Research Topic

Recent Application of Nanomaterials in Sample Preparation

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About this Research Topic

A typical analytical process consists of sample collection, sample preparation, detection and data processing. It’s proven sample preparation takes up to 70% of the entire analytical time, and is vital to make samples compatible with the following detection step by extracting/preconcentrating target analytes from sample matrices. The final result is significantly affected by this step, especially when dealing with trace target analytes in complicated samples, such as biofluids, tissues, etc. Sample preparation determines the throughput, sensitivity and stability of the whole analytical process. Nanomaterials possess ultrahigh specific areas and increasing surface activities, and thus are ideal materials to cope with the demands of high throughput analysis of trace compounds in complicated samples. Moreover, their flexibility to be functionalized with various chemical groups could increase their affinity toward various analytes and samples.

Nowadays, various nanomaterials have been introduced for sample preparation, including metallic nanoparticles, metal organic frameworks materials, carbon nanomaterials and silica-based nanoparticles. Their applications include the areas of food sciences, environmental, pharmaceutical, biological and medical analysis. Sample preparation throughput, purification performance, or sensitivity were improved by the utilization of the nanomaterials at some extent. However, the current forms of most nanomaterials are not available at an affordable cost, and the implementation of nanomaterials in sample preparation is far from efficient in routine analysis. Thus we aim to explore easy and economical synthetic methods of nanomaterial-based sorbents, the innovation on their surface chemistry modification for selective extraction, and how to make use of the superior properties of nanomaterials and expand their application to more demanding analytical tasks.

Subjects covered in this Research Topic include, but are not limited to, the following:

• Synthesis and design of new nanomaterials.
• Modification of nanomaterials with novel functional moieties.
• Integration of nanomaterials with new extraction modes.
• Investigation of extraction mechanism of new nanomaterials.
• Application of nanomaterials for challenging samples analysis, such as single cell analysis, biomarker exploration, metabolomics, and proteomics.
• Coupling of nanomaterial with other analytical strategies, such as multidimensional analysis, chemical derivatization, etc.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

A typical analytical process consists of sample collection, sample preparation, detection and data processing. It’s proven sample preparation takes up to 70% of the entire analytical time, and is vital to make samples compatible with the following detection step by extracting/preconcentrating target analytes from sample matrices. The final result is significantly affected by this step, especially when dealing with trace target analytes in complicated samples, such as biofluids, tissues, etc. Sample preparation determines the throughput, sensitivity and stability of the whole analytical process. Nanomaterials possess ultrahigh specific areas and increasing surface activities, and thus are ideal materials to cope with the demands of high throughput analysis of trace compounds in complicated samples. Moreover, their flexibility to be functionalized with various chemical groups could increase their affinity toward various analytes and samples.

Nowadays, various nanomaterials have been introduced for sample preparation, including metallic nanoparticles, metal organic frameworks materials, carbon nanomaterials and silica-based nanoparticles. Their applications include the areas of food sciences, environmental, pharmaceutical, biological and medical analysis. Sample preparation throughput, purification performance, or sensitivity were improved by the utilization of the nanomaterials at some extent. However, the current forms of most nanomaterials are not available at an affordable cost, and the implementation of nanomaterials in sample preparation is far from efficient in routine analysis. Thus we aim to explore easy and economical synthetic methods of nanomaterial-based sorbents, the innovation on their surface chemistry modification for selective extraction, and how to make use of the superior properties of nanomaterials and expand their application to more demanding analytical tasks.

Subjects covered in this Research Topic include, but are not limited to, the following:

• Synthesis and design of new nanomaterials.
• Modification of nanomaterials with novel functional moieties.
• Integration of nanomaterials with new extraction modes.
• Investigation of extraction mechanism of new nanomaterials.
• Application of nanomaterials for challenging samples analysis, such as single cell analysis, biomarker exploration, metabolomics, and proteomics.
• Coupling of nanomaterial with other analytical strategies, such as multidimensional analysis, chemical derivatization, etc.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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