AUTHOR=Johnson Jake , Melhorn Hannah , Karchemskiy Sonya , Karlin Emily , Bain Perry , Rush John , Peterson Cornelia 

TITLE=Case report: Diffuse large B-cell lymphoma presenting as congestive heart failure in a cat

JOURNAL=Frontiers in Veterinary Science

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1467448

DOI=10.3389/fvets.2024.1467448

ISSN=2297-1769

ABSTRACT=Cardiac lymphoma is uncommon in cats and is rarely considered as a differential diagnosis for congestive heart failure. A 10-year-old neutered male domestic short-haired cat with clinical histories of feline immunodeficiency virus, diabetes mellitus, and congestive heart failure was humanely euthanized. Post-mortem evaluation demonstrated a massively infiltrative round cell neoplasm of the heart, resulting in CHF. Immunohistochemistry of neoplastic tissue was consistent with diffuse large B-cell lymphoma. This case demonstrates a peculiar presentation of cardiac diffuse large B-cell lymphoma, with chronic feline lentiviral infection possibly contributing to disease initiation and progression.