AUTHOR=Liu Zhichen , Qin Qing , Zhang Chongyan , Xu Xiaolong , Dai Dongliang , Lan Mingxi , Wang Yichuan , Zhang Jingwen , Zhao Dan , Kong Deqing , Qin Tian , Wu Danni , Gong Xuedan , Zhou Xingyu , Suhe Alatan , Wang Zhixin , Liu Zhihong 

TITLE=Effects of nonsynonymous single nucleotide polymorphisms of the KIAA1217, SNTA1 and LTBP1 genes on the growth traits of Ujumqin sheep

JOURNAL=Frontiers in Veterinary Science

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1382897

DOI=10.3389/fvets.2024.1382897

ISSN=2297-1769

ABSTRACT=Sheep body size can directly reflect the growth rates and fattening rates of sheep and is also an important index for measuring the growth performance of meat sheep. In this study, high-resolution resequencing data from four sheep breeds (Dorper sheep, Suffolk sheep, Ouessant sheep, and Shetland sheep) were analyzed. Three candidate genes (KIAA1217, SNTA1, and LTBP1) related to body size were identified. To investigate the effects of nonsynonymous single nucleotide polymorphisms (nsSNPs) of the three genes on growth traits such as body length and chest depth in Ujumqin sheep, 24 nsSNP polymorphisms in these 3 genes were identified in 642 healthy Ujumqin sheep by MALDI-TOF-MS, and the genotyping results were associated with growth traits. The results showed that different genotypes of the KIAA1217 g.24429511T>C locus had significant effects on the chest circumferences of Ujumqin sheep. The SNTA1 g.62222626C>A locus had different effects on the chest depths, shoulder widths and rump widths of Ujumqin sheep. This study showed that these two sites can be used for marker-assisted selection, which will be beneficial for future precision molecular breeding.