Research Topic

Challenges in Biomarker Discovery for the Detection of Atherosclerosis

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About this Research Topic

Over the last years the use of biomarkers for diagnosis and risk prediction has become common practice e.g. in acute coronary syndrome and heart failure (troponins, NT-proBNP). However, they only reflect some aspects of the big picture. In basic research, markers of endothelial stress such as adhesion molecules and microparticles have been in the focus of researchers. However, in the clinical setting, detection of atherosclerosis and risk assessment in patients is still remaining challenging. Some marker proteins have been investigated already, such as fetuin-A as a marker for calcification. Though, due to challenges in laboratory analytical methods and multiple influencing factors (e.g. diabetes, renal function), the clinical use has been hindered so far.

Further research in this field seems warranted to define new markers reflecting additional pathophysiologic pathways. Starting points for such an endeavor would be endothelial function, microparticles, lipid metabolism, adhesion molecules, and inflammatory cells. Apart from traditional protein markers, also additional methodological approaches, e.g. proteomics, metabolomics, and lipidomics would be of interest. In addition, also the development of molecular imaging methods to identify subclinical atherosclerotic lesions or to monitor changes in clinical trials would be of interest. Data from such analysis could be used to identify high-risk patients, define individualized treatments and focus prevention strategies.

In this Research Topic, we seek to provide an overview of the current developments in the field of biomarker research for atherosclerosis, ranging from molecular pathways, cellular communication up to the development and clinical use of biomarkers. We request the submission of both basic science studies that investigate pathways or proteins that could be of interest for biomarker development or clinical trials that assessed markers in a clinical setting (e.g. for diagnosis or risk prediction). Moreover, papers focusing on a translational approach are of particular interest, and submissions of review articles and methodology papers are also welcome.


Keywords: Biomarkers, Athersclerosis, Vascular/Endothelial Stress, Risk Prediction


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Over the last years the use of biomarkers for diagnosis and risk prediction has become common practice e.g. in acute coronary syndrome and heart failure (troponins, NT-proBNP). However, they only reflect some aspects of the big picture. In basic research, markers of endothelial stress such as adhesion molecules and microparticles have been in the focus of researchers. However, in the clinical setting, detection of atherosclerosis and risk assessment in patients is still remaining challenging. Some marker proteins have been investigated already, such as fetuin-A as a marker for calcification. Though, due to challenges in laboratory analytical methods and multiple influencing factors (e.g. diabetes, renal function), the clinical use has been hindered so far.

Further research in this field seems warranted to define new markers reflecting additional pathophysiologic pathways. Starting points for such an endeavor would be endothelial function, microparticles, lipid metabolism, adhesion molecules, and inflammatory cells. Apart from traditional protein markers, also additional methodological approaches, e.g. proteomics, metabolomics, and lipidomics would be of interest. In addition, also the development of molecular imaging methods to identify subclinical atherosclerotic lesions or to monitor changes in clinical trials would be of interest. Data from such analysis could be used to identify high-risk patients, define individualized treatments and focus prevention strategies.

In this Research Topic, we seek to provide an overview of the current developments in the field of biomarker research for atherosclerosis, ranging from molecular pathways, cellular communication up to the development and clinical use of biomarkers. We request the submission of both basic science studies that investigate pathways or proteins that could be of interest for biomarker development or clinical trials that assessed markers in a clinical setting (e.g. for diagnosis or risk prediction). Moreover, papers focusing on a translational approach are of particular interest, and submissions of review articles and methodology papers are also welcome.


Keywords: Biomarkers, Athersclerosis, Vascular/Endothelial Stress, Risk Prediction


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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