About this Research Topic
The detrimental effects of obesity on cardiovascular health are well documented. The Center for Disease Control ranks heart disease as the leading cause of death in the world. People with metabolic syndrome are twice as likely to suffer a heart attack and five-fold more likely to develop type 2 diabetes. Moreover, according to the International Diabetes Federation, 25% of the world's adult population has metabolic syndrome. As such, there is a clear need to better understand and treat obesity, metabolic diseases, and related cardiovascular comorbidities.
Although we understand that there are central nervous system implications with many metabolic conditions, we do not have a full understanding of the central signaling mechanisms involved in blood pressure and metabolism. Importantly, we also do not fully understand the implications of aberrant neural activity on the progression of cardiovascular-related diseases. For example, obesity not only increases the risk of myocardial infarct, but by virtue of obesity-induced changes in central neural signaling. it is also likely to augment myocardial injury when it does occur. Although several physiological mechanisms such as salt balance, renal function, and vascular disorders may contribute to the pathogenesis of hypertension, it is generally agreed that a hallmark of neurogenic hypertension is increased reliance on increased sympathetic activity.
In this Research Topic, we welcome original articles and review papers that highlight the most recent findings on the central autonomic pathways, cellular and molecular and neurophysiological mechanisms, and potential treatments in metabolic-related neurogenic hypertension.
Keywords: Sympathetic, blood pressure, hypertension, obesity, metabolic syndrome
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