Research Topic

Advances in the Biofabrication of 3D Tissue Models

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In vitro 3D tissue models began in the middle of the 20th century with the use of explant tissue cultures. Today, 3D tissue models range from 3D printed stem cell-laden hydrogels and organoids to whole organ models. The biofabrication techniques utilized to produce these different models vary widely ...

In vitro 3D tissue models began in the middle of the 20th century with the use of explant tissue cultures. Today, 3D tissue models range from 3D printed stem cell-laden hydrogels and organoids to whole organ models. The biofabrication techniques utilized to produce these different models vary widely and are continuously advancing. Although biofabrication techniques are evolving rapidly, there is a demand for the further integration of current techniques, development of novel techniques, and new uses for unconventional techniques.

Techniques that dominate this field are electrospinning (eg. traditional and melt-electro writing) and bioprinting (eg. extrusion-based and laser-based). Advancements in electrospinning include the most recent melt-electrospin writing whereby fiber deposition is controlled as if writing with a pen, whereas bioprinting methods are capable of not only integrating cells directly in the printing process, but capable of specifically placing cells in certain areas of the tissue. Moreover, the equipment to combine these techniques is already available for the fabrication of complex structures. The development of bioprinting methods are rapidly progressing, the most recent of which push the boundaries when it comes to the types of structures (eg. the overall dimensions and tissue thickness) that can be fabricated.

In this Research Topic, we aim to highlight innovative biofabrication techniques for the production of complex 3D tissue models that more closely resemble the physiological organ-like structure and function. We encourage submissions addressing:

(1) Integration of novel and classical biofabrication techniques
(2) Development of novel biofabrication techniques
(3) Production of healthy or pathological 3D tissue models
(4) Defining biofabrication techniques in reproducible 3D tissue models
(5) Miniature 3D tissue model biofabrication for high-throughput screening


Keywords: Biofabrication, Tissue Engineering, 3D Tissue Model, In Vitro


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