About this Research Topic
Although it has been more than 50 years since the first article on Kawasaki disease (KD) was written by Dr. Tomisaku Kawasaki, the persuasive cause of this disease and its coronary artery complication is still unknown.
The epidemiology of KD provides important data for each country. Researchers are trying to elucidate specific cytokines and pathogenic factors from various viewpoints of intrinsic disposition. Their effort has discovered approximately 30 genetic variants related to the disease’s susceptibility, the resistance to immunoglobulin treatment, or coronary artery complications. In addition, the extrinsic factors, such as pathogens, or natural factors including weather, may play essential roles in the epidemiology of KD.
We would like to publish studies which suggest clinically feasible biomarkers for accurate diagnosis of KD, especially incomplete Kawasaki disease.
Long-term prognosis of cardiac sequela is another important issue. This will be addressed by discussing the impact of genetic predisposition and acute treatment on the regression or progression of coronary artery aneurysms.
Original articles, including case reports, from multidisciplinary fields such as epidemiology, pathology, genetics, infectious disease, rheumatology, immunology, hematology, cardiology, and intensive care are welcome in this topic. We would particularly like to include articles on following themes:
• Epidemiology; Current trends globally as well as larger case series of specific subgroups, such as KD schock syndrome.
• Genetics: Novel gene variants which are specific to KD and disclose their actions.
• Biomarkers: Surrogate markers to diagnose KD when typical physical signs are not fulfilled
• Therapies: Strategies to treat refractory KD cases and long term sequelae of KD, including coronary artery damage and heart failure.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.