Linking Treatment Target Identification to Biological Mechanisms Underlying Mood Disorders

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Zhejiang University

Columbia University

Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University

The University of Melbourne

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Mood disorders, such as major depressive disorder and bipolar disorder, are associated with persistently high rates of morbidity and mortality. Consequently, mood disorders are the leading cause of disability worldwide. However, the pathophysiology of mood disorders remains poorly understood. An improved understanding of their pathophysiology is of importance for the discovery of novel targets which may yield better outcomes in the treatment of mood disorders. Accumulating evidence suggests that immune system dysregulation represents an important vulnerability factor for mood disorders. Other novel biological research highlights new receptors, the microbiota-gut-brain axis and PUFAs as additional potential underlying factors.

In this Research Topic, we seek to highlight studies that focus on (i) novel psychotropic drug treatment targets for mood disorders and (ii) how they are linked to the search for novel therapeutics for mood disorders. The mechanisms, efficacy, and safety of these treatment strategies need to be verified in future studies.

We welcome original research articles, review articles, as well as clinical trials to focus on the following scopes, but not limited to:

• Neuro-immune regulatory dysfunction related to mood disorders
• Treatment targeting microbiota in mood disorders
• New clinical research into the therapeutic mechanisms of mood stabilizers and antipsychotics in mood disorders
• Clinical translational research on the action of probiotics and prebiotics in mood disorders
• Novel modifiers of lipid profile to enhance anti-inflammatory effect.
• Other anti-inflammatory treatment studies in mood disorders.

Mood disorders, such as major depressive disorder and bipolar disorder, are associated with persistently high rates of morbidity and mortality. Consequently, mood disorders are the leading cause of disability worldwide. However, the pathophysiology of mood disorders remains poorly understood. An improved understanding of their pathophysiology is of importance for the discovery of novel targets which may yield better outcomes in the treatment of mood disorders. Accumulating evidence suggests that immune system dysregulation represents an important vulnerability factor for mood disorders. Other novel biological research highlights new receptors, the microbiota-gut-brain axis and PUFAs as additional potential underlying factors.

In this Research Topic, we seek to highlight studies that focus on (i) novel psychotropic drug treatment targets for mood disorders and (ii) how they are linked to the search for novel therapeutics for mood disorders. The mechanisms, efficacy, and safety of these treatment strategies need to be verified in future studies.

We welcome original research articles, review articles, as well as clinical trials to focus on the following scopes, but not limited to:

• Neuro-immune regulatory dysfunction related to mood disorders
• Treatment targeting microbiota in mood disorders
• New clinical research into the therapeutic mechanisms of mood stabilizers and antipsychotics in mood disorders
• Clinical translational research on the action of probiotics and prebiotics in mood disorders
• Novel modifiers of lipid profile to enhance anti-inflammatory effect.
• Other anti-inflammatory treatment studies in mood disorders.

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Editors

Zhejiang University

Columbia University

Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University

The University of Melbourne

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Frontiers in Psychiatry

Mood Disorders, Molecular Psychiatry, Psychological Therapy and Psychosomatics

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