Research Topic

The Role of Polyploid Giant Cancer Cells in Tumor Heterogeneity and Chemoradiotherapy Resistance

About this Research Topic

The number of PGCCs in tumor tissue is closely related to the pathological grade, tumor differentiation, clinical stage, distant metastasis and chemoradiotherapy resistance, and patient prognosis. Furthermore, PGCCs are more abundant in tumors with metastasis than those in tumors without metastasis. In the ...

The number of PGCCs in tumor tissue is closely related to the pathological grade, tumor differentiation, clinical stage, distant metastasis and chemoradiotherapy resistance, and patient prognosis. Furthermore, PGCCs are more abundant in tumors with metastasis than those in tumors without metastasis. In the same patient, the number of PGCCs in recurrent tumors after radiotherapy and/or chemotherapy is higher than that in the primary tumor without radiotherapy or chemotherapy. Tumor tissues with greater abundance of PGCCs show more pronounced resistance to chemo- and radiotherapy than those with fewer PGCCs.

This Research Topic will cover the area of the molecular biology of PGCCs and cancer stem cells where modern methodologies, recent findings, and critical reviews shed light on the multiple roles of PGCCs in cancer and provide a platform to understand the relationship between PGCCs and chemoradiotherapy resistance.

Submissions of Original Research and Review articles from the researchers involved in the above-mentioned areas of PGCCs studies are particularly encouraged.

Potential topics include, but are not limited to:
1. Role of PGCCs in the heterogeneity of tumors.
2. Molecular mechanisms associated with the formation of PGCCs induced by chemotherapeutic drugs and radiotherapy.
3. The relationship between PGCCs and cancer stem cells.
4. Cancer treatment for inhibiting the formation of PGCCs.


Keywords: Chemoradiotherapy resistance, Polyploid giant cancer cells, Cancer stem cells, Epithelial mesenchymal transition


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 June 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 June 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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