About this Research Topic
Alzheimer’s, Parkinson’s and Huntington’s disease are this century’s most common Neurodegenerative Diseases (NDs) affecting the elderly population. These devastating neurodegenerative diseases are associated with progressive brain cell loss, and other deleterious processes leading to a number of different symptoms, affecting the daily independent life of patients. These NDs cause a huge economic burden, and stress on caregivers and family members, representing an unprecedented global public health challenge. With so far only ameliorating treatments available, further research into developing novel and effective disease-modifying therapies is becoming more crucial. As such, the discovery of new causative agents involved in the onset and progression of these neurodegenerative disorders is necessary to identify new therapeutic approaches.
One of such targets could be glycans, which are carbohydrates attached to proteins. The glycan compositions at proteins play major metabolic, structural, and physical roles in all biological systems. Specifically, in neurodegenerative diseases, they have gained increasing attention to further the understanding of disease progression as well as potential biomarkers for early disease detection. The particular aberrant protein glycosylations and consequently changes to the glycome are unique for each neurodegenerative disease. These unique signatures can be beneficial for subtyping such diseases and providing new insights into pathomechanisms. This research has gained recent attention through several studies investigating the glycoproteomics.
In this Research Topic, we aim at Research Articles and Reviews that focus on the role of glycans in neurodegenerative diseases. This includes both translational strategies in order to identify new biomarkers as well as understanding the diverse glycan biology and its role in the onset and the progression of the pathology.
Keywords: Glycans, neurodegeneration, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, proteomics
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