Research Topic

Novel Insights from Molecular Mechanism to Therapeutic Approaches

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About this Research Topic

This Research Topic collaborates with the 2019 Gordon Research Conference on Atherosclerosis which will be organized between 16-21 June 2019 and will serve as a kick off to open for contributions from across the field. ...

This Research Topic collaborates with the 2019 Gordon Research Conference on Atherosclerosis which will be organized between 16-21 June 2019 and will serve as a kick off to open for contributions from across the field.

Atherosclerosis underlies the leading cause of death in industrialized societies. During atherogenesis, the accumulation of apolipoprotein B-containing lipoproteins (LDL and VLDL) in the matrix beneath the endothelial layer of blood vessels leads to the recruitment of monocytes, the cells of the immune system that give rise to macrophages and dendritic cell. Macrophages derived from these recruited monocytes participate in a maladaptive, non-resolving, inflammatory response that expands the subendothelial layer due to the accumulation of cells, lipids, and matrix. Despite advances in the prevention and management of cardiovascular disease (CVD), this multifactorial disorder remains a leading cause of mortality worldwide. Therefore, it is crucial to understand not only the pathophysiology of atherosclerosis but also the mechanistic insights of how each factor such as dyslipidemia, inflammation and vascular remodeling contribute to the development of this disease.

This Research Topic provides a comprehensive overview of the current dogmas about atherosclerotic disease progression, how to utilize new high dimensional methods to study cellular and molecular components of the atherosclerotic plaque, and identify and discuss new clinical targets, with the goals to treat, and ultimately prevent, atherosclerosis. The topic editors’ welcome various types of articles, including original research, review articles, methodology articles, and other article types.


Keywords: Atherosclerosis, Inflammation, Dyslipidemia, Clinical Targets, Prevention


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