AUTHOR=Yang Lan , Gao Han , Liu Dacheng 

TITLE=Advance on establishment of pathological model of ulcerative colitis

JOURNAL=Frontiers in Veterinary Science

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1618260

DOI=10.3389/fvets.2025.1618260

ISSN=2297-1769

ABSTRACT=Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic, relapsing inflammatory disorder of the gastrointestinal tract with multifactorial etiology. The etiology and pathogenesis of ulcerative colitis are diverse, so it is crucial to explore the pathogenesis through animal models. Selecting appropriate animal models is critical for advancing our understanding of UC pathogenesis and therapeutic strategies. This review discusses various UC animal models and compares their characteristics in relation to disease mechanisms and therapeutic research.