AUTHOR=Mhamadi Moufid , Sene Ousseynou , Diamanka Arfang , Mhamadi Moundhir , Mendy Marie Pedapa , Diouf Andy Mahine , Ndiaye Mignane , Barry Mamadou Aliou , Niang Sagne Samba , Traoré Mahfouz Cissé , Sall Amadou Alpha , Fall Gamou , Dia Ndongo , Faye Oumar 

TITLE=Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus

JOURNAL=Frontiers in Virology

VOLUME=Volume 4 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/virology/articles/10.3389/fviro.2024.1498672

DOI=10.3389/fviro.2024.1498672

ISSN=2673-818X

ABSTRACT=A fatal case of Crimean-Congo hemorrhagic fever virus (CCHFV) was detected in Dakar, Senegal, West Africa, in April 2023. To elucidate the mechanisms involved in this outcome, the kinetics of viral load, immunoglobulins, and cytokines were assessed using RT-qPCR and ELISA. A high IL-6 titer, low IL-10 titer, and delayed IgG response were associated with disease severity. These biomarkers may serve as predictors of disease severity, potentially aiding in early intervention and treatment strategies.