AUTHOR=Corbee Ronald J. , van Everdingen Dion L. , Kooistra Hans S. , Penning Louis C. 

TITLE=Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients

JOURNAL=Frontiers in Veterinary Science

VOLUME=Volume 9 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2022.1086987

DOI=10.3389/fvets.2022.1086987

ISSN=2297-1769

ABSTRACT=Fibroblast growth factors (FGFs) are involved in numerous metabolic processes. The endocrine subfamily of FGFs, consisting of FGF19, FGF21, and FGF23, might have beneficial effects in the treatment of diabetes mellitus (DM) and/or obesity. The analogue with the greatest potential, FGF21, lowers blood glucose levels, improves insulin sensitivity, and induces weight loss in several animal models. In this review we summarize recent (pre)clinical findings with FGF21analogues in animal models and men. Furthermore, possible applications of FGF21 analogues for cats with DM will be discussed.