AUTHOR=Talló-Parra Marc , Muscolino Elena , Díez Juana 

TITLE=The host tRNA epitranscriptome: A new player in RNA virus infections

JOURNAL=Frontiers in Virology

VOLUME=Volume 2 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/virology/articles/10.3389/fviro.2022.1073619

DOI=10.3389/fviro.2022.1073619

ISSN=2673-818X

ABSTRACT=Viruses completely depend on the host translation machineries to express the viral proteins. Recent data reveal an unprecedented interaction of a positive strand RNA ((+)RNA) virus with the host tRNA epitranscriptome to favor viral protein expression via a specific reprogramming of codon optimality that ultimately favors decoding of the viral codons. We propose that this feature is shared by multiple (+)RNA viruses and that the involved tRNA modifying enzymes represent promising novel targets for the development of broad-spectrum antivirals.