Research Topic

Monitoring Immune Responses in Renal Autoimmune and Autoinflammatory Diseases

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About this Research Topic

The search for novel treatment options in renal autoimmune diseases almost simultaneously requires the need for new immunomonitoring tools. Monitoring relevant immune responses in patients with renal autoimmune diseases helps us to better understand a) the underpinning immunological pathophysiology of these ...

The search for novel treatment options in renal autoimmune diseases almost simultaneously requires the need for new immunomonitoring tools. Monitoring relevant immune responses in patients with renal autoimmune diseases helps us to better understand a) the underpinning immunological pathophysiology of these diseases and b) the beneficial effects of novel treatments on autoimmunity. Immunomonitoring includes a wide range of approaches to monitoring immune responses by the cellular immune system (e.g. T-cells, B-cells, plasma cells, dendritic cells, neutrophils, etc.) or by the humoral immune system (e.g. cytokines, (auto-)antibodies, urinary markers, etc.). In addition, immunomonitoring can potentially help doctors and patients when choosing a personalized treatment strategy, define response to treatment on a clinical as well as an immunological level, and predict prognosis of the disease.

Exemplary in this research field are novel B-cell and ANCA immunomonitoring in ANCA associated vasculitis in relation to treatment, histopathological determinants of renal biopsies in anti-GBM disease and IgA nephropathy. Many novel biomarkers are explored in different renal autoimmune diseases, such as IgG4 RNA signatures in AAV, neutrophil extracellular trap formation and degradation in lupus nephritis or complement factors in IgA nephropathy.

To foster knowledge and discussion on investigating and monitoring relevant immune phenomena in patients with renal autoimmune diseases, the present Research Topic aims to increase our understanding, in a broad sense, of relevant pathological mechanisms underpinning renal autoimmune diseases. In this way, we hope to also stimulate advances in urgently needed novel therapeutic strategies for renal autoimmune diseases.

We welcome the submission of Review, Mini-Review and Original Research articles covering the following renal autoimmune diseases:

1. ANCA associated vasculitis.
2. Lupus nephritis.
3. IgA nephropathy.
4. Membranoproliferative glomerulonephritis (MPGN) both immune-complex mediated (e.g. cryoglobulinemia-associated MPGN) and non-immune complex-mediated (e.g. C3 glomerulopathy, aHUS-related nephropathies).
5. Anti-GBM disease.
6. Membranous nephropathy.
7. Renal involvement in systemic autoimmune diseases (e.g. Sjogren’s disease, polyarteritis nodosa, sarcoidosis, systemic sclerosis/scleroderma).


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