AUTHOR=Chen Xueyang , Wang Xingming , Yang Yuxin , Fang Chun , Liu Jing , Liang Xiongyan , Yang Yuying 

TITLE=Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection

JOURNAL=Frontiers in Veterinary Science

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2022.1031480

DOI=10.3389/fvets.2022.1031480

ISSN=2297-1769

ABSTRACT=Avian leukemia virus subgroup A (ALV-A) infection slows chicken growth, immunosuppression, and tumor occurrence, causing economic losses to the poultry industry. According to previous findings, A20 has a dual role in promoting and inhibiting tumor formation but has rarely been studied in avians. In this study, A20 overexpression and shRNA interference recombinant adenoviruses were constructed and inoculated into chicken embryos, and ALV-A (rHB2015012) was inoculated into one-day-old chicks. The results of an analysis of body weight, organ index, detoxification, antibody production, and organ toxin load revealed that A20 overexpression could enhance the ALV-A pathogenicity. This study lays the foundation for the subsequent exploration of the A20-mediated tumorigenic mechanism of ALV-A.