AUTHOR=Huang Jiajin , Ruan Yong , Xiao Meimei , Dai Lingang , Jiang Chuanmei , Li Jifeng , Xu Jiali , Chen Xiang , Xu Houqiang 

TITLE=Association between polymorphisms in NOBOX and litter size traits in Xiangsu pigs

JOURNAL=Frontiers in Veterinary Science

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1359312

DOI=10.3389/fvets.2024.1359312

ISSN=2297-1769

ABSTRACT=The newborn ovary homeobox gene (NOBOX) regulates ovarian and early oocyte development, and thus plays an essential role in reproduction. In this study, the mRNA expression level and single nucleotide polymorphism (SNP) of NOBOX in various tissues of Xiangsu pigs were studied to explore the relationship between its polymorphism and litter size traits. Also, bioinformatics was used to evaluate the effects of missense substitutions on protein structure and function. The results revealed that NOBOX is preferentially expressed in the ovary. Six mutations were detected in the NOBOX sequence, including g.1624 T>C,