Research Topic

The ventricular-subventricular zone: a source of oligodendrocytes in the adult brain

About this Research Topic

Demyelinating diseases are characterized by an extensive loss of oligodendrocytes and myelin sheaths from axolemma, which commonly result in disability in young adults. To date, there is no effective treatment against these neurological disorders. In the adult brain, there are neural stem cells (NSCs) that ...

Demyelinating diseases are characterized by an extensive loss of oligodendrocytes and myelin sheaths from axolemma, which commonly result in disability in young adults. To date, there is no effective treatment against these neurological disorders. In the adult brain, there are neural stem cells (NSCs) that reside within a niche denominated ventricular-subventricular zone (V-SVZ) in the lateral wall of the cerebral ventricles. NSCs give rise to neurons and oligodendrocytes that help preserve cellular homeostasis. Growing evidence indicates that V-SVZ progenitor cells may represent an endogenous source of oligodendrocytes that can be useful to treat demyelinating diseases. For this topic, Frontiers in Cellular Neuroscience is accepting paper proposals for the Research Topic “The ventricular-subventricular zone as a source of oligodendrocytes in the adult brain”, which is aimed to collect the most recent evidence regarding the mechanisms that modulate the proliferation, migration, quiescence, cell-fate choices and survival of oligodendrocyte precursors generated in the V-SVZ. Herein we welcome novel research findings, short communications, full-length original research, review articles, hypotheses and methodological articles in the field of oligodendrocyte generation, oligodendroglial expansion, myelin production and white matter re-myelination upon manipulation of adult neural stem cells. The potential topics and techniques include, but are not limited to:

• Derivation, characterization and differentiation of neural stem cells
• Molecular biology techniques (Polymerase chain reaction, DNA microarrays, expression cloning, etc.)
• Gene delivery approaches
• Stem cell transplantation for white matter repair
• Imaging techniques
• Cell banking
• Cell tracking
• Cell delivery vehicles
• Therapeutic potential of V-SVZ oligodendrocyte precursors for remyelination
• Translational pre-clinical studies (animal models in-vivo or in-vitro experiments)
• Tissue engineering and biomaterials for white matter repair
• Applications for cell-based strategies in demyelinating diseases


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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