About this Research Topic
Biofilms are highly organized, surface-attached, spatially-oriented communities of densely packed microbes, embedded in a biopolymeric matrix (Extracellular Polymeric Substance or EPS). Dysbiosis of the dental plaque biofilm is the main cause of the most common oral diseases that affect mankind, namely, dental caries and periodontal (gum) disease. The treatment of biofilm-mediated infections has been classified as a clinical super-challenge, based on the fact that drug development has not met the rapid emergence of multidrug-resistant bacteria. Biofilm-mediated oral diseases, including dental caries, root canal infections, and periodontitis, pose important public health challenges due to their prevalence and impact on systemic diseases. Oral biofilms typically include a mixture of Gram-positive and Gram-negative organisms, as well as facultative and obligate anaerobic bacteria. Over the past few decades, the interest in biofilms research has multiplied exponentially. With this increasing knowledge, the idea of what is unknown is also very clear. Analysis of microbiomes, biofilm formation, environmental cues or interactive profiles that could create biofilm dysbiosis and virulence, polymicrobial interactions, antimicrobial resistance, persister cells, host-pathogen interactions and novel therapeutic strategies to eliminate or modulate biofilms are key research topics in this regard.
In this Research Topic, we seek Reviews, Perspectives and Original Research articles on cutting-edge research that would help us advance oral biofilm research.
The topics of interest include, but are not limited to:
• Characterization of biofilms
• Quorum-sensing and virulence
• Development of biofilm models for research
• Cross-talk between microbes
• Biofilm modulation
• Novel therapeutic strategies
Keywords: Biofilm, Virulence, Quorum-sensing, EPS matrix, Cross-talk
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.