Research Topic

Genetics Architecture and Underlying Molecular Mechanisms in Host-Pathogen Interactions

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About this Research Topic

Dynamic host-pathogen interactions determine the outcome of infections, clinical sequelae and the success of prophylactic or therapeutic treatments. The use of a wide variety of molecular and cell biology tools such as advanced microscopy, -omics techniques, as well as data analysis capacities facilitated by ...

Dynamic host-pathogen interactions determine the outcome of infections, clinical sequelae and the success of prophylactic or therapeutic treatments. The use of a wide variety of molecular and cell biology tools such as advanced microscopy, -omics techniques, as well as data analysis capacities facilitated by advanced statistical and machine learning algorithms have increased our understanding in host-pathogen interactions. However, the explicit underlying molecular mechanisms remain elusive or unexplored. This has restrained the development of novel disease intervention strategies. The identification of host genes and key pathogen-interacting factors by a genome-wide genetic expression, epigenetic profiling, and other emerging technologies as well as the dissection of the role of microbiome composition should provide important insights to combating infectious diseases.

This Research Topic aims to present state-of-the-art research and future directions for host-pathogen interactions. Specifically, we encourage the submission of reviews, original research, and method articles, as well as perspective articles, in the following (but not limited to) topics:

• Host genetic variation (structural variants, CNVs, and SNPs) that conditions the outcome of pathogen (such as virus, bacteria, etc.) infections
• Host functional genomics studies (transcriptomic, proteomic, epigenetic, etc.) that shed light into the mechanisms shaping infection processes
• Host microbiome composition and its effect on the pathogen load
• Systems biology approaches integrating the “omics” of infection and host responses
• Utilization of cellular systems, animal models, or single cell analyses to interrogate host genetic control of pathogenesis
• Genetic factors that control innate and adaptive immune responses to pathogens
• Genetic and epigenetic factors that affect host immune response to vaccine and treatments


Keywords: Host-pathogen interactions, "omics" and systems biology, genetics, epigenetics, one health


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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