Research Topic

Liquid Biopsy: a Tool for Better Understanding of the Metastatic Process Ecosystem

About this Research Topic

Liquid biopsy, a non-invasive diagnostic technique, allows access to biomarkers found in bodily fluids, primarily blood-borne biomarkers. This sampling technique has received great attention in the field of oncology, where the term more precisely refers to the sampling of circulating tumor cells (CTCs), ...

Liquid biopsy, a non-invasive diagnostic technique, allows access to biomarkers found in bodily fluids, primarily blood-borne biomarkers. This sampling technique has received great attention in the field of oncology, where the term more precisely refers to the sampling of circulating tumor cells (CTCs), circulating-free tumor nucleic acids (ctNAs), and tumor-secreted extracellular vesicles (tEVs), all of which can be found in the blood of cancer patients. These biomarkers have been mainly studied due to their clinically informative value for diagnostic, prognostic, and monitoring of response to therapy. However, CTCs, ctNAs, and tEVs also play an active role in the metastatic process, suggesting that liquid biopsies might also provide new opportunities to explore the biological and molecular mechanisms of tumor dissemination.

CTCs that shed from the primary tumor site are able to extravasate and, within a favorable microenvironment, proliferate to form a new metastatic lesion. CTCs can be associated with blood cells (e.g. platelets, lymphocytes), and part of that interaction is seemingly mediated by specific proteins expressed by both cell types. ctNAs can be actively taken up by cells and ultimately associate with cell chromosomes, suggesting that they may act as mobile genetic elements. Furthermore, tEVs are critical mediators of intercellular communication between tumor and stromal cells in local as well as distant microenvironments. Taken together, this multifaceted communication between CTCs and the surrounding blood microenvironment, which seems to involve ctNAs and tEVs, appears to have a significant role in shaping tumor progression.

This Research Topic aims to highlight the different aspects of the biology of cancer metastasis that can be addressed with the application of liquid biopsies. We welcome Original Research and Review articles focused on, but not limited to, the nature of the interactions between CTCs, and other cell types during circulation in the bloodstream in which ctNAs and tEV play a key role. Potential sub-topics include:

1) Application of sensitive technologies for liquid biopsy.
2) Liquid biopsy and 3D culture, including organoid-based studies.
3) Circulating Tumour Cell-Derived Pre-Clinical Models.
4) CTCs, CNA and EVs molecular characterization.
5) CTCs, CNA and EVs interaction with both blood and tumor microenvironments.
6) CTCs, CNA and EVs impact in the metastatic process.


Keywords: liquid biopsy, metastasis, CTCs, cfDNA, cfmRNA, cfmiRNA, EVs, blood microenvironment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

25 May 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

25 May 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..