AUTHOR=Umviligihozo Gisele , Mann Jaclyn K. , Jin Steven W. , Mwimanzi Francis M. , Hsieh Hua-Shiuan A. , Sudderuddin Hanwei , Lee Guinevere Q. , Byakwaga Helen , Muzoora Conrad , Hunt Peter W. , Martin Jeff N. , Haberer Jessica E. , Karita Etienne , Allen Susan , Hunter Eric , Brumme Zabrina L. , Brockman Mark A. TITLE=Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors JOURNAL=Frontiers in Virology VOLUME=Volume 2 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/virology/articles/10.3389/fviro.2022.917902 DOI=10.3389/fviro.2022.917902 ISSN=2673-818X ABSTRACT=
HIV-1 accessory proteins Nef and Vpu enhance viral pathogenesis through partially overlapping immune evasion activities. Attenuated Nef or Vpu functions have been reported in individuals who display slower disease progression, but few studies have assessed the relative impact of these proteins in non-B HIV-1 subtypes or examined paired proteins from the same individuals. Here, we examined the sequence and function of matched Nef and Vpu clones isolated from 29 long-term survivors (LTS) from Rwanda living with HIV-1 subtype A and compared our results to those of 104 Nef and 62 Vpu clones isolated from individuals living with chronic untreated HIV-1 subtype A from the same geographic area.