Research Topic

Bioactive Compounds and Diabetes Mellitus: Prospects and Challenges

About this Research Topic

Diabetes mellitus is an endocrine disorder characterized by metabolic abnormalities. Hyperglycemia and hyperlipidemia are two of the main metabolic dysregulations in diabetes, and two important culprits in subsequent diabetic complications. Uncontrolled hyperglycemia and hyperlipidemia are linked with injuries in tissues and organs leading to diabetic complications such as nephropathy neuropathy, retinopathy, cardiomyopathy and atherosclerosis. Hyperglycemia and hyperlipidemia cause cellular damage through induction of oxidative stress and inflammation.

Bioactive compounds are generally food components capable of regulating or modulating metabolic pathways or processes and with a positive impact on health. Specifically, polyphenolic compounds, of which flavonoids are the most prominent, are recognized as of one of the most important bioactive compounds. The compounds are potent free radical scavengers and antioxidant defense system enhancers. They have been found to exert strong anti-inflammatory effects. Considering the role of oxidative stress and inflammation in the etiology of diabetic complications, the antioxidant and anti-inflammatory effects of bioactive compounds are vital and have been demonstrated to mitigate against diabetic complications. Evidence has also revealed that bioactive compounds can suppress or ameliorate hyperglycemia and hyperlipidemia as well as improve glycemic control and other metabolic dysregulations.

Bioactive compounds have great prospects in managing diabetes mellitus in view of their beneficial health effects, safety and limited adverse effects since they are generally of natural sources. However, there are still challenges that need to be addressed and further research needs to be conducted before the utilization of bioactive compounds in diabetes mellitus can gain a widespread acceptability. These include addressing conflicting data on the effectiveness of bioactive compounds in diabetes mellitus, choice of optimal dose(s), difficulties in translation of data obtained in rodents to human studies, lack of characterization and unclear mechanism(s) of action of bioactive compounds.

This Research Topic therefore welcomes original research and review articles that fall within the scope of this topic. We welcome manuscripts on but not limited to the following sub-themes:

1. Studies that evaluate the therapeutic effects of existing and/or new bioactive compounds with a focus on human studies with diabetes mellitus.

2. Studies that elucidate mechanisms by which bioactive compounds ameliorate metabolic abnormalities in diabetes mellitus with a particular emphasis or focus on a translational aspect with human relevance.

3. Studies that address drawbacks in research involving bioactive compounds in diabetes mellitus including adverse effects and interactions.

4. Studies that may be related to the above 1-3 that are conducted in pre-diabetes condition which can help address disease prevention issues.

5. Computer simulation models related to pre-diabetes and diabetic conditions.


Keywords: Bioactive Compounds, Hyperglycemia, Diabetes Mellitus, Flavonoids, Oxidative Stress, Diabetic Complications


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Diabetes mellitus is an endocrine disorder characterized by metabolic abnormalities. Hyperglycemia and hyperlipidemia are two of the main metabolic dysregulations in diabetes, and two important culprits in subsequent diabetic complications. Uncontrolled hyperglycemia and hyperlipidemia are linked with injuries in tissues and organs leading to diabetic complications such as nephropathy neuropathy, retinopathy, cardiomyopathy and atherosclerosis. Hyperglycemia and hyperlipidemia cause cellular damage through induction of oxidative stress and inflammation.

Bioactive compounds are generally food components capable of regulating or modulating metabolic pathways or processes and with a positive impact on health. Specifically, polyphenolic compounds, of which flavonoids are the most prominent, are recognized as of one of the most important bioactive compounds. The compounds are potent free radical scavengers and antioxidant defense system enhancers. They have been found to exert strong anti-inflammatory effects. Considering the role of oxidative stress and inflammation in the etiology of diabetic complications, the antioxidant and anti-inflammatory effects of bioactive compounds are vital and have been demonstrated to mitigate against diabetic complications. Evidence has also revealed that bioactive compounds can suppress or ameliorate hyperglycemia and hyperlipidemia as well as improve glycemic control and other metabolic dysregulations.

Bioactive compounds have great prospects in managing diabetes mellitus in view of their beneficial health effects, safety and limited adverse effects since they are generally of natural sources. However, there are still challenges that need to be addressed and further research needs to be conducted before the utilization of bioactive compounds in diabetes mellitus can gain a widespread acceptability. These include addressing conflicting data on the effectiveness of bioactive compounds in diabetes mellitus, choice of optimal dose(s), difficulties in translation of data obtained in rodents to human studies, lack of characterization and unclear mechanism(s) of action of bioactive compounds.

This Research Topic therefore welcomes original research and review articles that fall within the scope of this topic. We welcome manuscripts on but not limited to the following sub-themes:

1. Studies that evaluate the therapeutic effects of existing and/or new bioactive compounds with a focus on human studies with diabetes mellitus.

2. Studies that elucidate mechanisms by which bioactive compounds ameliorate metabolic abnormalities in diabetes mellitus with a particular emphasis or focus on a translational aspect with human relevance.

3. Studies that address drawbacks in research involving bioactive compounds in diabetes mellitus including adverse effects and interactions.

4. Studies that may be related to the above 1-3 that are conducted in pre-diabetes condition which can help address disease prevention issues.

5. Computer simulation models related to pre-diabetes and diabetic conditions.


Keywords: Bioactive Compounds, Hyperglycemia, Diabetes Mellitus, Flavonoids, Oxidative Stress, Diabetic Complications


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 March 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 March 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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