AUTHOR=Reuter Emilie , Luerweg Justus , Schneider Ruth , Klimas Rafael , Motte Jeremias , Gold Ralf , Salmen Anke 

TITLE=Case Report: Improvement of diplopia due to severe internuclear ophthalmoplegia by 4-aminopyridine documented using a novel virtual reality-based oculography headset

JOURNAL=Frontiers in Virtual Reality

VOLUME=Volume 6 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/virtual-reality/articles/10.3389/frvir.2025.1595694

DOI=10.3389/frvir.2025.1595694

ISSN=2673-4192

ABSTRACT=Internuclear ophthalmoplegia (INO) is an eye movement disorder that occurs in approximately one-third of people with multiple sclerosis (MS). We used a novel, head-mounted, virtual reality (VR)-based oculography device (PRET™, machineMD AG, Switzerland) to objectively measure oculomotor symptoms reported by a patient with MS to aid in the clinical diagnosis confirmation of INO. The patient’s symptoms, primarily diplopia, were managed successfully with 4-aminopyridine. The VR-based eye-tracking tool documented the subjective improvement in oculomotor function tracking treatment effects.