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CASE REPORT article
Front. Vet. Sci.
Sec. Veterinary Experimental and Diagnostic Pathology
Volume 11 - 2024 |
doi: 10.3389/fvets.2024.1451299
Case report: Disseminated Cladophialophora bantiana phaeohyphomycosis in a dog with hepatic dysfunction, and concurrent ehrlichiosis
Provisionally accepted- 1 Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis
- 2 School of Medicine, Stanford University, Stanford, California, United States
A 1-year-old mixed breed dog initially presented with marked ascites due to a low-protein transudate resulting from portal hypertension. Laboratory evaluation revealed non-regenerative anemia, lymphopenia, thrombocytopenia, laboratory evidence of hepatic insufficiency (hypoalbuminemia, decreased urea, increased post-prandial bile acids, prolonged activated partial thromboplastin time (aPTT)) and Ehrlichia canis infection. Approximately a week later, the dog was falling declining and was euthanized. On autopsy, multifocal hepatic granulomas and acquired portosystemic shunts (APSS) were seen. Imprint cytology revealed fungal hyphae and pyogranulomatous inflammation in the liver and brain. Disseminated Cladophialophora bantiana phaeohyphomycosis was diagnosed by histologic examination, culture and PCR.Immunosuppression due to ehrlichiosis is suspected to have predisposed this animal to fungal infectionImmunosuppression is suspected to have arisen from Rickettsial disease and predisposed fungal infection. To the authors' knowledge, this is the first report of C. bantiana in the West Indies.This case appears to be the first report of C. bantiana in the West Indies.
Keywords: Fungal Infection, Hepatopathy, low-protein transudate, portal hypertension, Acquired portosystemic shunt
Received: 19 Jun 2024; Accepted: 15 Jul 2024.
Copyright: © 2024 Alonso, Fenton, Muller, Freeman, Becker, Rolph, Abramo, Rawlins, Kitson, Kessel and Thrall. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Flavio Alonso, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis
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Heather Fenton
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