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DA-2013 Final Program

DA-2013 Final Program

 

 

 

 

 

 

DOPAMINE 2013

 

Program


Friday, MAY 24th

8:00 – 8:30                        Registration

8:30 – 10:30                        SESSION 1

                                    Topic: DOPAMINE AND REWARD

 

Room: SAYÀL           ENDOCANNABINOID/DOPAMINE INTERACTIONS AND THE PURSUIT OF REWARD

Chair: E.L. Gardner (USA) - Co-Chair: J.F. Cheer (USA)

Organizer: J. F. Cheer (USA)

-M. Melis (Italy) Enhanced 2-arachidonoylglycerol signaling in dopamine neurons as a possible marker of heightened predisposition to addiction

-C. Lupica (USA) Cocaine inhibition of synaptic GABA inputs to VTA DA neurons: Roles for serotonin and endocannabinoids

-L. Venance (France) Endocannabinoid and dopamine interact to mediate spike-timing dependent potentiation and depression

-J. F. Cheer (USA) Endocannabinoids modulate accumbal dopaminergic encoding during signaled shock avoidance

 

 

                                    Topic: DOPAMINE AND COGNITION

 

Room: QUARTÉ            DOPAMINE – RELATED LEARNING DYSFUNCTIONS IN ADDICTION

Chair: G. Hasler (Switzerland) - Co-Chair: P.N.Tobler (Switzerland)

Organizer: G. Hasler (Switzerland)

-P. Tobler (Switzerland) Role of dopamine in learning - findings from single cells and neuroimaging

-S. Flagel (USA) Parsing the role of dopamine in stimulus-reward learning: Implications for Addiction

-Q. Huys (UK) Learning processes in the development of addiction

-G. Hasler (Switzerland) Dopaminergic dysfunction and reward learning in bulimia nervosa

 

                                    Topic: DOPAMINE AND AFFECTIVE DISORDERS

 

Room: ARCHI                                    THE ROLE OF THE DOPAMINE TRANSPORTER IN HUMAN DISEASE

Chair: R.D. Blakely (USA) - Co-Chair: M. Kurian (UK)

Organizer: M. Kurian (UK)

-M. Reith (USA) The dopamine transporter: Structure, function and pharmacological considerations

-R. Blakely (USA) The Role of the Dopamine Transporter in Attention Deficit/Hyperactivity Disorder

-A. Galli (USA) De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorders

-M. Kurian (UK)

 

                                    Topic: DOPAMINE RECEPTORS

 

Room: LAZZARETTO                 DOPAMINE RECEPTORS: NEW CELLULAR MECHANISMS RELEVANT FOR CNS DISORDERS

Chair: P. Sokoloff (France) - Co-Chair: B. Le Foll (Canada)

Organizer: B. Le Foll (Canada)

-G. Collo (Italy) Critical role of dopamine D3 receptor in structural plasticity generated by exposure to drugs of addiction in mesencephalic dopaminergic neurons

-B. Le Foll (Canada) Neuronal circuitry underlying the impact of dopamine D3 receptors ligands on drug addiction

-E. A. Rabiner (UK) Evaluation of the Dopamine D3 receptor in the living brain with [11C]-(+)-PHNO PET

-I. Boileau (Canada) Title Imaging D3 dopamine receptor levels across behavioral and drug addiction: positron emission tomography / [11C]-(+)-PHNO studies

-E. Merlo-Pich (Italy) Pharmacological targeting of Dopamine D3 receptor: a review of therapeutic applications

 

10:30 – 11:00            Coffee Break

 

 

 

11:00 – 13:00            SESSION 2

                                    Topic: DOPAMINE NEURONS

 

Room: LAZZARETTO                  IS OUR LIFE STYLE KILLING OUR DOPAMINE NEURONS?

Chair: M.J.Zigmond (USA) - Co-Chair: U. Spampinato (France)

Organizer: M.J.Zigmond (USA)

-F. Cicchetti (Canada) Impact of n-3 PUFA in Parkinson's Disease: evidence from animal models

-S.A. Mandel (Israel) In the rush for green gold: can green tea delay age-progressive brain neurodegeneration?

-V.A. Russel (South Africa) Interactions between early stress and exercise in a rat model of Parkinson's Disease

-J.L. Cameron (USA) Physical activity protects the striatum against damage in non human primates

 

                                    Topic: DOPAMINE AND NEUROPLASTICITY

 

Room: QUARTÉ                 NEW INSIGHTS INTO THE DEVELOPMENT AND PLASTICITY OF DOPAMINE CONNECTIVITY

Chair: C. Flores (Canada) - Co-Chair: P. Henny (Chile)

Organizer: C. Flores (Canada)

-P. Henny (Chile) Structural and synaptic substrates of activity in dopaminergic neurons

-J. Pasterkamp (Netherlands) Molecular and genetic dissection of dopaminergic pathway development

-C. Bellone (Switzerland) Drug-evoked synaptic plasticity in the VTA: a role for calcium-impermeable, GluN3A-containing NMDARs

-C. Flores (Canada) Netrin-1 receptors organize mesocortical dopamine circuitry during adolescence

 

                                    Topic: DOPAMINE AND REWARD

 

Room: SAYÀL                 OPTOGENETIC PERTURBATION OF DOPAMINE NEURONAL CIRCUITRY

Chair: A. Bonci (USA) - Co-Chair: G. Stuber (USA)

Organizer: G. Stuber (USA)

-L. Kravitz (USA) Dissecting the striatal contributions to reinforcement and punishment

-N. Uchida (USA) Dissecting computations in the dopamine reward circuit

-T. Kash (USA) Genetic Modulation of Periaqueductal Grey Dopamine Neurons

-J. Britt (USA) The organization and behavioral consequence of discrete glutamatergic input to the nucleus accumbens

-G. Stuber (USA) Dissecting the neural circuitry that mediates reward and aversion

 

13:00 – 15:00            Lunch Break

15:00 – 17:00            SESSION 3

                                    Topic: DOPAMINE AND PARKINSON’S DISEASE

 

Room: LAZZARETTO                 TRANSCRIPTION FACTORS AS MEDIATORS OF DOPAMINE NEURODEGENERATION IN PARKINSON'S DISEASE

Chair: A. Björklund (Sweden) - Co-Chair: A. Prochiantz (France)

Organizer: M. Decressac (Sweden)

-T. Perlmann (Sweden) Transcription factors for the development and maintenance of dopamine neurons

-A. Prochiantz (France) Traveling homeoprotein transcription factors regulate mDA survival and physiology

-A. Björklund (Sweden) Nurr1 as a regulator of survival and GDNF-induced neuroprotection in adult dopamine neurons

-M. Smidt (Germany) Pitx3 is part of a homeodomain code for dopaminergic subset specification and survival

 

                                   

 

 

 

 

Topic: DOPAMINE AND REWARD

 

Room: SAYÀL                 NUCLEUS ACCUMBENS: CORE AND SHELL SPECIALIZATION IN REWARD FUNCTION?

Chair: R.A. Wise (USA) - Co-Chair: G. Di Chiara (Italy)

 Organizer: R. A. Wise (USA)

-S. Ikemoto (USA) "Drug and dopamine reward and the ventral striatum "

-R. A. Wise (USA) "Cocaine reinforcement is a shell phenomenon; cocaine satiety involves the core."

-B. J. Aragona (USA) Regional specificity of real-time dopamine transmission: implications for reward and function

-J. A. Dani (USA) Mechanistic Interactions between the Nicotinic Cholinergic and Dopaminergic Systems during Signaling and Synaptic Potentiation

 

                                    Topic: ANATOMY AND PHYSIOLOGY OF DOPAMINE SYSTEMS

 

Room: ARCHI                 THALAMOSTRIATAL SYNAPSES - ANOTHER SUBSTRATE FOR DOPAMINE ACTION

Chair: J.P. Bolam (UK) - Co-Chair: G.W.Arbuthnott (Japan)

Organizer: G.W.Arbuthnott (Japan)

-J.P. Bolam (UK) The thalamostriatal projection: a major excitatory input to the basal ganglia

-G. Halliday (Australia) Impact of thalamic changes in Parkinson's disease on the motor system

-J. Ding (USA) Formation and Function of Thalamostriatal Synapses on Striatal Medium Spiny Neurons and Choliergic Interneurons

-K. Kobayashi (Japan) Behavioral roles of thalamostriatal pathway in sensory discrimination learning

 

Topic: DOPAMINE AND REWARD

 

Room: QUARTÉ                 INDIVIDUAL DIFFERENCES IN DOPAMINE SIGNALING: ROLE IN LEARNING, RISK TAKING, AND IMPULSIVITY

Chair: A. Dagher (Canada) - Co-Chair: M. Frank (USA)

Organizer: A. Dagher (Canada)

-M. Frank (USA) Computational models of dopamine in learning and choice incentive

-A. Gjedde (Denmark) Sensation-seeking propensity is directly proportional to dopamine storage and inversely proportional to dopamine turnover in human dorsal striatum in vivo

-R. Ebstein (Singapore) Dopamine D4 Receptor (DRD4) Gene, Religious Affiliation and Spirituality Contribute to Dictator Game Altruism

-M. Leyton (Canada) Vulnerability to Addictions: Dopamine Studies in Humans

 

17:15 – 18:15             PLENARY LECTURE:

Room: SAYÀL            James M. Tepper (USA) Striatal TH Interneurons: Physiology, Pharmacology and Transmitter Release

 

18:30                                    OPENING RECEPTION


Saturday, MAY 25th

8:30 – 10:30                        SESSION 1

                                    Topic: DOPAMINE AND NEUROPLASTICITY

 

Room: SAYÀL           DOPAMINE REGULATION OF STRIATAL PLASTICITY

Chair: D.M. Lovinger (USA) - Co-Chair: M.S. Levine (USA)

Organizer: P. Belujon (USA)

-P. Belujon (USA) Altered hippocampal-accumbens synaptic plasticity in an animal model of depression

-R. Malenka (USA) Role of distinct subtypes of dopamine neurons in reward and aversion

- A. A. Grace (USA) Regulation of plasticity in the nucleus accumbens by afferent input: impact of stress

-J. Reynolds (New Zealand) Timing dependent effects of substantia nigra dopamine on sensory and motor reinforcement

 

                                    Topic: DOPAMINE AND SCHIZOPHRENIA

 

Room: LAZZARETTO           DOPAMINE-GLUTAMATE INTERACTIONS IN BRAIN AND THE TREATMENT OF SCHIZOPHRENIA

Chair: T.H.Svensson (Sweden) - Co-Chair: B. Moghaddam (USA)

Organizer: P. Sokoloff (France)

-K. Tseng (USA) 2B or not 2B modulated by dopamine: Input-specific late-adolescent emergence of NMDA-NR2B receptor-mediated synaptic transmission in the prefrontal cortex requires postsynaptic AKAP-PKA signaling

-T.H. Svensson (Sweden) Presynaptic alpha2 adrenoceptor blockage in the treatment of schizophrenia

-P. Sokoloff (France) Local and remote interactions of the dopamine D3 receptor with glutamate pathways: implications for the treatment of schizophrenia

-B. Moghaddam (USA) Glutamate -dopamine interactions and prefrontal cortex function

 

                                    Topic: DOPAMINE AND SIGNAL TRANSDUCTION

 

Room: ARCHI           DOPAMINE SIGNALING IN HEALTH AND DISEASE: MECHANISMS AND INTERVENTIONS

Chair: J.Caboche (France) - Co-Chair: M.G. Caron (USA

Organizer: G. Fisone (Sweden)

-P. Vanhoutte (France) Dopamine-glutamate receptor interplay in the striatum modulates molecular, structural and behavioral responses to cocaine

-R. Moratalla (Spain) Structural and synaptic plasticity associated with L-DOPA-induced dyskinesias in mouse models of Parkinson's disease

-G. Fisone (Sweden) Identification of molecular targets for the treatment of Parkinson's disease and L-DOPA-induced dyskinesia

-R. Brambilla (Italy) The Ras-ERK signalling pathway in the control of striatal function: from basic mechanisms to potential therapeutic approaches for hyperdopaminergic disorders

 

                                    Topic: DOPAMINE AND PARKINSON’S DISEASE

 

Room: QUARTÉ           NEURODEGENERATIVE MECHANISMS OF PARKINSON’S DISEASE AND POTENTIAL NEUROPROTECTIVE STRATEGIES

Chair: M. Morelli (Italy) - Co-Chair: M.A. Cenci (Sweden)

Organizer: L. Zecca (Italy)

-M. Morelli (Italy) Amphetamine-like drugs and degeneration of dopaminergic nigro-striatal neurons

-M. Pizzi (Italy) Late-onset parkinsonism in NF-κB/c-Rel deficient mice

-D. Sulzer (USA) Neuronal MHC-I display in T-cell mediated neurodegeneration

-L. Zecca (Italy) Neuromelanin organelle pathways and neurodegeneration in Parkinson's Disease

 

10:30 – 11:00            Coffee Break

 

 

 

11:00 – 13:00            SESSION 2

                                    Topic: DOPAMINE NEURONS

 

Room: QUARTÉ           THE REGULATION OF DOPAMINE NEURON ACTIVITY STATES AND ITS RELEVANCE TO DOPAMINE SYSTEM FUNCTION

Chair: W. Schultz (UK) - Co-Chair: B. Hyland (New Zeland)

Organizer: A. A. Grace (USA)

-A. A. Grace (USA) Tonic and phasic dopamine neuron activity and the regulation of information processing

-N. Mercuri (Italy) Membrane properties and neurotransmitter-mediated responses of mesencephalic dopaminergic neurons

-J. Roeper (Germany) Dopamine Diversity in the Substantia Nigra

-W. Schultz (UK) Extension of dopamine reward responses by generalization and pseudoconditioning

 

                                    Topic: DOPAMINE AND ADDICTION

 

Room: LAZZARETTO           STRUCTURE, REGULATION AND FUNCTION OF THE DOPAMINE TRANSPORTER

Chair: N.R. Zahniser (USA) - Co-Chair: G. Tanda (USA)

Organizer: A. H. Newman (USA)

-H.H. Sitte (Austria) The importance of kinases in the regulation of dopamine transporter-mediated efflux

-N.R. Zahniser (USA) Individual differences in acute low dose cocaine-induced locomotor activation in rats involve striatal dopamine transporters and predict cocaine addiction-like behaviors

-S. Jones (USA) Cocaine and Methylphenidate Self-Administration Produce Opposite Changes in Dopamine Transporter Function

-K. Henry (USA) Uncovering the cocaine binding site in the dopamine transporter using the cocaine-like photo affinity ligand RTI 82

-G. Tanda (USA) Preference for Distinct Functional Conformations of the Dopamine Transporter alters the Relationship Between Subjective Effects of Cocaine and Stimulation of Mesolimbic Dopamine

 

                                    Topic: DOPAMINE AND NEUROPLASTICITY

 

Room: SAYÀL           SYNAPTIC AND BEHAVIORAL PLASTICITY IN THE MESOCORTICOLIMBIC SYSTEM

Chair: C. Lüscher (Switzerland) - Co-Chair: A. Bonci (USA)

Organizer: C. Lüscher (Switzerland)

-P. Janak (USA) Illuminating the Role of Dopamine Neurons in Reward Learning

-C. Lüscher (Switzerland) Synaptic and behavioral plasticity in the mesocorticolimbic system?

-M. Mameli (France) Projection-specific synaptic plasticity in the lateral habenula

-R. Tonini (Italy) Endocannabinoid signaling in action control

 

13:00 – 15:00            Lunch Break

15:00 – 17:00            SESSION 3

                                    Topic: DOPAMINE RECEPTORS

 

Room: LAZZARETTO           DOPAMINE RECEPTOR HETEROMERIC COMPLEXES AND THEIR FUNCTION

Chair: S.R. George (Canada) - Co-chair: E. Borrelli (USA)

Organizer: S. R. George (CANADA)

-S.R. George (Canada) The dopamine D1-D2 receptor heteromer: Novel signaling and function mediated by a unique subset of neurons in basal ganglia

-P.J. McCormick (Spain) Diurnal Dopamine-Adrenergic heteromers can control melatonin production

-R. Franco (Spain) Functional and pharmacological consequences of D2 receptor-containing heteromers. Relevance of heteromer quaternary structure and loss of heteromes in L-DOPA induced dyskinetic primates

- A. Kern (USA) Growth Hormone Secretagogue Receptor (GHSR1a, aka ghrelin receptor) Antagonists as Selective Blockers of Dopamine Signaling in GHSR1a:DRD2 and GHSR1a:DRD1 Expressing Neurons

 

                                   

 

 

Topic: DOPAMINE AND ADDICTION

 

Room: QUARTÉ           DIFFERENTIAL ROLE OF THE MESOLIMBIC SYSTEM IN PSYCHOSTIMULANT VERSUS OPIATE REWARD

Chair: A. Badiani (Italy) - Co-Chair: G. Di Chiara (Italy)

Organizer: A. Badiani (Italy)

-D. Belin (France) Habitual drug seeking: from pathophysiology to treatment

-T. E. Robinson (USA) Cocaine and opioid cues: incentive salience

-J. Bossert (USA) Context-Induced Reinstatement of Heroin vs. Cocaine Seeking: Overlapping yet Distinctly Different Neuroanatomical Substrate Involvement

-A. Badiani (Italy) Heroin and cocaine reward are different: clinical and preclinical evidence

 

                                    Topic: DOPAMINE AND COGNITION

 

Room: ARCHI           MAKING SENSE OF PREFRONTAL CORTICAL DOPAMINE FUNCTION

Chair: H.L.Fields (USA) - Co-Chair: P. O'Donnell (USA)

Organizer: P. O’Donnell (USA)

-S. Floresco (USA) Dissociable regulation of different executive functions by prefrontal D1 and D2 receptors

-P. O’Donnell (USA) Adolescent Maturation of Prefrontal Cortical Function

-V. S. Sohal (USA) Optogenetic stimulation of synaptic inputs reveals novel effects of dopamine D2 receptors in prefrontal cortex

-T. Weickert (Australia) Prefrontal brain activity predicted by dopaminergic genes in healthy adults is modulated by antipsychotics in schizophrenia

 

                                    Topic: DOPAMINE AND NEUROPLASTICITY

 

Room: SAYÀL           REWARD LEARNING AND DOPAMINE

Chair: R.M. Wightman (USA) - Co-Chair: R.A. Wise (USA)

Organizer: R.M. Wightman (USA)

-G. Meredith (USA) The importance of circuit rewiring in amphetamine-associated contextual learning

-P.J. Kenny (USA) Dopamine and overeating

-J.R. Wickens (Japan) Methylphenidate specifically rescues deficient anticipatory dopamine release

-R.M. Wightman (USA) In vivo measurements of dopamine release during behavior

 

17:00 – 17:30            Coffee Break

17:30 – 18:30            PLENARY LECTURE

Room: SAYÀL            REGINA M. CARELLI (USA) Dynamics Of Mesolimbic Signaling In Learning, Decision Making And Addiction

18:30 – 20:00            POSTER SESSION I

                                    Topic: Dopamine and Parkinson's Disease

 

P001. A transcription factor-microRNA autoregulatory loop determines dopamine neuron numbers. A. Anderegg1, H-P. Lin1, G. Caronia-Brown, B. Yun, R. Johnson , B. Harfe, R. Awatramani*.

P002. Effects of antidepressant drugs in a rat model of depression in preclinical stages of Parkinson's disease. Klemencja Berghauzen-Maciejewska, Jadwiga Wardas, Katarzyna Kuter, Wacław Kolasiewicz, Urszula Głowacka, Krystyna Ossowska.

P003. Cognitive impairment and abnormal dentate gyrus plasticity in Parkinson's disease. Bonito-Oliva A., Pignatelli M., Spigolon G., Seiler S., Yoshitake T., Kehr J., Mercuri N., Nisticó R., Fisone G.

P004. Longitudinal automated gait analysis of the MitoPark mouse, a model of progressive dopaminergic cell loss. M. Ronild, D.R. Andersson Clarke.

P005. Calpains inhibition increases striatal TH-immunoreactive neurons in hemiparkinsonian rats treated with L-DOPA. Christine Robitaille, Laure Chagniel, Geneviève Bureau and Michel Cyr.

P006. Nitric oxide modulates rotational behaviour: a comparison between selective D1, D2 receptor agonists and L-DOPA in a rat model of Parkinson's disease. A. Czarnecka*, T. Lenda, J. Konieczny, K. Kamińska, E. Lorenc Koci.

P007. Establishing a cell line model to study tyrosine hydroxylase deficiency. Héctor Díez*, Carlos Ortez, Noelia Fernández, Mercè Izquierdo, Pau Gorostiza, Bru Corman, Artur Llobet, Rafael Artuch, Àngels Garcia-Cazorla.

P008. MSK1 mediates L-DOPA-induced dyskinesia in an experimental Parkinsonian mouse model via expression of delta FosB. Michael Feyder, Emanuela Santini, Erik Södersten, Giada Spigolon, Klaus Hansen, Jocelyne Caboche, Vincent Vialou, Eric J Nestler, Gilberto Fisone.

P009. Antidyskinetic effect of memantine and amantadine in the rat Parkinson's disease model. C. Fidalgo, E. Tronci, C. Lisci, M. Collu, R. Stancampiano, M. Carta.

P010. Involvement of dopamine in generation of oxidative stress in a 6-hydroxy-dopamine-induced partial dopaminergic striatal lesion model in the rat. Y. Aluf, J. Vaya, S. Khatib, J.P.M. Finberg.

P011. Atypical dopamine transporter deficiency syndrome in an adult male: Molecular characterization of new transporter variants. Freja H. Henriksen, Tina Skjørringe, Saiqa Yasmeen, Natascha V. Arends, Thorvald Fauerschou Andreassen, Kevin Erreger, Aurelio Galli, Merete Karlsborg, Lena E. Hjermind, Lisbeth Birk Møller, Ulrik Gether.

P012. The stoichiometry of protomers in the complexes formed between tyrosine hydroxylase maximally phosphorylated at Ser19 and 14-3-3. Jorge-Finnigan Ana, Kleppe Run, Rosati Sara, Alvira Sara, Valpuesta José María, Haavik Jan, Heck Albert JR and Martinez Aurora.

P013. Behavioral and biochemical effects of combined treatment with l-dopa and tricyclic antidepresants in 6-ohda-lesioned rats. Kinga Kamińska, Tomasz Lenda, Anna Czarnecka, Jolanta Konieczny, Elżbieta Lorenc-Koci

P014. Mice with genetically evoked selective loss of noradrenergic system as a possible tool to study presymptomatic phase of Parkinson's Disease. Grzegorz Kreiner, Agnieszka Jurga, Marta Kot, Katarzyna Rafa-Zablocka, Monika Baginska, Rosanna Parlato, Guenther Schuetz, Wladyslawa A. Daniel, Irena Nalepa.

P015. Behavioral evidence of a hyperdopaminergic phenotype in LRRK2 G2019S mice. Longo F. & Morari M.

P016. Aberrant GABAergic tonic inhibition is present in the GP of parkinsonian rodents. Miguelez C, Morin S, Chazalon M, Ugedo L, Baufreton J.

P017. Enhanced vesicular storage to reduce dopamine toxicity. GW Miller, A Salahpour, A Bernstein, K Lohr, T Guillot, E Heath, K Stout, M Wang, Y Li

P018. The pathophysiology of Parkinson's disease: LRRK2, neurotransmission and synaptic maintenance. Beccano-Kelly D.A., Volta M., Co K., Chou P., Tatarnikov I., Cao L.P., Munsie L.N., Tapia L., Melrose H., Raymond L.A., Farrer M.J. & Milnerwood A.M.

P019. Direct generation of dopamine cells from fibroblasts and assessment of their therapeutic potential in animal models of Parkinson disease. Mus L., Caiazzo M., Leo D., Gainetdinov R.R.

P020. Elaboration of a rat model of depression present in preclinical stages of Parkinson's disease. Krystyna Ossowska1, Klemencja Berghauzen-Maciejewska, Katarzyna Kuter, Wacław Kolasiewicz, Anna Dziubina, Krystyna Gołembiowska, Jadwiga Wardas

P021. A new therapeutic strategy for Parkinson's disease. Pinna A., Costa G., Simola N., Tronci E., Carta M., Morelli M.

P022. Role of the transcription factor Pitx3 in modulating vulnerability of midbrain dopaminergic neurons to neurodegenerative stress. Abbas F Sadikot, Kelvin C Luk, Vladimir V Rymar, Pepijn van den Munckhof, Stefan Nicolau, Claude Steriade, Panojot Bifsha, Jacques Drouin

P023. Role of dopamine D3R/nAChR heterodimeric complex in the regulation of dopaminergic neurons function. P.Savoia*, C.Fiorentini, J.Grigoletto, A.Bellucci and C.Missale

P024. Down-regulation of the D1R/Shp-2/Erk1/2 pathway ameliorates L-DOPA-induced dyskinesia in the 6-Hydroxy-Dopamine rat model of Parkinson's disease. D. Savoldi*, P.Savoia, A. Prandini, C. Fiorentini, C. Missale

P025. Susceptibility of dopaminergic and GABAergic neurons in the rat substantia nigra to toxicity of the selective proteasome inhibitor lactacystin: in vivo study. T. Lenda*, A. Czarnecka, P. Nowak, K. Kamińska, E. Lorenc-Koci, J. Konieczny

P026. Effect of the serotonin precursor 5-hydroxytryptophan on L-DOPA-induced dyskinesia in parkinsonian rats. E. Tronci, C. Lisci, R. Stancampiano, P. Devoto, M. Collu, M. Carta.

P027. Dopamine-dependence of murine LRRK2 associated behaviors. M Volta; D. Beccano-Kelly; L. Tapia; C. Vilarino-Guell; K. Co; P. Chou; A. Huang; K. Yu; S. Bergeron; H. Melrose; M Farrer; A Milnerwood

P028. Impaired dopaminergic neurotransmission and vesicular recycling in human LRRK2 (R1441G) transgenic mice. SJ Choi, Y Huang, CJ Li and H Zhang*

 

                                   

Topic: Dopamine Co‐Transmission

 

P 029. Contribution of TAAR1 receptors in effects of apomorphine. I. Sukhanov, S. Espinoza, D.S. Yakovlev, M.C. Hoener M, T.D. Sotnikova, R.R Gainetdinov

 

                                    Topic: Anatomy and Physiology of Dopamine Systems

 

P030. Characterizing dopamine release and clearance in the striatum of c57/Bl6 mice using in vivo chronoamperometry. E. Arvidsson, Å. Mackenzie

P031. Role of Trace amine-associated receptor 1 (TAAR1) in the modulation of dopaminergic system and cortico-striatal signaling. S. Espinoza, I. Sukhanov, G. Lignani, L. Medrihan, D. Leo, S. Maggi, G. Giannotti, F. Fumagalli, F. Benfenati, V. Tucci, R. Gainetdinov

P032. Analysis of Glutamate, GABA, Noradrenaline, Dopamine, Serotonin and Metabolites using microbore UHPLC with electrochemical detection. M. Eysberg, V.Valentini, H.-J. Brouwer, N. J. Reinhoud, L. M. van Heerwaarden

P033. Spatial distribution of D1R- and D2R-expressing Medium-sized Spiny Neurons differs along the rostro-caudal axis of the Dorsal Striatum. G. Gangarossa, J. Espallergues, P. Mailly, A. De Kerchove D'Exaerde, D. Hervé, J. Antoine Girault, P. Krieger, E. Valjent.

P034. Reward responses of presumed dopamine neurons in the dorsal raphe nucleus. B. Hyland, Y. Li

P035. Taar1-mediated modulation of dopaminergic neurotransmission. D. Leo, S. Espinoza, M.C. Hoener, T. Sotnikova, R.R Gainetdinov.

P036. Immunocytochemical detection of PSD-95, TH and Golgi-Cox stained elements: visualization in the same slice. G. Mulas, S. Spiga, M. Diana

P037. Sex-specific effect of COMT on cortical anatomy. S. Sannino*, A. Gozzi, A. Cerasa, D. Scheggia, F. Managò, D. De Pietri Tonelli, A. Bifone, G. Spalletta, D. R. Weinberger, F. Papaleo

P038. Anatomical and functional characterization of the cortical input to D1 or D2 receptor-expressing striatal neurons. G. Spigolon, D. Fürth, A. Bonito-Oliva, Y. Xuan, I. Pollak Dorocic, E. Yoo, P. Krieger, M. Carlén, K. Meletis, G. Fisone

P039. Activity of VTA DA neurons induces a homeostatic plasticity of GIRK channels. K.R. Tan, A. Lalive, M. Munoz, P. Slesinger, C. Lüscher


 

                                    Topic: Dopamine and Cognition

 

P040. The positive allosteric modulator of nicotinic alpha 7 cholinergic receptors, AVL-3288, stimulates cathecolamine release in the prefrontal cortex and nucleus accumbens shell of adolescent rats: potential utility in ADHD?. R. Cadeddu, M. Ibba, T. Johnstone, D. Hogenkamp, K.W. Gee and E. Carboni.

P041. Methylphenidate enhances cognitive stability at the expense of cognitive flexibility. Fallon.S.J., van der Schaaf, M., ter Huurne, N., Cools, R

P042. The Role of Midbrain Dopamine in Predictive Fear Learning. S. Li; G. P. McNally

P043. Impact of cortical alpha-synuclein overexpression on the performance in operant tasks of cortico-striatal function. Hanna S. Lindgren, Alex Klein,Andreas Heuerand Stephen B. Dunnett.

P044. Stuck in a loop: pre-training methamphetamine speeds up transition to habit dominated behavior. H. Pacitti, B. Balleine* & S. Killcross; Helena Pacitti

P045. Dysbindin-1 genetic disruption modulates cognitive flexibility in mice. D. Scheggia*, G. Kochlamazashvili, A. Dityatev, F. Papaleo

 

                                    Topic: Dopamine and Neurodegeneration

 

P046. The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease. Eleftheria K. Pissadaki and J. Paul Bolam

P047. Vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity in adolescent mice chronically treated with 3,4-methylenedioxymethamphetamine (MDMA). Costa G., Frau L., Pinna A., Wardas J., Morelli M.

P048. SH-SY5Y neuroblastoma cells as a tool for studying designer drug toxicity - results on "bath salt" mephedrone. B. den Hollander, S. Rozov, I. Ojanperä, E. Kankuri, E. Korpi

P049. Effect of caffeine on the release of DA, 5-HT and production of hydroxyl radical induced by methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse striatum. Krystyna Gołembiowska, Anna Maria Górska, Katarzyna Kamińska

P050. A translational study on Dopamine Transporter Deficiency Syndrome: development of new animal models. Placido Illiano, Jean-Martin Beaulieu, Claude Lamarre, Raul R. Gainetdinov

 

                                    Topic: Imaging Dopamine

 

P051. Transgenic expression of GCaMP calcium indicator in dopaminergic neurons for optogenetic measurement of presynaptic calcium transients in striatum. C. Sgobio, G. Cui, Z. Li, D. M. Lovinger, H. Cai


Sunday, MAY 26th

8:30 – 10:30                        SESSION 1

                                    Topic: DOPAMINE AND REWARD

 

Room: LAZZARETTO           GENETIC AND FUNCTIONAL DISSECTION OF THE DOPAMINE D2 RECEPTOR IN MOTOR AND REWARD – MEDIATED BEHAVIORS

Chair: M. Rubinstein (Argentina) - Co-Chair: V.A. Alvarez (USA)

Organizer: M. Rubinstein (Argentina)

-V.A. Alvarez (USA) D2 receptors on striatal and dopaminergic neurons play different roles in mediating cocaine reward and locomotor responses

-A. De Kerchove (Belgium) Roles of two efferent dopaminoceptive neuronal populations of the striatum in addiction and motor control: a transgenic approach

-D. Lovinger (USA) Synaptic Plasticity in Direct and Indirect Pathway Striatal Projection Neurons

-M. Rubinstein (Argentina) Spatial and temporal genetic dissection of Drd2 expression reveals an expanded functional repertoire of the dopamine D2 receptor

-J.T. Williams (USA) Dopamine-dependent transmission in the substantia nigra

 

                                    Topic: DOPAMINE AND NEUROPLASTICITY

 

Room: ARCHI           DOPAMINERGIC IMPACT ON NEUROPLASTICITY AND COGNITION IN ANIMALS AND HUMANS: A TRANSLATIONAL APPROACH

Chair: S. Otani (Japan) - Co-Chair: M.A.Nitsche (Germany)

Organizer: M. A. Nitsche (Germany)

-Y. Goto (Japan) Dopamine-dependent synaptic plasticity in cortico-limbic information processing

-S. Otani(Japan) Functional and dysfunctional plasticity inductions in rodent prefrontal cortex

-M.A. Nitsche (Germany) Dopaminergic impact on neuroplasticity in humans

-H. DenOuden (Netherlands) Dissociable roles of dopamine and serotonin transporter polymorphisms in reversal learning

 

                                    Topic: ANATOMY AND PHYSIOLOGY OF DOPAMINE SYSTEMS

 

Room: QUARTÉ           LOCAL REGULATION OF STRIATAL DOPAMINE RELEASE

Chair: E.M. Rice (USA) - Co-Chair: P. Phillips (USA)

Organizer: M. E. Rice (USA)

-S.J. Cragg (UK) Axonal Control of Striatal Dopamine Transmission by ACh

-J.C. Patel (USA) Rapid inhibition of dopamine release by endogenous dynorphin and kappa opioid receptors in ventral but not dorsal striatum

-A.R. West (USA) Striatal nitric oxide and dopamine interactions

-M.E. Rice (USA) Hydrogen peroxide (H2O2) as a modulator of striatal dopamine release

 

                                    Topic: DOPAMINE AND ADDICTION

 

Room: SAYÀL           DOPAMINE-MEDIATED REWARD AND REINFORCEMENT IN PRECLINICAL DISEASE MODELS

Chair: L.J. Porrino (USA) - Co-Chair: K.M. Kantak (USA)

Organizer: K.M. Kantak (USA)

-L.J. Porrino (USA) Development of Dopamine Systems in Childhood and Adolescence

-E.M. Unterwald (USA) Altered dopaminergic function and reward sensitivity in a rat model of Post-Traumatic Stress Disorder

-S. Izenwasser (USA) Sexually dimorphic changes in reward and the dopamine system in a rodent model of diet-induced obesity

-K.M. Kantak (USA) Cocaine Abuse Liability in a Rodent Genetic Model of ADHD: Comparison of Stimulant and Non-Stimulant Medication during Adolescence

 

10:30 – 11:00            Coffee Break

 

 

 

 

11:00 – 13:00            SESSION 2

                                    Topic: DOPAMINE AND PARKINSON’S DISEASE

 

Room: QUARTÉ           NEW MODELS OF NEURODEGENERATION FOR EXPERIMENTAL PARKINSON’S DISEASE

Chair: F. Blandini (Italy) - Co-Chair: G.U.Corsini (Italy)

Organizer: F. Blandini (Italy)

-M.G. Spillantini (UK) Alpha-synuclein dysfunction affects the dopaminergic system in a transgenic mouse model

-F. Blandini (Italy) Central dopaminergic denervation affects splanchnic organ functions

-A.R. Carta (Italy) The chronic MPTPp mouse model of progressive Parkinson disease

-M.T. Herrero (Spain) The importance of the primate model of Parkinsonism

-Y. Wu (China) Role of mTOR signaling pathway in dopamine D2 receptor-mediated suppression of neuroinflammation

 

                                    Topic: DOPAMINE AND ADDICTION

 

Room: SAYÀL           ETHANOL-MECHANISMS ALONG THE MESOLIMBIC DOPAMINE SYSTEM

Chair: M. Ericson (Sweden) - Co-Chair: I. Diamond (USA)

Organizer: E. Jerlhag (Sweden)

-E. Jerlhag (Sweden) The role of gut-brain hormones in reward from addictive drugs

-P. Steensland (Sweden) The monoamine stabilizer (-)-OSU6162 attenuates voluntary ethanol intake and ethanol-induced dopamine output in the nucleus accumbens

-M.S. Brodie (USA) Actions of ethanol on protein kinase C function affecting dopaminergic ventral tegmental area neurons

-H. Morikawa (USA) Dopamine Neuron Plasticity in Alcoholism

 

                                    Topic: DOPAMINE AND SIGNAL TRANSDUCTION

 

Room: ARCHI           THE IMPACT OF STEROIDS ON DOPAMINE NEUROTRANSMISSION

Chair: M. Bortolato (USA) - Co-Chair: T. Di Paolo (Canada)

Organizer: M. Bortolato (USA)

-T. Di Paolo (Canada) Implication of the membrane estrogen receptor GPER1 in estrogenic neuroprotection and neuromodulation of brain dopamine

-C. Frye (USA) Progestogens mediate mating behavior of rodents in part through dopamine signalling in the ventral tegmental area

-P.E.M. Phillips (USA) Phasic dopamine transmission in the striatum during drug use

-M. Bortolato (USA) Neurosteroids as dopaminergic modulators: neurobiological mechanisms and clinical implications

-C. Shannon-Weickert (Australia) Dopamine D2 Receptor Abnormalities in Schizophrenia: Possible Modulation by Sex Steroids and Genotype

 

                                    Topic: DOPAMINE AND SCHIZOPHRENIA

 

Room: LAZZARETTO           DOPAMINERGIC FUNCTION IN MICE MUTANT FOR SCHIZOPHRENIA-RELATED GENES: CONVERGENCE OR DIVERGENCE?

Chair: J.L.Waddington (Ireland) - Co-Chair: T.H. Svensson (Sweden)

Organizer: J.L. Waddington (Ireland)

-F. Papaleo (Italy) Dysbindin-1 modulates cognitive deficits relevant to schizophrenia via dopamine pathways

-P. Moran (UK) D-amphetamine and antipsychotic drug effects on Latent Inhibition in mice lacking dopamine D2 receptors

-H. Nawa (Japan) Vulnerability of dopaminergic development to neuregulin-1 and EGF; Implication in schizophrenia-related behavioral deficits

-C.M. O’Tuathaigh (Ireland) A mouse mutant model with disruption of two schizophrenia risk genes: dopaminergic modulation of schizophrenia-relevant phenotypes

 

13:00 – 15:00            Lunch Break

20:00                                    Social Dinner


Monday, MAY 27th

8:30 – 10:30                        SESSION 1

                                    Topic: DOPAMINE AND PARKINSON’S DISEASE

 

Room: QUARTÉ           PRE‐SYNAPTIC AND POST‐SYNAPTIC MECHANISMS IN L‐DOPA‐INDUCED DYSKINESIA

Chair: M. Carta (Italy) CoChair: G. Fisone (Sweden)

 Organizer: M. Carta (Italy)

A. Cenci (Sweden) Pre- and post-synaptic mechanisms in L-DOPA-induced dyskinesia

P. Piccini (UK) Pre-and post-synaptic mechanisms in L-DOPA-induced dyskinesia (LID): evidence from functional neuroimaging studies in PD

E. Bezard (France) Lentiviral-mediated silencing of PSD-95 diminishes L-DOPA-induced dyskinesia in experimental parkinsonism

M. Carta (Italy) 5-HT1 receptor agonists for the treatment of L-DOPA-induced dyskinesia: toward clinical investigation

 

                                    Topic: DOPAMINE AND REWARD

 

Room: LAZZARETTO           DOPAMINERGIC INVOLVEMENT IN EFFORT–RELATED ASPECTS OF MOTIVATION

Chair: M. Correa (Spain) CoChair: S. Ikemoto (USA)

Organizer: J.D. Salamone (USA)

X. Zhuang (USA) Dopamine, economic decision making and energy balance

W. Hauber (Germany) Cost/benefit-related decisions in rats: role of dopamine and effects of dopaminergic drugs

J.G. Hosking (Canada) Cognitive versus physical effort: dopaminergic manipulation has dissociable effects on two rodent models of cost/benefit decision making

J.D. Salamone (USA) Development of animal models of the effort-related motivational symptoms of depression: Dopaminergic Mechanisms

M. Treadway (USA) Effort-related DA function and Motivational deficits in Psychopathology

 

                                    Topic: DOPAMINE COTRANSMISSION

 

Room: SAYÀL           THE MULTILINGUAL NATURE OF DOPAMINE NEURONS

Chair: D.L. Sulzer (USA) CoChair: J.M. Tepper (USA)

Organizer: L.E.Trudeau (Canada)

L.E. Trudeau (Canada) Regulation and developmental role of the vesicular glutamate transporter VGLUT2 in dopamine neurons

S. Rayport (USA) The dopamine neuron functional connectome

T. Hnasko (USA) Biophysical evidence for the vesicular co-packaging of glutamate with dopamine

M. Morales (USA) Subcellular Segregation of Dopaminergic and Glutamatergic Signaling by VTA Neurons

A.W. Mackenzie (Sweden) Vglut2-mediated glutamate release in the ventral midbrain

 

                                    Topic: DOPAMINE NEURONS

 

Room: ARCHI           SEROTONIN‐DOPAMINE INTERACTION: NEW OPPORTUNITIES FOR IMPROVED TREATMENTS OF DOPAMINE‐RELATED DISORDERS

Chair: K.A. Cunningham (USA) CoChair: U. Spampinato (France)

 Organizer: K. Cunningham (USA)

K. Cunningham (USA) Oppositional Control of Dopamine-Mediated Behaviors by Serotonin 5-HT2A and 5-HT2C Receptors: Implications for Pharmacotherapeutics in Addictions

J. Neumaier (USA) 5-HT6 receptor oppose dopamine in striatum

U. Spampinato (France) 5-HT2B receptors-DA interaction: control of DA ascending pathways and therapeutic implications

A. NewmanTancredi (France) Biased agonism at pre or post-synaptic serotonin 5-HT1A receptors: therapeutic relevance for dopaminergic dysfunction

V. Valentini (Italy) 5HT/DA system interactions in the reinforcing properties of psychostimulants: role of 5-HT6 receptors

 

10:30 – 11:00            Coffee Break

 

11:00 – 13:00            SESSION 2

                                    Topic: DOPAMINE AND SCHIZOPHRENIA

 

Room: ARCHI           DA RECEPTORS AND THEIR INTERACTIONS WITH OTHER MONOAMINE RECEPTOR MECHANISMS REMAIN A TARGET FOR TREATMENT OF SCHIZOPHRENIA

Chair: P.F. Spano (Italy) CoChair: K. Fuxe (Sweden)

Organizer: K.Fuxe (Sweden)

K. Sahlholm (USA) Reversibility of antagonism at the dopamine D2 receptor - how different are typical and atypical antipsychotics?

T.H.Svensson (Sweden) Dopamine, D1 receptors and noradrenergic mechanisms in the mode of action of antipsychotic drugs

K. Fuxe (Sweden) D2 receptor heteromers in the ventral striatum as targets for novel antipsychotic drugs

S. Tanganelli (Italy) Neurotensin receptor NT1 and dopamine receptor D2 heteromers as a target for antipsychotic drugs

 

                                    Topic: DOPAMINE AND ADDICTION

 

Room: SAYÀL           DA ROLE IN THE ADDICTED BRAIN: FROM SYNAPSES TO HUMAN BRAIN IMAGING

Chair: M. Diana (Italy) CoChair: D. Martinez (USA)

Organizer: A. Bonci (USA)

S. Russo (USA) Mechanisms of synaptic plasticity in addiction and depression

G.F. Koob (USA) The role of dopamine in addiction: Neuroplasticity from the dark side

N.D. Volkow (USA) The Role of Dopamine in the Addicted Human Brain

A. Bonci (USA) Optogenetic control of the prelimbic cortex: implications for cocaine craving

C. Gipson (USA) Prelimbic cortex and ventral tegmental area modulate nucleus accumbens core synaptic plasticity during cue- and cocaine-reinstated drug seeking

 

                                    Topic: DOPAMINE NEURONS

 

Room: QUARTÉ           BEATING AND BURSTING: THE JOYFUL NOISE OF DOPAMINE NEURONS

Chair: P. Shepard (USA) CoChair: J. Roeper (Germany)

Organizer: P. Shepard (USA)

V. Seutin (Belgium) Activity of dopaminergic neurons in freely moving rats: a new insight into the dynamics of the ventral tegmental area

C.A. Paladini (USA) Dopamine neurons require two inputs for bursting

P. Shepard (USA) Ether-a`-go-go-related gene potassium channels in midbrain dopamine neurons: Implications for a role in depolarization block

C. Canavier (USA) Analysis of depolarization block and bursting in dopamine neurons

K. Herrik (Denmark) Dopamine Beat Box

 

                                    Topic: DOPAMINE NEURONS

 

Room: LAZZARETTO           NEUROENDOCRINE DOPAMINE NEURONS: PHYSIOLOGY, REGULATION AND CLINICAL ROLE

Chair: M. Zigmond (USA) CoChair: C. Broberger (Sweden)

Organizer: C. Broberger (Sweden)

D. Grattan (New Zealand) Signal transduction pathways mediating prolactin-induced activation of tuberoinfundibular dopamine neurons

C. Broberger (Sweden) Electrophysiology of tuberoinfundibular dopamine (TIDA) neurons: network properties and modulation

A. Martin (France) TIDA neurons plasticity: The functional switch

P. Velez (USA) Electrophysiological Studies of TIDA Neurons From Female Rodents

 

13:00 – 15:00            Lunch Break

 

 

 

15:00 – 17:00            SESSION 3

                                    Topic: DOPAMINE AND NEURODEGENERATION

 

Room: QUARTÉ           A‐SYNUCLEIN INDUCED TOXICITY: SYNAPTIC DYSFUNCTION AND NEURODEGENERATION IN DOPAMINE NEURONS

Chair: P.F. Spano (Italy) CoChair: R. Malenka (USA)

Organizer: A. Bjorklund (Sweden)

D. Rubinsztein (UK) Autophagy and Neurodgeneration

T. Outeiro (Portugal) Extracellular alpha-synuclein induces neuronal dysfunction and toxicity

P.F. Spano (Italy) Alpha-synuclein regulates synapsin I and III in developing and mature dopaminergic neurons: implications for Parkinson’s disease

M. Decressac (Sweden) Validation of therapeutic targets against alpha-synuclein toxicity in vivo

 

                                    Topic: DOPAMINE RECEPTORS

 

Room: ARCHI           MOLECULAR DETERMINANTS OF D2 AND D3 RECEPTOR SELECTIVITY AND EFFICACY

Chair: D.R. Sibley (USA) CoChair: J.C. Schwartz (France)

Organizer: D. Sibley (USA)

D. Sibley (USA) Identification of a novel dopaminergic ligand that is a biased agonist at the D2 dopamine receptor and an antagonist at the D3 receptor

A.H. Newman (USA) Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

J. Javitch (USA) Identification of a bitopic ligand that acts as a negative allosteric modulator across a dopamine D2 receptor dimer

L. Shi (USA) Identification of a second binding pocket for the subtype selectivity at dopamine D3 and D2 receptors

J.C. Schwartz (France) The D3R from discovery to clinical trials indrug abuse with BP1.4979, a partial agonist

 

                                    Topic: DOPAMINE AND COGNITION

 

Room: LAZZARETTO           MOLECULAR IMAGING OF DOPAMINE NEUROTRANSMISSION DURING HUMAN COGNITIVE PROCESSING

Chair: R.D. Badgaiyan (USA) CoChair: A. Dagher (Canada)

Organizer: R.D. Badgaiyan (USA)

L. Backman (Sweden) Cognitive and brain plasticity: The role of dopamine

A. Strafella (Canada) Imaging Cognitive Dysfunction in Parkinson's Disease

G.R. SamanezLarkin (USA) Individual differences in dopaminergic neuromodulation of reward processing and cognition

R.D. Badgaiyan (USA) Molecular imaging of dopamine neurotransmission during human cognitive processing

 

                                    Topic: DOPAMINE NEURONS

 

Room: SAYÀL           IMPACT OF NETWORK ACTIVITY ON THE INTEGRATIVE PROPERTIES OF DOPAMINE NEURONS IN RESPONSE TO NATURAL REWARDS,DRUGS AND AVERSIVE EVENTS

Chair: F. Georges (France) CoChair: M. Ungless (UK)

Organizer: F. Georges (France)

F. Georges (France) Modulation of dopamine neuron activity by afferents: Implications in reward and aversion

M. Ungless (UK) Functional diversity of dopamine neurons

F. Chaouloff (France) Cannabinoid type-1 receptors on ventral tegmental area GABAergic neurons control voluntary exercise performance in mice

G. AstonJones (USA) Linking context with reward

 

17:00 – 17:30            Coffee Break

17:30 – 18:30            PLENARY LECTURE

Room: SAYÀL            Emiliana Borrelli (USA) The Multiple Facets Of Dopamine D2 Receptor Signaling

 

18:30 – 20:00            Technology Transfer Workshop

Room: SAYÀL                  VISUALIZING DA NETWORKS IN THE BRAIN AND THEIR RELATIONSHIPS TO THE NETWORKS THEY TARGET.

Chair: K. Fuxe (Sweden) CoChair: P.F. Spano (Italy)

-S. Spiga/G. Mulas/M.Diana (Unica/Uniss, Italy) Spine plasticity in the Nucleus Accumbens: confocal analysis.

M. Wu (Neurodigitech, CA, USA) High-throughput quantitation of 3D neuronal morphology

J.P. Bolam (Oxford, UK) Dopamine neurons: activity, chemistry and connections

G.E. Meredith (USA) Structural plasticity of medium spiny neurons: Dopamine-induced changes

Discussants: J.M. Tepper; H.L. Fields

 

18:30 – 20:00            POSTER SESSION II

                                    Topic: Dopamine and Addiction

 

P052. Striatal Dopamine Transporter Availability in Patients with Alcohol Dependence: Assessment by 123I-FP-CIT SPECT. A Pilot Study. A. Ferrulli, G. Vassallo, M. Antonelli, A. Mirijello, C. D’Angelo,D. Di Giuda, A. Giordano, *M. Diana, G. Addolorato

P053. Striatal Modulation of BDNF Expression using MicroRNA124a-Expressing Lentiviral Vectors Impairs Ethanol- Induced Conditioned- Place Preference and Voluntary Alcohol Consumption. A. Bahi, J-L. Dreyer

P054. Changes of dopamine transmission in the nucleus accumbens shell and core during ethanol and sucrose self-administration. V. Bassareo, F. Cucca, R. Frau, G. Di Chiara

P055. Genotype dependent adaptive changes in mesolimbic dopamine transmission after adolescent nicotine exposure: possible underlying mechanisms in the gateway effect of nicotine. Cristina Cadoni, Elena Espa, Gaetano Di Chiara

P056. Vulnerability to Addictions: Dopamine Studies in Humans. K.F. Casey, E. Setiawan, I. Boileau, A. Fotros, S.P. Barrett, A. Dagher, C. Benkelfat, M. Leyton

P057. Individual contributions of drug and cues to striatal phasic dopamine signals during self-administration. L.M. Burgeno, I.Willuhn, P.EM. Phillips

P058. Altered response to stress in animals exposed to chronic cocaine treatment during adolescence. L. Caffino, G. Giannotti, G. Racagni, F. Fumagalli

P059. Cocaine self-administration results in neurochemical tolerance and dopamine transporter complex formation which is reversed by a single amphetamine bolus. E.S. Calipari, M.J. Ferris, J.H. Rose, D.CS. Roberts, S.R. Jones

P060. Acetaldehyde operant self-administration in rats: focus on D2-receptor activation. A. Brancato, R.A.M. Marino, F. Plescia, F.M. Sutera, C. Cannizzaro

P061. Ketamine produces structural plasticity of mouse mesencephalic dopaminergic neurons via activation of Akt-mTOR pathway: role of dopamine D3 receptor. L. Cavalleri, F. Bono, V. Tedesco, M. Di Chio, E. Merlo Pich, P.F. Spano, C. Missale, C. Chiamulera, G. Collo.

P062. Oxytocin decreases methamphetamine seeking in an animal model of relapse. B.M. Cox, R.E. See, C.M. Reichel

P063. Pharmacological characterization of JWH-018, a cannabinoid component of  “spice” drugs. M.A. De Luca, P. Caboni, Z. Bimpisidis, V. Valentini, G. Margiani, G. Marsicano,  M. Melis, M. Marti & G. Di Chiara

P064. Loss of control over food intake, observations from an animal model. J.W. de Jong, T.J.M. Roelofs, K.E. Meijboom, L.J.M.J. Vanderschuren, R.A.H. Adan

P065. JPC-077 interacts with VMAT2 to reduce the neurochemical and behavioral effects methamphetamine.

L.P Dwoskin, J.R. Nickell, J.S. Beckmann, E.D. Denehy, K.B. Siripurapu, J.P. Culver, P.A. Crooks, and M.T. Bardo

P066. The ethanol intake-reducing effect of acamprosate is associated with dopamine elevation. M. Ericson, P. Chau, B. Söderpalm

P067. Effects of the monoamine stabilizer (-) OSU6162 on dopamine output in the nucleus accumbens in rats after long-term voluntary ethanol drinking. K. Feltmann, B. Schilström, P. Steensland; Kristin Feltmann

P068. Dopamine D3 receptors and incubation of cocaine craving.

E.L. Gardner, X. Li, J. Li, X-Q. Peng, R. Song, J. Gaal, Z-X. Xi

P069. Role of the Lateral Habenula and Tail of the Ventral Tegmental Area in Reinstatement of Cocaine Seeking. M.J. Gill, J. Kaufling, R.E. See RE

P070. Orexin signaling in the ventral tegmental area is critical for cue-induced reinstatement of cocaine-seeking but not natural reward-seeking behavior. M.H. James, E.M. Levi, J.W. Yeoh, D.W. Smith, C.V. Dayas

P071. Kappa-Opioid Receptors in the Nucleus Accumbens Shell are Important for Pair Bond-induced Attenuation of Amphetamine-induced Conditioned Place Preference. P.C. Keyes, S.L. Resendez, C.J. Austin, B.J. Aragona

P072. Delta9-THC and heroin exposure in adolescence differently affect heroin self-administration in adulthood D. Lecca, C. Cadoni, V. Valentini, G. Piras, A. Scifo, G. Di Chiara.

P073. Elevated activity of dopamine neurons during adolescence: implications for cocaine addiction. J.E. McCutcheon, W.C. Wong, M. Marinelli

P074. Dopamine involvement in Acetaldehyde drinking behaviour: role of Ropinirole on. R.A.M. Marino, A. Brancato, F. Plescia, C. Gagliardo, G. Gambino, C.Cannizzaro

P075. A Glucocorticoid Antagonist Shows Therapeutic Potential for Alcohol Dependence in a POC Human Laboratory Study. B.J. Mason

P076. Dopamine system adaptations in alcohol abstinence: Translational evidence from humans and rats for a hyperdopaminergic state. M. Meinhardt, N. Hirth, L. Broccoli, S. Perreau-Lenz, R.Rimondini, C. Harper, M. Heilig, R. Spanagel, W. Sommer, A. Hansson

P077. Characterization of input-specific innervation of the lateral habenula after exposure to drugs of abuse. F. Meye, M. Mameli

P078. Zinc modulates ethanol-induced dopamine output in the rat nucleus accumbens. J. Morud, L. Adermark, M. Ericson, B. Söderpalm

P079. D-TMS in cocaine addiction: preliminary findings. M. Pedetti, R. Panella, A.G. Frascella, M. Diana.

P080. Reversal of cocaine-evoked synaptic plasticity removes addiction related behaviors. V. Pascoli, J. Terrier, C. Lüscher

P081. Alpha-lipoic acid reduces ethanol self-administration in rats. A.T. Peana, G. Muggironi, A. Arru, M. Diana

P082. Differential effects of addictive drugs on dopamine release in shell and core of the Nucleus Accumbens in Hatano high and low-avoidance rats. G Piras, V Perra, R Frau, GP Serra, V Valentini, G Di Chiara.

P083. A novel BAC transgenic mouse strain expressing GFP under control of the dopamine transporter promoter. Sara Stilling, Jacob Eriksen, Gunnar Sørensen, Troels Rahbek-Clemmensen, Jan Pravsgaard Christensen, Ulrik Gether  and Mattias Rickhag

P084. The role of rostromedial tegmental nucleus in the regulation of dopamine neurons in sardinian alcohol preferring rats. C. Sagheddu, M. De Felice, G. Colombo, M. Melis, M. Pistis

P085. Alterations in cached learning in alcoholism: pilot data. M. Sebold, M. Garbusow, N. Bernhard, C. Hägele, E. Friedel, C. Sommer, E. Jünger, A. Beck, A. Genauck, U. Zimmermann, M. Rapp, F. Schlagenhauf, M. Smolka, Q.J.M. Huys, A. Heinz

P086. Glutamatergic inputs to dopaminoceptive neurons affect novelty- seeking and sensitivity to alcohol. M. Sikora, M. Smutek, K. Lopata, J. Zajdel, R. Przewlocki, J.R. Parkitna

P087. The dopamine activating properties of ethanol - neurocircuitry involved. B. Söderpalm, S.Jonsson, R.Stomberg, L. Adermark, J. Morud, M. Ericson

P088. Contribution of ventral and dorsal striatal dopamine to the reinforcing properties of alcohol. M. Spoelder, H.M.B. Lesscher, L.J.M.J. Vanderschuren

P089. Implications for temporally precise optogenetic inhibition of reinstated cocaine seeking. M. Stefanik, P. Kalivas

 

                                    Topic: Dopamine and Reward

 

P090. Dissociating the rewarding and motivational properties of social play behavior in adolescent rats: the role of dopamine, opioids and endocannabinoids. E.J.M. Achterberg, L.W.M. van Kerkhof, M. Servadio, M. van Swieten, V.. Trezza, L.J.M.J. Vanderschuren

P091. Regulation of ethanol-induced dopamine release by inhibitory receptors in striatal subregions. L  Adermark*; R Clarke; B Söderpalm; M Ericson

P092. DREADD-regulated modulation of behaviour in TH-CRE rats by increased VTA dopamine neuron activity. L. Boekhoudt, G. van der Plasse, M.L. Luijendijk, R.A.H. Adan

P093. Anandamide interacts with the dopaminergic system to facilitate male rat sexual behaviour expression. A. Canseco-Alba, G. Rodríguez-Manzo

P094. Choosing between sucrose consumption or running on a wheel depends on dopamine in the motivational circuitry: Involvement of D2 and adenosine A2A receptors. M Correa*, M Pardo, L López-Cruz, P Bayarri, N SanMiguel, and JD Salamone

P095. Neurochemical and behavioural responsiveness during sucrose self-administration. F. Cucca, V. Bassareo, P. Musio, R. Frau, G. Di Chiara

P096. DNA methylation in the ventral tegmental area regulates associative reward learning. Jeremy J. Day, Daniel Childs, Mercy Kibe, Mikael Guzman-Karlsson, Jerome Moulden, Esther Song, & J. David Sweatt

P097. Working activity for palatable caloric or non caloric food in non food- deprived and food-deprived rats. De Montis MG,Scheggi S, Secci ME, Marchese G, Gambarana C

P098. Role of striatal indirect pathway dopamine D2 receptors in drug reward

L.K. Dobbs; V.A. Alvarez

P099.Conditioned saccharin avoidance induced by intra-accumbens shell amphetamine and intra-VTA morphine. Espa E., Fenu S., Cadoni C, Di Chiara G

P100. Spontaneous inhibitory synaptic currents mediated by D2 receptors. SC Gantz and JT Williams

P101. Mesolimbic dopamine transmission during choices involving cost-benefit tradeoffs. N.G. Hollon, M.M. Arnold, J.O. Gan, K.L. Reinelt, M.E. Walton, P.E.M. Phillips; N.G. Hollon

P102. The effect of LHb inactivation on Pavlovian versus Instrumental reversal learning. P. Jean-Richard dit Bressel & G.P. McNally; P. Jean-Richard dit Bressel

P103. Protein Kinase C β and the Dopamine Transporter Regulate Surface D2-Like Dopamine Receptor Localization. Kathryn Luderman1, Bipasha Guptaroy1, Prashant Donthamsetti2, Jonathan Javitch2, Paul R. Albert3, Margaret Gnegy1

P104. Role of nucleus accumbens dopamine in social play behavior in adolescent rats. Manduca, R. Damsteegt, P. Campolongo, V. Cuomo, L.J.M.J. Vanderschuren, V. Trezza

P105. Isoflavone administration reduces cocaine self-administration responses and cue-induced cocaine seeking behavior and relapse in mice. Miquel Martin, Roberto Cabrera, Rafael Maldonado, Marta Torrens, Rafael de la Torre, Magi Farré

P106. Inhibition of PKCbeta by enzastaurin attenuates amphetamine-stimulated efflux and behavior. SR Mikelman, OS Mabrouk, RT Kennedy, ME Gnegy

P107. Dopamine transmission and the role of D1- versus D2-like receptors in the nucleus accumbens during unexpected reward omission. Kirsten Porter-Stransky, Jillian Seiler, Omar Mabrouk, Robert Kennedy, Brandon Aragona

P108. Interactions between the Opioid and Dopamine System Regulate Pair Bond Formation and Maintenance in the Socially Monogamous Prairie Vole. Shanna L. Resendez, Caely Hambro, Morgan Kuehnmunch, Piper Keyes, Francis K. Maina, Tiffany A. Mathews, Brandon J. Aragona

P109. Real-time dopamine release to food-predictive Pavlovian cues in rats with a history of cocaine self-administration. Michael P Saddoris, Jonathan A Sugam, Regina M Carelli

P110. Effect of repeated administration of morphine and nicotine on 50-kHz ultrasonic vocalizations in male rats. Nicola Simola, Micaela Morelli

P111. Instrumental and Pavlovian conditioning in mice with inducible inactivation of NMDA receptors on cells expressing dopamine receptors D1. M. Smutek, M. Sikora, K. Tokarski, J. Zajdel, J. Rodriguez Parkitna, R. Przewlocki

P112. Optogenetic Modulation of Ventral Tegmental Area Dopaminergic and GABAergic Neurons Affects Cue-reward Seeking. Ruud van Zessen*, Geoffrey van der Plasse, Martin P. Smidt, Geert M. J. Ramakers, Garret D. Stuber, Roger A. H. Adan

P113. Neurosteroid agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons. Elena Vashchinkina, Aino Manner, Teemu Aitta-aho, Olga Vekovischeva, Mikko Uusi-Oukari, Esa R Korpi

 

 

 

 

 

 


 

Tuesday, MAY 28th

8:30 – 10:30                        SESSION 1

                                    Topic: DOPAMINE AND SCHIZOPHRENIA

 

Room: LAZZARETTO           HIPPOCAMPAL OVERDRIVE OF THE MESOSTRIATAL DOPAMINE SYSTEM AS A BASIS FOR PSYCHOSIS IN SCHIZOPHRENIA

Chair: A.A. Grace (USA) CoChair: F. Georges (France)

Organizer: A.A. Grace (USA)

D. Lodge (USA) Aberrant hippocampal regulation of dopamine system function in the MAM model of schizophrenia

O. Howes (UK) Striatal dopamine & hippocampal glutamate in the development of schizophrenia

A. AbiDargham (USA) Mapping the cortical and striatal response of the dopaminergic system to amphetamine: relationships to symptoms

E. Duezel (Germany) Functional imaging of the hippocampal-SN/VTA loop in humans

 

                                    Topic: DOPAMINE AND PARKINSON’S DISEASE

 

Room: ARCHI           DOPAMINE AND RESTLESS LEGS SYNDROME

Chair: W. Paulus (Germany) CoChair: D. Rye (USA)

Organizer: W. Paulus (Germany)

C. Trenkwalder (Germany) Treatment of the Restless Legs Syndrome (RLS)

W. Paulus (Germany) Dopaminergic Augmentation in RLS

D. Rye (USA) Functional Anatomy and Genetics Underlying Dopamine's Role in Restless Legs Syndrome

I. Ghorayeb (France) The non-human primate A11 diencephalospinal pathway is not dopaminergic

 

                                    Topic: DOPAMINE AND REWARD

 

Room: QUARTÉ           DUAL CONTROL OF DOPAMINE BY D2 AUTORECEPTORS AND DAT: REGULATION, EPISTASIS AND BEHAVIORAL IMPACT

Chair: M.E. Gnegy (USA) CoChair: E. Borrelli (USA)

Organizer: M.E. Gnegy (USA)

M. BenoitMarand (France) D2 autoreceptors stimulation enhances extracellular dopamine levels by acting synergistically on release and uptake mechanisms

E.M. Gnegy (France) Protein kinase Cβ modulates trafficking and function of the dopamine transporter and the dopamine D2 autoreceptor

A. Bertolino (Italy) Association of genetic and epigeneticvariation of dopamine genes with phenotypesrelated to risk for schizophrenia

W. Sadee (USA) Epistatic interactions between DRD2 and DAT genes: implications for clinical phenotypes

 

                                    Topic: DOPAMINE AND ADDICTION

 

Room: SAYÀL           NEUROPLASTICITY OF CORTICOLIMBIC DOPAMINE AND GLUTAMATE PATHWAYS IN DRUG ADDICTION

Chair: R.E. See (USA) CoChair: R. Spanagel (Germany)

Organizer: R. E.See (USA)

L. Vanderschuren (Netherlands) Striatal dopamine in compulsive drug use

R. Spanagel (Germany) mGluR2 loss in the corticoaccumbal neurocircuitry is a key pathophysiological mechanism mediating increased propensity to relapse

E. Valjent (France) Glutamatergic input from specific sources triggers psychostimulant-induced topographical and cell-type specific ERK activation in various nucleus accumbens shell subterritories

F. Fumagalli (Italy) Dynamic modulation of neuroplastic markers of dopaminergic and glutamatergic pathways following repeated exposure to cocaine during adolescence

R.E. See (USA) Methamphetamine-induced alterations in prefrontal cortex glutamate and dopamine function

 

                                   

 

 

 

 


 

Topic: DOPAMINE AND NEURODEGENERATION

 

Room: RISTORANTE           ALTERED ROLE OF DOPAMINE IN HUNTINGTON’S DISEASE

Chair: M.S. Levine (USA) CoChair: M. Parent (Canada)

Organizer: M.S. Levine (USA)

M. Parent (Canada) Dopamine and serotonin innervation of the human striatum : A comparison between Huntington's chorea and Parkinson's disease

K. Murphy (UK) Altered Dopaminergic Function in the R6/1 Mouse Model of Huntington's Disease

C. Cepeda (USA) Time-dependent alterations in dopamine modulation of glutamate synaptic transmission in mouse models of Huntington's disease

M. Johnson (USA) Dopamine release and uptake alterations in Huntington's disease model rodents

 

10:30 – 11:00            Coffee Break

11:00 – 13:00            SESSION 2

                                    Topic: DOPAMINE AND PARKINSON’S DISEASE

 

Room: LAZZARETTO           IMPULSIVITY IN PARKINSON’S DISEASE

Chair: B. Averbeck (USA) CoChair: V. Voon (UK)

Oranizer: B. Averbeck (USA)

B. Averbeck (USA) Impulsivity in Parkinson's disease

A. Djamshidian (UK) Jumping to conclusions in Parkinson's disease

V. Voon (UK) Impulse control disorders in Parkinson's disease

A. Lawrence (Canada) Impulse Control Problems in Parkinson's Disease: An Incentive Sensitization Account

J. Rowe (UK) New approaches to treatment for impulsivity in Parkinson’s Disease

 

                                    Topic: DOPAMINE AND ADDICTION

 

Room: SAYÀL           MODULATION OF DOPAMINE SYSTEM FUNCTION BY NUCLEAR RECEPTORS: FOCUS ON ADDICTION

Chair: S.R. Goldberg (USA) CoChair: M. Melis (Italy)

Organizer: R. Ciccocioppo (Italy)

F. Tronche (France) Glucocorticoid Receptors in dopaminoceptive neurons, key for the modulation of the dopamine system and stress-related behaviors

S. Goldberg (USA) Peroxisome Proliferator-activated nuclear receptor-alpha (PPAR-a): A novel taget for the development of anti-nicotine smoking Cessation Treatments

M. Pistis (Italy) Bidirectional control of nicotinic cholinergic function by PPAR-α in dopamine neurons

R. Ciccocioppo (Italy) Activation of PPARγ by pioglitazone reduces opioid reinforcement and opioid-induced activation of the mesolimbic dopamine system

 

                                    Topic: DOPAMINE AND PARKINSON’S DISEASE

 

Room: QUARTÉ           PARKINSON’S DISEASE: FROM CAUSES TO NEUROPROTECTION

Chair: M.J. Zigmond (USA) CoChair: M.F. Chesselet (USA)

Organizer: M.J. Zigmond (USA)

A. Abeliovich (USA) Altered regulation of αSynuclein expression as a key determinant of "sporadic" Parkinson's disease risk

L. Stefanis (Greece) Chaperone-Mediated Autophagy as a target for neuroprotection in Parkinson's Disease

M. Tansey (USA) Targeting inflammatory pathways to protect DA neurons in Parkinson's Disease

M.F. Chesselet (USA) Preclinical testing of neuroprotective strategies in Parkinson's disease

 

                                   

 

 

 

 

 

 

 


 

Topic: DOPAMINE AND AFFECTIVE DISORDERS

 

Room: RISTORANTE           ALTERING ADULT BRAIN FUNCTION: ENDURING EFFECTS OF EARLY‐LIFE STIMULANT EXPOSURE

Chair: H. Steiner (USA) CoChair: G. Hanson (USA)

Organizer: H. Steiner (USA)

B. Kosofsky (USA) Molecular Maladaptations Underlying Behavioral Deficits in Prenatal Cocaine Exposed Mice

D. McCarthy (USA) Morphological and molecular alterations associated with prenatal cocaine exposure in mice

H. Steiner (USA) Cocaine-like gene regulation by methylphenidate in the adolescent striatum: Potentiation by SSRI antidepressants

C. Bolanos (USA) Juvenile Administration of Concomitant Methylphenidate and Fluoxetine Alters Behavioral Reactivity to Reward- and Mood-related Stimuli and Disrupts Ventral Tegmental Area Gene Expression in Adulthood

 

                                    Topic: DOPAMINE AND SCHIZOPHRENIA

 

Room: ARCHI           FUNCTIONAL CORRELATES OF DOPAMINE RECEPTOR SIGNALLING

Chair : M. Caron (USA) CoChair: C. Missale (Italy)

Organizer: C. Missale (Italy)

S. Nakanishi (Japan) Dopamine-mediated neural plasticity in reward and aversive learning behaviors

C. Missale (Italy) D1 receptor signalling in basal ganglia function and dysfunctions

J.A. Girault (France) Signaling from dopamine receptors to the nucleus: striatal neurons epigenetics

M.G. Caron (USA) Consequences of Functionally Selective Signaling at the D2 Dopamine Receptor

 

13:00 – 15:00            Lunch Break

15:00 – 17:00            SESSION 3

                                    Topic: DOPAMINE AND PARKINSON’S DISEASE

 

Room: RISTORANTE           MRI AND PET INSIGHTS INTO PARKINSON'S DISEASE

Chair: P. Tuite (USA) CoChair: A. Dagher (Canada)

Organizer: P. Tuite (USA)

M.J. McKeown (Canada) Resting State fMRI and other MR approaches to Parkinson's

P. Tuite (USA) Novel MRI and MRS methods in Parkinson's disease

A. Dagher (Canada) Functional brain imaging insights into cognitive and motivational disorders in Parkinson's Disease

N. Bohnen (USA) New PET imaging insights: Cholinopathy and gait and postural dysfunction in Parkinson Disease

 

                                    Topic: DOPAMINE AND ADDICTION

 

Room: SAYÀL           THE DOPAMINE TRANSPORTER: NEW INSIGHTS INTO PSYCHOSTIMULANT ACTIONS AND THE RELATIONSHIP TO NEUROPSYCHIATRIC DISORDERS

Chair: A. Galli (USA) CoChair: G. Hasler (Switzerland)

Organizer: U. Gether (Denmark)

A. Yamamoto (USA) Membrane microdomain localization of the dopamine transporter

J. Sutcliffe (USA) De novo and inherited rare variants identified from exome sequecing impact the

dopamine transporter and its regulatory network.

 ‐S. Amara (USA) Direct activation of intracellular signaling pathways by amphetamines: a mechanism

for modulating neurotransmitter transporter function

U. Gether (Denmark) The dopamine transporter: new genetic mouse models and the relationship to psychostimulant addiction and neuropsychiatric disorders

 

                                   

 

 

 

 

 

Topic: IMAGING DOPAMINE

 

Room: LAZZARETTO           IMAGING AND THE ROLE OF DOPAMINE ACROSS ADDICTIONS : DIFFERENCES AND COMMONALITIES

Chair: N.D. Volkow (USA) CoChair: M. Diana (Italy)

Organizer: D. Martinez (USA)

D. Martinez (USA) Imaging and the role of dopamine across addictions: differences and commonalities

E. Forbes (USA) Neural Response to Monetary Reward in Alcohol Dependence and Cannabis Use: Developmental Findings                     

A. Beck (Germany) Imaging and the role of dopamine across addictions: differences and commonalities

R. Narendran (USA) Imaging dopamine in prefrontal cortex

 

                                    Topic: DOPAMINE NEURONS

 

Room: QUARTÉ           REGULATION OF VTA NEURONS BY OREXIN/HYPOCRETIN: MECHANISMS, CIRCUITS AND BEHAVIORS.

Chair: G. AstonJones (USA) Cochair: P.J. Kenny (USA)

Organizer: G. Aston‐Jones (USA)

S. Borgland (Canada) Hypocretin modulation of morphine-induced synaptic plasticity in the ventral tegmental area

S. Mahler (USA) Functions of VTA orexin, and orexin/glutamate interactions in reinstatement of cocaine seeking

C. Dayas (Australia) Evidence for drug-induced modulation of the hypothalamic orexin to VTA dopamine neuron pathway and relevance for relapse-like behavior

R. Espana (USA) Hypocretin/orexin regulation of dopamine signaling: implications for motivated behavior

G. McNally (Australia) Orexin/dynorphin neuronal contributions to reinstatement and extinction of alcohol seeking

 

                                    Topic: ANATOMY AND PHYSIOLOGY OF DOPAMINE SYSTEMS

 

Room: ARCHI           NEW MECHANISMS BY WHICH TRACE AMINE‐ASSOCIATED RECEPTORS MODULATE DOPAMINE NEURON ACTIVITY

Chair: D.K. Grandy (USA) CoChair: M.C. Hoener (Switzerland)

Organizer: D.K. Grandy (USA)

-D. K. Grandy (USA) In Vivo Studies Reveal Trace Amine-Associated Receptor 1 Mediates a Novel Interaction Between Methamphetamine and Bupropion

G.M. Miller (USA) Trace Amine Associated Receptor 1 (TAAR1) Signaling Differentially Regulates Dopamine and Norepinephrine Transporter Internalization

M.C. Hoener (Switzerland) Discovery and characterization of selective TAAR1 agonists as potential therapeutic drugs in the field of mental illness

R. Gainetdinov (Italy) Neurochemical mechanisms involved in the modulation of dopamine transmission by Trace Amine Associated Receptor 1 (TAAR1)

 

17:00 – 17:30            Coffee Break

17:30 – 18:30            PLENARY LECTURE

Room: SAYÀL            Howard Fields (USA) How Opioids Control Midbrain Dopamine                 Neurons and Contribute to Reward

 

 

 

 

 

 

18:30 – 20:00            POSTER SESSION III

                                    Topic: Dopamine and Signal Transduction

 

P114. Combining DA application and time resolved FRET to investigate effects of physiological DA fluctuations on downstream signaling cascades in medium spiny neurons. Thorvald Andreassen, Kenneth Lindegaard Madsen, Ulrik Gether

P115. Growth Associated Protein-43 Regulates Dopamine Transporter Mediated Amphetamine-induced Reverse Transport. Bipasha Guptaroy, Aalisha Desai, Katharyn Luderman, Karina Meiri and Margaret E. Gnegy

P116. Erk1 map kinase regulates erk2 dependent signalling in the striatum. Marzia Indrigo, Daniel Orellana, Kerrie L. Thomas, Aura Frizzati, Raffaele d'Isa, Elena Marchisella, Riccardo Parra, Gianmichele Ratto, Stefania Fasano and Riccardo Brambilla

P117. SorCS2 is critical for dopaminergic firing pattern and the response to drugs of abuse. D. Olsen, S. Glerup, I. d. Jong, F. Sotty, J. Egebjerg, A. Nykjær

P118. Modulation of translational machinery in the striatum by d-amphetamine. Puighermanal E*, Biever A*, Gangarossa G, Valjent E

P119. Therapeutic approaches against Ras-ERK signaling for the treatment of L-DOPA induced dyskinesia and drug addiction. Nicola Solari, Francesca Marchisella, Livia Marrone, Alessandro Papale, Marzia Indrigo, Stefania Fasano and Riccardo Brambilla

 

                                    Topic: Dopamine and Schizophrenia

 

P120. Dysfunction in metabolic mTORC2/Akt signaling disrupts brain D2R signaling and DA homeostasis. Olga Dadalko, Michael Siuta, Amanda Poe, Roxanne A. Vaughn, Kevin Niswender, Aurelio Galli

P121. Antipsychotic-like properties of antiandrogenic drugs: focus on dopaminergic system. Roberto Frau, Valentina Bini, Paola Devoto, Marco Bortolato

P122. Intranasal Oxytocin effects in mice. Huiping Huang, Caterina Michetti, Marta Busnelli, Luca Giancardo, Francesca Managò, Sara Sannino, Diego Scheggia, Diego Sona, Vittorio Murino, Bice Chini, MariaLuisa Scattoni, Francesco Papaleo

P123. D-cell hypothesis for mesolimbic dopamine hyperactivity of schizophrenia. Keiko Ikemoto

P124. Specific knockdown of the Drd2 gene in the NAcc reproduces the social novelty discrimination deficit induced by a neonatal treatment with phencyclidine. M. Ingallinesi, L. Le Bouil, N. Faucon Biguet, C. Mallet, C. Sauty, Ph. Ravassard, J. Mallet and R. Meloni

P125. Cariprazine preferentially induces c-fos mRNA in prefrontal cortical regions of rat brain: comparison with aripiprazole, SV-156 and SB-277011. B. Kiss, B. Pinter-Kubler, Sz. Ferenczi, K. Kovacs

P126. Cathecol-O-methyltransferase (COMT) modulates long-term memory in mice. Mereu M, Scheggia D, Papaleo F

P127. Arc involvement in Schizophrenia-related symptoms in mice. F. Managò; S. Sannino; R. Gainetdinov; K. Wang; F. Papaleo

P128. Dopamine and Other Monoamines Systems are Affected by Histamine(H3) Mechanisms: Combined Microdialysis and Electrophysiological Approaches. A.C. McCreary, E. Dremencov, G. Flik, J. H. A. Folgering, T. I. F. H. Cremers, B. H. C. Westerink.

P129. Midbrain dopamine neuron dysfunction in an infection-based rat model of schizophrenia: interaction with adolescent Cannabis exposure. L. Muntoni, A. Luchicchi, S. Lecca, M. De Felice, M. Melis, M. Scherma, P. Fadda, M. Pistis

P130. Pathophysiological alterations of midbrain dopaminergic neurons in their unit activity and channel properties in a schizophrenia model established by epidermal growth factor. Hisaaki Namba, Hiroyuki Nawa

P131. Modulation of dopaminergic signalling in the striatum by phosphodiesterase 10A (PDE10A) inhibitors. J. Nielsen, B. Steiniger-Brach

P132. Perinatal exposure to the cytokine EGF produces pallidal hyperinnervation of dopaminergic neurons and the indirect pathway dysfunction in the schizophrenia animal model. Hidekazu Sotoyama, Hisaaki Namba, Hiroyuki Nawa

 

                                    Topic: Dopamine Receptors

 

P133. Testing drugs for structural plasticity in dopaminergic neurons: translation from mouse primary cell culture to human iPSC-derived neurons. Bono F., Cavalleri L., Gennarelli M., Merlo Pich E. , Rubin L., Spano PF., Missale, C., Collo G.

P134. Striatal D2 receptors in stress coping: genetic and environmental influences. Simona Cabib, Paolo Campus, Valentina Colelli

P135. Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex. S.W. Centanni, H. Trantham-Davidson, J.T. Gass1, M.F. Lopez, P.J. Mulholland, S.B. Floresco and L.J. Chandler

P136. Distinct roles of dopamine D2 receptors in dorsal and ventral striatum on motor and drug-related behaviors. A. R. Kaplan, T. Doyle, E. Casey, R. B. Free, D. R. Sibley, M. Rubinstein, V. A. Alvarez

P137. Normalizing Dopamine D2 Receptor-Mediated Responses in D2-KO Mice by Virus-Mediated Restoration of D2 Receptors: Comparing D2L and D2S. K. Neve, D. Buck, C. Ford, J. Williams, R. Neve, T. Phillips

P138. Role of D1 and D3 dopamine receptor heterodimerization in the regulation of the receptor signaling. P. Tallarico*, R. Kumar, C. Busi, C. Fiorentini, PF. Spano and C. Missale

 

Topic: Dopamine and Affective Disorders

 

P139. Different classess of antidepressants increase dopamine and norepinephrine release in the bed nucleus of stria terminalis: an "in vivo" microdialysis study. Carboni Ezio, Ibba Marcello, Roberto Cadeddu

P140. The role of extended amygdala dopamine D2 receptor-expressing neurons in fear expression and fear generalization. De Bundel D, Espallergues J, Valjent E

P141. Molecular mechanisms behind inflammation-induced malaise and aversion. M. Fritz, A. Klawonn, D. Björk Wilhelms, M. Lazarus, U. Örtegren, M. Jaarola, J. R. Parkitna, C. B. Saper, A. Blomqvist, D. Engblom

P142. Initial pharmacotherapy by dopamine stabilizer, aripiprazole, for inpatients due to suicidal attempt. K Ikemoto, R Murao, R Ishiyama, K Sakamoto, M Hirai, I Fujimoto, K Iwai, A Koyama

P143. Tyrosine hydroxylase dysfunction and dopamine deficiency in phenylketonuria. Aurora Martinez, Tanja Scherer, Christineh N. Sarkissian, Ming Ying, Cary Harding and Beat Thöny

P144. Lateral Habenula Modulation Of Ventral Tegmental Area Dopamine Neurons in a Rodent Model of Depression. Jared L. Moreines and Anthony A. Grace

P145. The impact of co-treatment with antidepressant drugs and risperidone on the extracellular level of dopamine and its metabolites in rat frontal cortex. Zofia Rogóż, Katarzyna Kamińska, Krystyna Gołembiowska

 

                                    Topic: Dopamine Neurons

 

P146. Dopamine neurons in opiate withdrawal: a computational perspective. Fabio Caboni, Michele Migliore , Giovanna Mulas, Francesca Piras, Saturnino Spiga, and Marco Diana

P147. Functional and topographical analysis of the brainstem cholinergic innervation of the ventral tegmental area. Daniel Dautan, Albert Souza, Ilana Witten, Karl Deisseroth, J. Paul Bolam, Todor Gerdjikov and Juan Mena-Segovia

P148. Neural bases for the excitatory control of VTA dopamine neurons by the ventral hippocampus. Christelle Glangetas, Delphine Girard, Giulia R.Fois, Marion Jalabert, Laurent Groc, François Georges

P149. SorLA Controls Neurotrophic Activity by Sorting of GDNF and its Receptors GFRa1 and RET. S. Glerup, M. Lume, D. Olsen, M. Saarma, A. Nykjaer, and C.M. Petersen

P150. High throughput single-cell expression analysis of midbrain dopamine neurons reveals Aldh1a1 as marker of vulnerability in a model of Parkinson's disease. JF Poulin, J Zou, J Drouin-Ouellet, F Cicchetti, RB Awatramani

P151. Metabolic state affects the encoding of reward-related information by VTA dopamine neurons. G. van der Plasse*, R. van Zessen, M.C.M. Luijendijk, H. Erkan, G. D. Stuber, G.M.J. Ramakers, R. A. H. Adan

P152. Alpha-synuclein regulates dopaminergic synapse arrangement and functionality by modulating synapsin III and the dopamine transporter. M. Zaltieri, J. Grigoletto, L. Navarria, C. Missale, PF. Spano and A. Bellucci

 

                                   

Topic: Dopamine and Neuroplasticity

 

P153. Characterization Of Neural Activity Of Midbrain Dopamine And Rostromedial Tegmental Neurons In A Rat Model Of Neuropathic Pain.Aroni S., Sagheddu C., De Felice M., Lecca S., Luchicchi A., Muntoni A.L. and Pistis M.

P154. Cellular mechanisms underlying changes in eCB-signaling during the switch from the goal-directed to habitual behaviour. B. Greco, A. Rocchi, M. Trusel, PP. Saintot, M. Pennuto, R.Tonini

P155. An increase in the natural GDNF expression enhances and protects the nigrostriatal dopaminergic system. J Kopra, JO Andressoo, C Amberg, J Mijatovic, N Pulkkinen, TP Piepponen, M Saarma

P156. Lateral habenula neurons encoding aversion. S Lecca and M Mameli

P157. Transcription factors Lmx1a and Lmx1b cooperatively regulate axon guidance of midbrain dopamine neurons. A. Chabrat, E. Metzakopian, SL. Ang, M. Lévesque

P158. Acetaldehyde modulates dendritic spines in the Nucleus Accumbens after chronic treatment. G. Muggironi, G. Mulas, G.R. Fois, A.T. Peana, S. Spiga, M. Diana

P159. Toward a calcium-based account of dopamine-dependent STDP. David A. Peterson; Terrence J. Sejnowski

P160. Structural plasticity changes in the shell of the Nucleus Accumbens of ethanol dependent rats. Spiga S., Peana A.T., Mulas G., Fois G.R., Muggironi G., Cannizzaro C. Diana M.

P161. Dopamine Induces Gap-Junctions-Mediated Anti-Synchronous Action Potential Firing in Striatal Fast-Spiking Interneurons. G. Russo, T. Nieus, S. Taverna

P162. Endocannabinoid / dopamine interact to mediate bidirectional spike-timing dependent potentiation and depression. Hao Xu, Yihui Cui, Bruno Delord, Stephane Genet, Elodie Fino, Hugues Berry, Laurent Venance

P163. Calcium-impermeable, GluN3A-containing NMDARs in cocaine evoked synaptic plasticity. Yuan T, Mameli M., Verpelli C., Sala C., Luscher C., Bellone C.