Research Topic

Protein Folding, Misfolding, and Disease: a Tribute to Sir Chris Dobson

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Chris pioneered the research on protein misfolding, especially the amyloid state that is the hallmark of several diseases, including neurological disorders such as Alzheimer’s disease. During his remarkable career he provided a fundamental understanding on the nature, mechanisms of formation and toxicity of ...

Chris pioneered the research on protein misfolding, especially the amyloid state that is the hallmark of several diseases, including neurological disorders such as Alzheimer’s disease. During his remarkable career he provided a fundamental understanding on the nature, mechanisms of formation and toxicity of amyloids.

Chris trained and inspired generations of scientists and we would like to pay him tribute by hosting a collection of articles about topics that represent his outstanding scientific career. Articles in this collection will cover different subjects regarding folding, misfolding, and aggregation mechanisms of proteins. These works will focus, in particular, on the biophysics and structural determination of protein aggregation.

In this Research Topic, we welcome the submission of Scientific Papers, Review, Mini-Review, Opinion, and Perspective articles on:

- Structural protein determination
- Mechanisms of protein aggregation
- Predictions of the amyloid state
- Solubility as a constrain the evolution of protein molecules
- Molecular factors affecting amyloid formation and toxicity
- Experimental models of amyloid diseases
- Cellular response to protein misfolding and amyloid aggregation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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