AUTHOR=Flores-Velázquez Luis Miguel , Ruiz-Campillo María Teresa , Herrera-Torres Guillem , Martínez-Moreno Álvaro , Martínez-Moreno Francisco Javier , Zafra Rafael , Buffoni Leandro , Rufino-Moya Pablo José , Molina-Hernández Verónica , Pérez José 

TITLE=Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development

JOURNAL=Frontiers in Veterinary Science

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2023.1270064

DOI=10.3389/fvets.2023.1270064

ISSN=2297-1769

ABSTRACT=Fasciola hepatica has a worldwide distribution causing important economic losses in animal production industry. Human fasciolosis is considered an emerging zoonosis in areas of Andean America, Asia, and Africa. The control of the disease both in humans and animals is based in the use of anthelmintic drugs which has induced increased resistance to most effective anthelmintics such as triclabendazole in many countries. This together with the concerns of drugs residues on food and environment has increased the interest for preventive measures such as a vaccine to help controlling the disease in endemic areas. Despite important efforts during the last two decades and the work carried out with numerous vaccine candidates, none of them has demonstrated consistent and reproducible protection in target species. This is at least in part due to the high immunomodulation capacity of the parasite making ineffective the host response in susceptible species such as ruminants. It is widely accepted that a deeper knowledge of the host-parasite interactions is needed for a more rationale design of vaccine candidates. In recent years the use of emerging technologies has notably increased the amount of data about these interactions. In the present revision current knowledge of host parasiteinteractions and their implication in Fasciola hepatica vaccine development is reviewed.