lactobacilli-related bacteria. Parallel, an increase in the concentration of butyrate, propionate and acetate was observed and a notable reduction in the presence of antibiotic resistant lactobacilli became apparent. This strategy resulted in the improvement of all productivity parameters tested (mortality rates at weaning and fattening, total fattening days, daily weight increase and number of live born piglets per sow. In conclusion, replacement of antimicrobials by a microbiota-friendly approach was feasible and provided Public Health and economic benefits.